PMID- 2894802
OWN - NLM
STAT- MEDLINE
DCOM- 19880411
LR  - 20220318
IS  - 0364-5134 (Print)
IS  - 0364-5134 (Linking)
VI  - 23 Suppl
DP  - 1988
TI  - Tropical spastic paraparesis in Colombia.
PG  - S127-32
AB  - A high-incidence focus of tropical spastic paraparesis (TSP) occurs on the South 
      Pacific coast of Colombia. Of 55 patients studied, 52 (94.5%) had IgG antibodies 
      to the human T-cell lymphotropic virus type I (HTLV-I) in serum and/or 
      cerebrospinal fluid. Control groups did not show similar high positivity. Our 
      results suggest that HTLV-I or other antigenically related retroviruses may be 
      the cause of TSP in Colombia. Similar clinical, laboratory, and epidemiological 
      findings have been reported in widely remote geographical regions of the world, 
      with very similar clinical pictures of TSP in all high-incidence regions. The 
      demonstration of IgG antibodies in serum and cerebrospinal fluid of patients with 
      TSP in the Caribbean and Seychelles Islands, southern Japan, and the Ivory Coast 
      indicate that the HTLV-I retrovirus could be the cause of this "tropical" 
      myeloneuropathy.
FAU - Zaninovic, V
AU  - Zaninovic V
AD  - Department of Internal Medicine, Faculty of Health, Universidad del Valle, Cali, 
      Colombia.
FAU - Arango, C
AU  - Arango C
FAU - Biojo, R
AU  - Biojo R
FAU - Mora, C
AU  - Mora C
FAU - Rodgers-Johnson, P
AU  - Rodgers-Johnson P
FAU - Concha, M
AU  - Concha M
FAU - Corral, R
AU  - Corral R
FAU - Barreto, P
AU  - Barreto P
FAU - Borrero, I
AU  - Borrero I
FAU - Garruto, R M
AU  - Garruto RM
AU  - et al.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Antibodies, Anti-Idiotypic)
RN  - 0 (Antibodies, Viral)
RN  - 0 (Deltaretrovirus Antibodies)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins)
RN  - 0 (Oligoclonal Bands)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Antibodies, Anti-Idiotypic/analysis/cerebrospinal fluid
MH  - Antibodies, Viral/*analysis/chemical synthesis
MH  - Colombia
MH  - Deltaretrovirus Antibodies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Immunoglobulin G/immunology
MH  - Immunoglobulins/analysis/cerebrospinal fluid
MH  - Isoelectric Focusing
MH  - Male
MH  - Muscle Spasticity/cerebrospinal fluid/epidemiology/immunology
MH  - Oligoclonal Bands
MH  - Paraplegia/cerebrospinal fluid/*epidemiology/immunology
MH  - *Tropical Medicine
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
AID - 10.1002/ana.410230730 [doi]
PST - ppublish
SO  - Ann Neurol. 1988;23 Suppl:S127-32. doi: 10.1002/ana.410230730.