PMID- 28944174
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2225-319X (Print)
IS  - 2304-1021 (Electronic)
IS  - 2225-319X (Linking)
VI  - 6
IP  - 4
DP  - 2017 Jul
TI  - Hypertrophic obstructive cardiomyopathy-the Leipzig experience.
PG  - 337-342
LID - 10.21037/acs.2017.07.09 [doi]
AB  - BACKGROUND: Management of hypertrophic obstructive cardiomyopathy (HOCM) has 
      evolved considerably over the last fifty years, and includes medical treatment as 
      well as septal myectomy (SM) to relief symptoms caused by left ventricular 
      outflow tract obstruction (LVOTO). We report the Leipzig Heart Center experience 
      in the surgical management of patients with HOCM. METHODS: We collected data from 
      all patient treated surgically with a myectomy for LVOTO in patients with HOCM 
      between 1997 and 2016. Patients with absent data were excluded from our analysis. 
      All data were obtained from our surgical database and analyzed retrospectively. 
      RESULTS: We identified 115 patients who underwent surgical treatment for HOCM, 
      where a male:female ratio of 1.1:1, a mean age of 60.8+/-14.6 years and a body mass 
      index of 27.7+/-4.5 were observed. The most common symptom was dyspnea (n=102). Of 
      all patients, 50% had New York Heart Association (NYHA) III class symptoms. 
      Arterial hypertension was the most common comorbidity (n=80). Preoperative 
      transthoracic echocardiography showed a mean ejection fraction (EF) of 
      65.9%+/-9.7%, median septal thickness of 21.1+/-5.3 mm, systolic anterior motion of 
      the mitral valve (MV) in 61.7% of patients, and mean LVOT gradient of 70.1+/-45.2 
      mmHg. Surgery resulted in a mean decrease of the septal thickness by 15+/-3.7 mm 
      and LVOT gradient by 9.7+/-8.5 mmHg. Isolated SM was carried out on 20 patients. 
      Postoperatively, we were able to notice a significant improvement in NYHA 
      classification, in which patients with NYHA III benefitted most from SM. 
      Long-term follow-up data up to 11.3+/-0.7 years were available for 114 patients. 
      During follow-up, 16 patients died, and one patient was lost to follow up. 
      CONCLUSIONS: Surgical treatment of LVOT in patients with HOCM is an effective 
      intervention that improves cardiac function and quality of life (QoL) and is 
      associated with a low operative risk.
FAU - Khalil, Jawad
AU  - Khalil J
AD  - Department of Cardiac Surgery, Heart Centre, University of Leipzig, Leipzig, 
      Germany.
FAU - Kuehl, Michael
AU  - Kuehl M
AD  - Department of Electrophysiology, Heart Centre, University of Leipzig, Leipzig, 
      Germany.
FAU - Davierwala, Pirose
AU  - Davierwala P
AD  - Department of Cardiac Surgery, Heart Centre, University of Leipzig, Leipzig, 
      Germany.
FAU - Mohr, Friedrich Wilhelm
AU  - Mohr FW
AD  - Department of Cardiac Surgery, Heart Centre, University of Leipzig, Leipzig, 
      Germany.
FAU - Misfeld, Martin
AU  - Misfeld M
AD  - Department of Cardiac Surgery, Heart Centre, University of Leipzig, Leipzig, 
      Germany.
LA  - eng
PT  - Journal Article
PL  - China
TA  - Ann Cardiothorac Surg
JT  - Annals of cardiothoracic surgery
JID - 101605877
PMC - PMC5602203
OTO - NOTNLM
OT  - Hypertrophic obstructive cardiomyopathy (HOCM)
OT  - concomitant procedures
OT  - left ventricular outflow tract
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2017/09/26 06:00
MHDA- 2017/09/26 06:01
PMCR- 2017/07/01
CRDT- 2017/09/26 06:00
PHST- 2017/09/26 06:00 [entrez]
PHST- 2017/09/26 06:00 [pubmed]
PHST- 2017/09/26 06:01 [medline]
PHST- 2017/07/01 00:00 [pmc-release]
AID - acs-06-04-337 [pii]
AID - 10.21037/acs.2017.07.09 [doi]
PST - ppublish
SO  - Ann Cardiothorac Surg. 2017 Jul;6(4):337-342. doi: 10.21037/acs.2017.07.09.