PMID- 28941745
OWN - NLM
STAT- MEDLINE
DCOM- 20180706
LR  - 20231213
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 78
IP  - 11-12
DP  - 2017 Nov
TI  - Overexpression of immunomodulatory mediators in oral precancerous lesions.
PG  - 752-757
LID - S0198-8859(17)30494-9 [pii]
LID - 10.1016/j.humimm.2017.09.003 [doi]
AB  - Human leukocyte antigen (HLA) G and E, programmed cell death 1 ligand 1 (PD-L1), 
      IL-10 and TGF-beta are proteins involved in failure of the antitumor immune 
      response. We investigated the expression of these immunomodulatory mediators in 
      oral precancerous lesions (oral leukoplakia-OL; n=80) and whether these molecules 
      were related to the risk of malignant transformation. Samples of normal mucosa 
      (n=20) and oral squamous cells carcinoma (OSCC, n=20) were included as controls. 
      Tissue and saliva samples were analyzed by immunohistochemistry and ELISA 
      respectively. Fifteen OL samples showed severe dysplasia (18.7%) and 40 samples 
      (50%) presented combined high Ki-67/p53. Irrespective of the degree of epithelial 
      dysplasia and the proliferation/apoptosis index of OL, the expression of HLA-G, 
      -E, PD-L1, IL-10, TGF-beta2 and -beta3 was higher to control (P<0.05) and similar to 
      OSCC (P>0.05). The number of granzyme B(+) cells in OL was similar to control 
      (P=0.28) and lower compared to OSCC (P<0.01). Salivary concentrations of sHLA-G, 
      IL-10 and TGF-beta did not allow for a distinction between OL and healthy 
      individuals. Overexpression of immunosuppressive mediators in the OL reflects the 
      immune evasion potential of this lesion, which is apparently independent of at 
      cytological and proliferation/apoptosis status.
CI  - Copyright (c) 2017 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Goncalves, Andreia Souza
AU  - Goncalves AS
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: andreia.sg.odonto@gmail.com.
FAU - Mosconi, Carla
AU  - Mosconi C
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: carlamosconi@gmail.com.
FAU - Jaeger, Filipe
AU  - Jaeger F
AD  - Department of Oral Surgery and Pathology, Dental School, Federal University of 
      Minas Gerais, Belo Horizonte, Brazil. Electronic address: filipejaeger@gmail.com.
FAU - Wastowski, Isabela Jube
AU  - Wastowski IJ
AD  - Department of Biology, State University of Goias, Morrinhos, Goias, Brazil. 
      Electronic address: wastowski@gmail.com.
FAU - Aguiar, Maria Cassia Ferreira
AU  - Aguiar MCF
AD  - Department of Oral Surgery and Pathology, Dental School, Federal University of 
      Minas Gerais, Belo Horizonte, Brazil. Electronic address: cassiafaster@gmail.com.
FAU - Silva, Tarcilia Aparecida
AU  - Silva TA
AD  - Department of Oral Surgery and Pathology, Dental School, Federal University of 
      Minas Gerais, Belo Horizonte, Brazil. Electronic address: 
      tarcilia@odonto.ufmg.br.
FAU - Ribeiro-Rotta, Rejane Faria
AU  - Ribeiro-Rotta RF
AD  - Department of Stomatology (Oral Medicine), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: rejanefrr@gmail.com.
FAU - Costa, Nadia Lago
AU  - Costa NL
AD  - Department of Stomatology (Oral Medicine), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: nadialago@hotmail.com.
FAU - Batista, Aline Carvalho
AU  - Batista AC
AD  - Department of Stomatology (Oral Pathology), Dental School, Federal University of 
      Goias, Goiania, Brazil. Electronic address: ali.caba@uol.com.br.
LA  - eng
PT  - Journal Article
DEP - 20170921
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (B7-H1 Antigen)
RN  - 0 (HLA-G Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Immunologic Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adult
MH  - B7-H1 Antigen/genetics/metabolism
MH  - Carcinoma, Squamous Cell/*genetics
MH  - Cell Proliferation
MH  - Cell Transformation, Neoplastic
MH  - Epithelial Cells/*pathology
MH  - Female
MH  - Gene Expression Regulation, Neoplastic
MH  - HLA-G Antigens/genetics/metabolism
MH  - Histocompatibility Antigens Class I/genetics/metabolism
MH  - Humans
MH  - Immunologic Factors/genetics/metabolism
MH  - Interleukin-10/genetics/metabolism
MH  - Leukoplakia, Oral/*genetics
MH  - Male
MH  - Middle Aged
MH  - Mouth Mucosa/*physiology
MH  - Mouth Neoplasms/*genetics
MH  - Precancerous Conditions/*genetics
MH  - Transforming Growth Factor beta/genetics/metabolism
MH  - HLA-E Antigens
OTO - NOTNLM
OT  - HLA-G
OT  - Immune evasion
OT  - Oral cancer
OT  - Oral leucoplakia
OT  - Programmed cell death 1 ligand 1
EDAT- 2017/09/25 06:00
MHDA- 2018/07/07 06:00
CRDT- 2017/09/25 06:00
PHST- 2017/04/30 00:00 [received]
PHST- 2017/09/05 00:00 [revised]
PHST- 2017/09/19 00:00 [accepted]
PHST- 2017/09/25 06:00 [pubmed]
PHST- 2018/07/07 06:00 [medline]
PHST- 2017/09/25 06:00 [entrez]
AID - S0198-8859(17)30494-9 [pii]
AID - 10.1016/j.humimm.2017.09.003 [doi]
PST - ppublish
SO  - Hum Immunol. 2017 Nov;78(11-12):752-757. doi: 10.1016/j.humimm.2017.09.003. Epub 
      2017 Sep 21.