PMID- 28946752
OWN - NLM
STAT- MEDLINE
DCOM- 20190717
LR  - 20240402
IS  - 1938-2731 (Electronic)
IS  - 1533-3175 (Print)
IS  - 1533-3175 (Linking)
VI  - 33
IP  - 1
DP  - 2018 Feb
TI  - Mental Training Enhances Cognitive Function and BDNF More Than Either Physical or 
      Combined Training in Elderly Women With MCI: A Small-Scale Study.
PG  - 20-29
LID - 10.1177/1533317517727068 [doi]
AB  - INTRODUCTION: The effects of mental, physical, and combination of these two 
      trainings were investigated on cognitive performance, serum level of brain 
      derived neurotrophic factor (BDNF), and irisin in women diagnosed with mild 
      cognitive impairment (MCI). MATERIAL AND METHODS: Forty-four participants were 
      randomized into 4 groups: physical training (PH; 8 weeks' aerobic training, n = 
      11), mental training (ME; special computer gaming, n = 11), combined (PH + ME; n 
      = 13), and control group (CO; n = 9). RESULTS: Analysis of variance with Tukey 
      post hoc test revealed a significant increase in working memory ( P = .012) and 
      BDNF ( P = 0.024) in the ME compared with the CO group. Also the ME group in 
      comparison with the PH group demonstrated better working memory ( P = .014) and 
      processing speed ( P = .024). CONCLUSION: Positive effect of mental training on 
      the cognitive parameters, parallel with BDNF elevation, suggests that mental 
      training is a more useful, safe, and persistent strategy to attenuate the 
      progression of MCI probably via BDNF elevation, but the effect size is relatively 
      small elevation.
FAU - Damirchi, Arsalan
AU  - Damirchi A
AD  - 1 Department of Exercise Physiology, Faculty of Physical Education and Sport 
      Sciences, University of Guilan, Rasht, Iran.
FAU - Hosseini, Fatemeh
AU  - Hosseini F
AD  - 1 Department of Exercise Physiology, Faculty of Physical Education and Sport 
      Sciences, University of Guilan, Rasht, Iran.
FAU - Babaei, Parvin
AU  - Babaei P
AD  - 2 Cellular & Molecular Research Center, Guilan University of Medical Science, 
      Rasht, Iran.
AD  - 3 Neuroscience Research Center, Guilan University of Medical Science, Rasht, 
      Iran.
LA  - eng
PT  - Journal Article
DEP - 20170925
PL  - United States
TA  - Am J Alzheimers Dis Other Demen
JT  - American journal of Alzheimer's disease and other dementias
JID - 101082834
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - *Brain-Derived Neurotrophic Factor/blood
MH  - Cognition/*physiology
MH  - Cognitive Dysfunction/*therapy
MH  - Exercise/*physiology
MH  - Female
MH  - Humans
MH  - Memory, Short-Term/physiology
MH  - Stroop Test/statistics & numerical data
PMC - PMC10852433
OTO - NOTNLM
OT  - Alzheimer
OT  - BDNF
OT  - MCI
OT  - cognitive performance
OT  - computer Stroop task
OT  - irisin
COIS- The authors declared no potential conflicts of interest with respect to the 
      research, authorship, and/or publication of this article.
EDAT- 2017/09/28 06:00
MHDA- 2019/07/18 06:00
PMCR- 2018/02/01
CRDT- 2017/09/27 06:00
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2019/07/18 06:00 [medline]
PHST- 2017/09/27 06:00 [entrez]
PHST- 2018/02/01 00:00 [pmc-release]
AID - 10.1177_1533317517727068 [pii]
AID - 10.1177/1533317517727068 [doi]
PST - ppublish
SO  - Am J Alzheimers Dis Other Demen. 2018 Feb;33(1):20-29. doi: 
      10.1177/1533317517727068. Epub 2017 Sep 25.