PMID- 28942954 OWN - NLM STAT- MEDLINE DCOM- 20181126 LR - 20181126 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 262 DP - 2018 Apr TI - Serum brain-derived neurotrophic factor levels in subjects with major depressive disorder with previous suicide attempt: A population-based study. PG - 500-504 LID - S0165-1781(17)30503-6 [pii] LID - 10.1016/j.psychres.2017.09.033 [doi] AB - Major depressive disorders (MDD) and suicide are significant public health concerns. Recent studies have been demonstrated that alterations in Brain Derived Neurotrophic Factor (BDNF) can be associated with this psychiatric disorders, MDD and suicide. Thus, the aim of this study was to evaluate differences in serum levels in individuals with MDD and with or without suicide attempt (SA), from a population-based sample. This was a paired cross-sectional study nested in a population-based study. The psychopathology screen was performed with the Mini-International Neuropsychiatric Interview (MINI). The total population of the sample consisted of 147 subjects distributed in three groups: 49 healthy controls, 49 subjects with MDD and 49 subjects with MDD and SA (MDD + SA). The BDNF serum levels were significantly reduced in subjects with MDD and MDD + SA compared to the healthy controls. However, there were no significant differences between the MDD and MDD + SA groups with respect to BDNF serum levels. These results suggest that SA did not interfere in the serum levels of BDNF, indicating that this neurotrophin may be related to the diagnosis of MDD and not to suicide attempt. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Pedrotti Moreira, Fernanda AU - Pedrotti Moreira F AD - Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - Borges, Cristiane Jackson AU - Borges CJ AD - Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - Wiener, Carolina David AU - Wiener CD AD - Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Postgraduate Program in Epidemiology, Federal University of Pelotas, RS, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - da Silva, Paula Moraes AU - da Silva PM AD - Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - Portela, Luis Valmor AU - Portela LV AD - Neurotrauma Laboratory, Department of Biochemistry, Institute of Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - Lara, Diogo R AU - Lara DR AD - Neurochemistry and Psychopharmacology Laboratory, Cellular and Molecular Biology Department, Faculty of Bioscience, Pontifical Catholic University of Rio Grande do Sul (PUC-RS), Porto Alegre, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - da Silva, Ricardo Azevedo AU - da Silva RA AD - Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - de Mattos Souza, Luciano Dias AU - de Mattos Souza LD AD - Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - Jansen, Karen AU - Jansen K AD - Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil. FAU - Oses, Jean Pierre AU - Oses JP AD - Translational Science on Brain Disorders, Clinical Neuroscience Laboratory, Department of Health and Behavior, Catholic University of Pelotas, RS, Brazil; Laboratory of Molecular Psychiatry, Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil; Technology Application in Neurosciences, Department of Electronic Engineering and Computer, Catholic University of Pelotas, Brazil. Electronic address: jean.pierre.oses@gmail.com. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20170914 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Adult MH - Brain-Derived Neurotrophic Factor/*blood MH - Cross-Sectional Studies MH - Depressive Disorder, Major/*blood MH - Female MH - Humans MH - Male MH - *Suicide, Attempted MH - Young Adult OTO - NOTNLM OT - BDNF OT - Biomarker OT - Depression OT - Suicide attempt EDAT- 2017/09/26 06:00 MHDA- 2018/11/27 06:00 CRDT- 2017/09/26 06:00 PHST- 2017/03/21 00:00 [received] PHST- 2017/08/30 00:00 [revised] PHST- 2017/09/11 00:00 [accepted] PHST- 2017/09/26 06:00 [pubmed] PHST- 2018/11/27 06:00 [medline] PHST- 2017/09/26 06:00 [entrez] AID - S0165-1781(17)30503-6 [pii] AID - 10.1016/j.psychres.2017.09.033 [doi] PST - ppublish SO - Psychiatry Res. 2018 Apr;262:500-504. doi: 10.1016/j.psychres.2017.09.033. Epub 2017 Sep 14.