PMID- 28947280 OWN - NLM STAT- MEDLINE DCOM- 20180207 LR - 20181113 IS - 1872-7549 (Electronic) IS - 0166-4328 (Print) IS - 0166-4328 (Linking) VI - 338 DP - 2018 Feb 15 TI - Impaired cognitive flexibility during sleep deprivation among carriers of the Brain Derived Neurotrophic Factor (BDNF) Val66Met allele. PG - 51-55 LID - S0166-4328(17)30807-0 [pii] LID - 10.1016/j.bbr.2017.09.025 [doi] AB - Accumulating evidence points to a genetic contribution to explain inter-individual vulnerability to sleep deprivation. A functional polymorphism in the BDNF gene, which causes a valine (Val) to methionine (Met) amino acid substitution at Codon 66, has been associated with cognitive impairment, particularly in populations with impaired frontal functioning. We hypothesised that sleep deprivation, which affects frontal function, may lead to cognitive dysfunction in Met allele carriers. To examine this, we investigated, in different BDNF genotypes, the effects of sleep deprivation on cognitive flexibility, as measured by response inhibition using the Stroop Color Naming Task. Thirty healthy, adults of European ancestry, including 12 heterozygous Met allele carriers and 18 Val/Val homozygotes, underwent 30-h of extended wakefulness under constant routine conditions. A computerised Stroop task was administered every 2h. Error rate and reaction times increased with time awake for all individuals. Participants with the Val/Met genotype made more errors on incongruent trials after 20h awake. While Val/Met participants also took significantly longer to respond when inhibiting a prepotent response irrespective of time awake, this was particularly evident during the biological night. Our study shows that carriers of the BDNF Met allele are more vulnerable to the impact of prolonged wakefulness and the biological night on a critical component of executive function, as measured by response inhibition on the Stroop task. CI - Copyright (c) 2017 Elsevier B.V. All rights reserved. FAU - Grant, Leilah K AU - Grant LK AD - Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Clayton, Victoria 3800, Australia. FAU - Cain, Sean W AU - Cain SW AD - Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Clayton, Victoria 3800, Australia; Sleep Health Institute and Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA. FAU - Chang, Anne-Marie AU - Chang AM AD - Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Sleep Health Institute and Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA. FAU - Saxena, Richa AU - Saxena R AD - Department of Anesthesia, Critical Care and Pain Medicine and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. FAU - Czeisler, Charles A AU - Czeisler CA AD - Division of Sleep Medicine, Harvard Medical School, Boston, MA 02115, USA; Sleep Health Institute and Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA. FAU - Anderson, Clare AU - Anderson C AD - Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Monash University, Clayton, Victoria 3800, Australia; Sleep Health Institute and Division of Sleep and Circadian Disorders, Departments of Medicine and Neurology, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: clare.anderson@monash.edu. LA - eng GR - R01 DK107859/DK/NIDDK NIH HHS/United States GR - UL1 RR025758/RR/NCRR NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20170922 PL - Netherlands TA - Behav Brain Res JT - Behavioural brain research JID - 8004872 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adolescent MH - Adult MH - Alleles MH - Attention/physiology MH - Brain-Derived Neurotrophic Factor/*genetics MH - Cognition/*physiology MH - Executive Function/physiology MH - Female MH - Genotype MH - Humans MH - Male MH - Neuropsychological Tests MH - *Polymorphism, Single Nucleotide MH - Polysomnography MH - Reaction Time/*genetics MH - Sleep Deprivation/genetics/*psychology MH - Stroop Test MH - Young Adult PMC - PMC5957758 MID - NIHMS964568 OTO - NOTNLM OT - BDNF OT - Cognitive flexibility OT - Executive function OT - Sleep deprivation OT - Stroop OT - Val66Met COIS- Disclosure statement Drs. Cain, Chang and Saxena report no financial conflicts of interest in relation to this work. EDAT- 2017/09/28 06:00 MHDA- 2018/02/08 06:00 PMCR- 2018/05/17 CRDT- 2017/09/27 06:00 PHST- 2017/05/16 00:00 [received] PHST- 2017/08/21 00:00 [revised] PHST- 2017/09/13 00:00 [accepted] PHST- 2017/09/28 06:00 [pubmed] PHST- 2018/02/08 06:00 [medline] PHST- 2017/09/27 06:00 [entrez] PHST- 2018/05/17 00:00 [pmc-release] AID - S0166-4328(17)30807-0 [pii] AID - 10.1016/j.bbr.2017.09.025 [doi] PST - ppublish SO - Behav Brain Res. 2018 Feb 15;338:51-55. doi: 10.1016/j.bbr.2017.09.025. Epub 2017 Sep 22.