PMID- 28944860
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20181113
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 16
IP  - 5
DP  - 2017 Nov
TI  - Polyaniline promotes peripheral nerve regeneration by enhancement of the 
      brain‑derived neurotrophic factor and ciliary neurotrophic factor expression and 
      activation of the ERK1/2/MAPK signaling pathway.
PG  - 7534-7540
LID - 10.3892/mmr.2017.7534 [doi]
AB  - A previous study has demonstrated a progression in the nerve regeneration by 
      polyaniline/cellulose (PANI/RC), although the underlying mechanism was not 
      elucidated. In the present study, regenerated nerves were investigated, using 
      histological techniques, functional assays and western blot analysis. The triceps 
      surae muscle weight ratio percentages of the sham, regenerated cellulose (RC) and 
      the PANI/RC groups were 38.88+/-4.76 and 76.32+/-7.11%, respectively. The thickness 
      of the myelin sheath for the aforementioned groups were as follows: 1.2+/-0.27; 
      0.49+/-0.21 and 0.93+/-0.28 microl. Western blot analysis demonstrated that the ciliary 
      neurotrophic factor (CNTF) and brain‑derived neurotrophic factor (BDNF) were 
      highly expressed in the regenerated nerve in the presence of polyaniline. 
      Phosphorylated extracellular kinase (p‑ERK)1/2 expression in the PANI/RC group 
      was significantly elevated compared with the RC group (1.83‑fold) and the sham 
      group (4.92‑fold). The expression of the axon sprout‑associated proteins, such as 
      Tau, alpha‑tubulin and growth associated protein‑43, were increased (1.64, 1.59 and 
      1.24‑fold, respectively) compared with the RC group. The results demonstrated 
      that PANI enhances the expression and secretion of BDNF and CNTF, activates the 
      ERK1/2 signaling pathway and increases the expression levels of the GAP‑43, Tau 
      and alpha‑tubulin, suggesting an insight into nerve regeneration and possible 
      clinical interventions in nerve injury.
FAU - Fan, Lin
AU  - Fan L
AD  - Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of 
      Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of 
      Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China.
FAU - Xiong, Yan
AU  - Xiong Y
AD  - Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of 
      Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of 
      Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China.
FAU - Fu, Zhen
AU  - Fu Z
AD  - Research Center of National Health Ministry on Transplantation Medicine 
      Engineering and Technology, The 3rd Xiangya Hospital of Central South University, 
      Changsha, Hunan 410013, P.R. China.
FAU - Xu, Dingfeng
AU  - Xu D
AD  - College of Chemistry & Molecule Sciences, Wuhan University, Wuhan, Hubei 430081, 
      P.R. China.
FAU - Wang, Lei
AU  - Wang L
AD  - Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of 
      Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of 
      Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China.
FAU - Chen, Yong
AU  - Chen Y
AD  - Department of Abdominal Laparoscopic Surgery, Qinghai University Affiliated 
      Hospital, Xining, Qinghai 810001, P.R. China.
FAU - Xia, Haoyang
AU  - Xia H
AD  - Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of 
      Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of 
      Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China.
FAU - Peng, Na
AU  - Peng N
AD  - Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of 
      Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of 
      Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China.
FAU - Ye, Shaojun
AU  - Ye S
AD  - Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of 
      Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of 
      Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China.
FAU - Wang, Yanfeng
AU  - Wang Y
AD  - Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of 
      Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of 
      Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China.
FAU - Zhang, Lina
AU  - Zhang L
AD  - College of Chemistry & Molecule Sciences, Wuhan University, Wuhan, Hubei 430081, 
      P.R. China.
FAU - Ye, Qifa
AU  - Ye Q
AD  - Zhongnan Hospital of Wuhan University, Institute of Hepatobiliary Diseases of 
      Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of 
      Medical Technology on Transplantation, Wuhan, Hubei 430071, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20170920
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (Aniline Compounds)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 0 (Cytokines)
RN  - 0 (GAP-43 Protein)
RN  - 0 (Tubulin)
RN  - 0 (polyaniline)
RN  - 0 (tau Proteins)
RN  - 9004-34-6 (Cellulose)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Aniline Compounds/*pharmacology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Cellulose/chemistry
MH  - Ciliary Neurotrophic Factor/*metabolism
MH  - Cytokines/metabolism
MH  - GAP-43 Protein/metabolism
MH  - MAP Kinase Signaling System/*drug effects
MH  - Male
MH  - Mitogen-Activated Protein Kinase 1/metabolism
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Nerve Regeneration/*drug effects
MH  - Peripheral Nerves/drug effects/pathology/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tubulin/metabolism
MH  - tau Proteins/metabolism
PMC - PMC5865887
EDAT- 2017/09/26 06:00
MHDA- 2018/06/07 06:00
PMCR- 2017/09/20
CRDT- 2017/09/26 06:00
PHST- 2017/01/13 00:00 [received]
PHST- 2017/08/02 00:00 [accepted]
PHST- 2017/09/26 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2017/09/26 06:00 [entrez]
PHST- 2017/09/20 00:00 [pmc-release]
AID - mmr-16-05-7534 [pii]
AID - 10.3892/mmr.2017.7534 [doi]
PST - ppublish
SO  - Mol Med Rep. 2017 Nov;16(5):7534-7540. doi: 10.3892/mmr.2017.7534. Epub 2017 Sep 
      20.