PMID- 2894610
OWN - NLM
STAT- MEDLINE
DCOM- 19880408
LR  - 20061115
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 332
IP  - 6159
DP  - 1988 Mar 3
TI  - Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in 
      insulinoma.
PG  - 85-7
AB  - Multiple endocrine neoplasia type 1 (MEN-1) is a predisposition to hyperplasia of 
      the parathyroid glands, and to hyperplasia or tumours of the anterior pituitary 
      and the endocrine pancreas, and is inherited as an autosomal dominant trait. Here 
      we map the MEN-1 locus to chromosome 11 by family studies, and demonstrate tight 
      linkage with the human muscle phosphorylase gene. By comparing constitutional and 
      tumour tissue genotypes of insulinomas from a pair of brothers who had inherited 
      MEN-1 from their mother, we have shown that oncogenesis in these cases involves 
      unmasking of a recessive mutation at this locus.
FAU - Larsson, C
AU  - Larsson C
AD  - Department of Clinical Genetics, Karolinska Hospital, Stockholm, Sweden.
FAU - Skogseid, B
AU  - Skogseid B
FAU - Oberg, K
AU  - Oberg K
FAU - Nakamura, Y
AU  - Nakamura Y
FAU - Nordenskjold, M
AU  - Nordenskjold M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (DNA, Recombinant)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Adenoma, Islet Cell/*genetics
MH  - Adult
MH  - Alleles
MH  - Cell Transformation, Neoplastic
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 11
MH  - DNA/genetics
MH  - DNA, Recombinant
MH  - Genotype
MH  - Humans
MH  - Hyperplasia
MH  - Insulinoma/*genetics
MH  - Islets of Langerhans/pathology
MH  - Male
MH  - Multiple Endocrine Neoplasia/*genetics
MH  - Pancreas/analysis/pathology
MH  - Pancreatic Neoplasms/*genetics
MH  - Parathyroid Glands/pathology
MH  - Pedigree
MH  - Pituitary Gland/pathology
MH  - Polymorphism, Restriction Fragment Length
MH  - Recombination, Genetic
EDAT- 1988/03/03 00:00
MHDA- 1988/03/03 00:01
CRDT- 1988/03/03 00:00
PHST- 1988/03/03 00:00 [pubmed]
PHST- 1988/03/03 00:01 [medline]
PHST- 1988/03/03 00:00 [entrez]
AID - 10.1038/332085a0 [doi]
PST - ppublish
SO  - Nature. 1988 Mar 3;332(6159):85-7. doi: 10.1038/332085a0.