PMID- 28947990
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220317
IS  - 1949-2553 (Electronic)
IS  - 1949-2553 (Linking)
VI  - 8
IP  - 36
DP  - 2017 Sep 1
TI  - The prognostic value of preoperative neutrophils, platelets, lymphocytes, 
      monocytes and calculated ratios in patients with laryngeal squamous cell cancer.
PG  - 60514-60527
LID - 10.18632/oncotarget.16234 [doi]
AB  - This study was aimed to examine the prognostic value of preoperative neutrophils, 
      platelets, lymphocytes, monocytes and calculated ratios in patients with 
      laryngeal squamous cell cancer (LSCC). From January 2007 to December 2011, 979 
      patients with LSCC were enrolled in our study. Preoperative neutrophils, 
      platelets, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio (NLR), 
      platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were 
      analyzed. Besides well-established clinicopathological prognostic factors, we 
      evaluated the independent prognostic relevance of these hematological parameters 
      by Cox regression models in disease-free survival (DFS) and cancer-specific 
      survival (CSS). We found patients in the highest tertile of NLR (>2.40), PLR 
      (>111.00) were at significantly higher risk of DFS and CSS (P<0.05) compared with 
      those in the lowest tertile after multivariate analysis, whereas presenting 
      significantly higher risk in the lowest tertile of lymphocytes (<1.60x109/L) and 
      LMR (<3.50). Additionally, the tertile category of NLR as well as PLR increased 
      and lymphocytes as well as LMR decreased in shorter DFS and CSS by the 
      Kaplan-Meier method and the log-rank test. In conclusion, this study indicated 
      that preoperative lymphocytes, NLR, PLR and LMR were significantly associated 
      with LSCC progression, DFS and CSS, and these hematological parameters could be 
      considered independent prognostic values for patients with LSCC.
FAU - Hsueh, Chiyao
AU  - Hsueh C
AD  - Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, 
      Shanghai, PR China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China.
FAU - Tao, Lei
AU  - Tao L
AD  - Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, 
      Shanghai, PR China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China.
FAU - Zhang, Ming
AU  - Zhang M
AD  - Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, 
      Shanghai, PR China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China.
FAU - Cao, Wenjun
AU  - Cao W
AD  - Department of Clinical Laboratory, Eye & ENT Hospital, Shanghai Medical College, 
      Fudan University, PR China.
FAU - Gong, Hongli
AU  - Gong H
AD  - Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, 
      Shanghai, PR China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China.
FAU - Zhou, Jian
AU  - Zhou J
AD  - Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, 
      Shanghai, PR China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China.
FAU - Zhou, Liang
AU  - Zhou L
AD  - Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, 
      Shanghai, PR China.
AD  - Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China.
LA  - eng
PT  - Journal Article
DEP - 20170315
PL  - United States
TA  - Oncotarget
JT  - Oncotarget
JID - 101532965
PMC - PMC5601158
OTO - NOTNLM
OT  - laryngeal squamous carcinoma
OT  - lymphocyte-to-monocyte ratio
OT  - lymphocytes
OT  - neutrophil-to-lymphocyte ratio
OT  - prognosis
COIS- CONFLICTS OF INTEREST None declared.
EDAT- 2017/09/28 06:00
MHDA- 2017/09/28 06:01
PMCR- 2017/09/01
CRDT- 2017/09/27 06:00
PHST- 2016/12/27 00:00 [received]
PHST- 2017/02/20 00:00 [accepted]
PHST- 2017/09/27 06:00 [entrez]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2017/09/28 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 16234 [pii]
AID - 10.18632/oncotarget.16234 [doi]
PST - epublish
SO  - Oncotarget. 2017 Mar 15;8(36):60514-60527. doi: 10.18632/oncotarget.16234. 
      eCollection 2017 Sep 1.