PMID- 2894314
OWN - NLM
STAT- MEDLINE
DCOM- 19880418
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 144
IP  - 3
DP  - 1987 Dec 15
TI  - Excessive grooming induced by somatostatin or its analog SMS 201-995.
PG  - 277-85
AB  - Intracerebroventricular (i.c.v.) administration of somatostatin or SMS 201-995 
      induces excessive grooming behavior in rats. The grooming inducing effect of 
      somatostatin is rather weak, as doses of 300 ng or less did not result in 
      increased total grooming scores. In contrast a dose of 10 ng SMS 201-995 already 
      significantly increased the total grooming scores. However, doses of 100 ng and 
      more did not further increase the total grooming scores reached with a 50 ng dose 
      of this peptide. Systemic administration of SMS 201-995 in doses up to 900 
      micrograms did not result in excessive grooming behavior. The patterns of 
      excessive grooming induced by i.c.v. SMS 201-995 and somatostatin were 
      characterized by a predominant display of scratching. Since peptide-induced 
      scratching is mainly due to activation of opiate receptor systems it is suggested 
      that opiate receptors are involved in the behavioral response to SMS 201-995 and 
      somatostatin administration. This suggestion is further supported by the 
      suppressive effect of naloxone on excessive grooming induced by these peptides. 
      Haloperidol and neurotensin also suppress the excessive grooming induced by 
      somatostatin but not that induced by SMS 201-995. Finally, tolerance developed to 
      the grooming-inducing effect of SMS 201-995 and somatostatin. In addition there 
      was cross tolerance between somatostatin and SMS 201-995.
FAU - Van Wimersma Greidanus, T B
AU  - Van Wimersma Greidanus TB
AD  - Rudolf Magnus Institute for Pharmacology, Medical Faculty, University of Utrecht, 
      The Netherlands.
FAU - Maigret, C
AU  - Maigret C
FAU - Krechting, B
AU  - Krechting B
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Receptors, Opioid)
RN  - 36B82AMQ7N (Naloxone)
RN  - 39379-15-2 (Neurotensin)
RN  - 51110-01-1 (Somatostatin)
RN  - J6292F8L3D (Haloperidol)
RN  - RWM8CCW8GP (Octreotide)
SB  - IM
MH  - Animals
MH  - Dose-Response Relationship, Drug
MH  - Drug Tolerance
MH  - Grooming/*drug effects/physiology
MH  - Haloperidol/pharmacology
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/pharmacology
MH  - Neurotensin/pharmacology
MH  - Octreotide
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Receptors, Opioid/drug effects/physiology
MH  - Somatostatin/administration & dosage/*analogs & derivatives/*pharmacology
EDAT- 1987/12/15 00:00
MHDA- 1987/12/15 00:01
CRDT- 1987/12/15 00:00
PHST- 1987/12/15 00:00 [pubmed]
PHST- 1987/12/15 00:01 [medline]
PHST- 1987/12/15 00:00 [entrez]
AID - 0014-2999(87)90380-3 [pii]
AID - 10.1016/0014-2999(87)90380-3 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1987 Dec 15;144(3):277-85. doi: 10.1016/0014-2999(87)90380-3.