PMID- 28947924
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1931-7212 (Print)
IS  - 1931-7220 (Electronic)
IS  - 1931-7212 (Linking)
VI  - 12
IP  - 1
DP  - 2017 Mar
TI  - The Aging Overactive Bladder: A Review of Aging-Related Changes from the Brain to 
      the Bladder.
PG  - 42-47
LID - 10.1007/s11884-017-0406-7 [doi]
AB  - PURPOSE OF REVIEW: To understand the current literature on age-related neural and 
      detrusor changes associated with overactive bladder symptoms. RECENT FINDINGS: 
      Recent functional magnetic resonance imaging (fMRI) studies have unveiled an 
      age-related decrease in the neural control of continence, represented in the 
      insula, anterior cingulate cortex (ACC) and prefrontal cortex (PFC). Older 
      individuals with overactive bladder symptoms also demonstrate heightened 
      activation of the ACC with low volumes, representing increased bladder 
      sensitivity or sense of urgency. At the level of the bladder, age-related changes 
      in the urothelium, neurotransmitters/receptors (both muscarinic and purinergic), 
      and inflammation [including nerve growth factor (NGF), monocyte chemoattractant 
      protein-1 (MCP-1) and oxidative stress] are also associated with overactive 
      bladder. SUMMARY: Overactive bladder among older adults is a complex condition 
      incorporating physiologic age-related changes from the brain to the bladder and 
      beyond.
FAU - Suskind, Anne M
AU  - Suskind AM
AD  - Department of Urology, University of California, San Francisco, 400 Parnassus 
      Ave, Box 0738, San Francisco, CA 94143, USA.
LA  - eng
GR  - K12 DK083021/DK/NIDDK NIH HHS/United States
PT  - Journal Article
DEP - 20170206
PL  - United States
TA  - Curr Bladder Dysfunct Rep
JT  - Current bladder dysfunction reports
JID - 101299193
PMC - PMC5609730
MID - NIHMS849935
OTO - NOTNLM
OT  - Detrusor overactivity
OT  - geriatric
OT  - inflammation
OT  - neurotransmitters
OT  - white matter disease
COIS- Compliance with Ethics Guidelines Conflict of Interest Dr. Suskind has no 
      conflicts of interests to declare
EDAT- 2017/09/28 06:00
MHDA- 2017/09/28 06:01
PMCR- 2018/03/01
CRDT- 2017/09/27 06:00
PHST- 2017/09/27 06:00 [entrez]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2017/09/28 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - 10.1007/s11884-017-0406-7 [doi]
PST - ppublish
SO  - Curr Bladder Dysfunct Rep. 2017 Mar;12(1):42-47. doi: 10.1007/s11884-017-0406-7. 
      Epub 2017 Feb 6.