PMID- 28943602
OWN - NLM
STAT- MEDLINE
DCOM- 20180725
LR  - 20180725
IS  - 1347-3700 (Electronic)
IS  - 0386-7196 (Linking)
VI  - 42
IP  - 2
DP  - 2017 Oct 28
TI  - Deltamethrin Increases Neurite Outgrowth in Cortical Neurons through Endogenous 
      BDNF/TrkB Pathways.
PG  - 141-148
LID - 10.1247/csf.17015 [doi]
AB  - Deltamethrin (DM), a type II pyrethroid, robustly increases brain-derived 
      neurotrophic factor (Bdnf) expression and has a neurotrophic effect in primary 
      cultures of rat cortical neurons. In this study, we investigated the effect of DM 
      on neurite morphology in cultured rat cortical neurons. DM significantly 
      increased neurite outgrowth, but this increase was abolished when the BDNF 
      scavenger tropomyosin receptor kinase B (TrkB)-Fc was added 10 min before the DM 
      treatment. In contrast, the addition of TrkB-Fc 1 h after the treatment did not 
      affect DM-induced neurite outgrowth. Our previous research has indicated that 
      type II, but not type I, pyrethroids have the ability to induce Bdnf mRNA 
      expression, but neither permethrin nor cypermethrin, which are type I and type II 
      pyrethroids, respectively, affected neurite outgrowth in the current study. These 
      results suggest that this effect is not due to increased Bdnf expression, and the 
      effect is unique to DM. We previously demonstrated that calcineurin plays a role 
      in the DM-mediated induction of Bdnf expression. However, the calcineurin 
      inhibitor FK506 did not significantly affect DM-induced neurite outgrowth. 
      DM-induced neurite outgrowth was abolished by U0126 and rapamycin, indicating the 
      involvement of the mitogen-activated protein kinase (MAPK) and mammalian target 
      of rapamycin (mTOR) pathways. Taken together, these findings suggest that DM 
      activates endogenous BDNF/TrkB-mediated MAPK and mTOR pathways, thereby 
      increasing neurite outgrowth.Key words: BDNF, Deltamethrin, MAPK, mTOR, Neurite 
      outgrowth.
FAU - Ihara, Daisuke
AU  - Ihara D
AD  - Department of Biological Chemistry, Graduate School of Medicine and 
      Pharmaceutical Sciences, University of Toyama.
FAU - Fukuchi, Mamoru
AU  - Fukuchi M
AD  - Department of Biological Chemistry, Graduate School of Medicine and 
      Pharmaceutical Sciences, University of Toyama.
AD  - Laboratory of Molecular Neuroscience, Faculty of Pharmacy, Takasaki University of 
      Health and Welfare.
FAU - Katakai, Momoko
AU  - Katakai M
AD  - Laboratory of Molecular Neuroscience, Department of Applied Biological Science, 
      Faculty of Science and Technology, Tokyo University of Science.
FAU - Shinoda, Yo
AU  - Shinoda Y
AD  - Laboratory of Molecular Neuroscience, Department of Applied Biological Science, 
      Faculty of Science and Technology, Tokyo University of Science.
AD  - Department of Environmental Health, School of Pharmacy, Tokyo University of 
      Pharmacy and Life Sciences.
FAU - Katoh-Semba, Ritsuko
AU  - Katoh-Semba R
AD  - Laboratory of Molecular Neuroscience, Department of Applied Biological Science, 
      Faculty of Science and Technology, Tokyo University of Science.
FAU - Furuichi, Teiichi
AU  - Furuichi T
AD  - Laboratory of Molecular Neuroscience, Department of Applied Biological Science, 
      Faculty of Science and Technology, Tokyo University of Science.
FAU - Ishikawa, Mitsuru
AU  - Ishikawa M
AD  - Department of Biological Chemistry, Graduate School of Medicine and 
      Pharmaceutical Sciences, University of Toyama.
AD  - Department of Physiology, Keio University School of Medicine.
FAU - Tabuchi, Akiko
AU  - Tabuchi A
AD  - Department of Biological Chemistry, Graduate School of Medicine and 
      Pharmaceutical Sciences, University of Toyama.
FAU - Tsuda, Masaaki
AU  - Tsuda M
AD  - Department of Biological Chemistry, Graduate School of Medicine and 
      Pharmaceutical Sciences, University of Toyama.
LA  - eng
PT  - Journal Article
DEP - 20170923
PL  - Japan
TA  - Cell Struct Funct
JT  - Cell structure and function
JID - 7608465
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insecticides)
RN  - 0 (Nitriles)
RN  - 0 (Pyrethrins)
RN  - 2JTS8R821G (decamethrin)
RN  - EC 2.7.10.1 (Receptor, trkB)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cells, Cultured
MH  - Cerebral Cortex/*cytology
MH  - Insecticides/*pharmacology
MH  - Neuronal Outgrowth/*drug effects
MH  - Neurons/cytology/*drug effects/metabolism
MH  - Nitriles/*pharmacology
MH  - Pyrethrins/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/*metabolism
OTO - NOTNLM
OT  - BDNF
OT  - Deltamethrin
OT  - MAPK
OT  - Neurite outgrowth
OT  - mTOR
EDAT- 2017/09/26 06:00
MHDA- 2018/07/26 06:00
CRDT- 2017/09/26 06:00
PHST- 2017/09/26 06:00 [pubmed]
PHST- 2018/07/26 06:00 [medline]
PHST- 2017/09/26 06:00 [entrez]
AID - 10.1247/csf.17015 [doi]
PST - ppublish
SO  - Cell Struct Funct. 2017 Oct 28;42(2):141-148. doi: 10.1247/csf.17015. Epub 2017 
      Sep 23.