PMID- 28948342
OWN - NLM
STAT- MEDLINE
DCOM- 20180621
LR  - 20180621
IS  - 1432-069X (Electronic)
IS  - 0340-3696 (Linking)
VI  - 309
IP  - 10
DP  - 2017 Dec
TI  - Pediatric mycosis fungoides: a study of the human leukocyte antigen system among 
      Israeli Jewish patients.
PG  - 851-856
LID - 10.1007/s00403-017-1783-7 [doi]
AB  - Pediatric mycosis fungoides (MF) is a rare disease characterized by 
      over-representation of atypical clinical variants, with a different prognosis 
      from adult MF. Several human leukocyte antigen (HLA) alleles have been associated 
      with MF in certain adult populations, including Israeli Jews. However, HLA data 
      on pediatric MF as a group are lacking. To evaluate the possible association of 
      the HLA system with pediatric MF, 59 Israeli Jewish patients diagnosed with MF at 
      age </= 18 years underwent high- and intermediate-resolution genotyping for HLA 
      class I (HLA-A*, HLA-B*) and class II (HLA-DRB1*, DQB1*) loci. The results were 
      compared with data on 4169 umbilical cord blood units retrieved from a public 
      cord blood bank in Jerusalem and samples from 252 healthy, unrelated Israeli 
      Jewish volunteers. No statistically significant associations were found between 
      pediatric MF and any of the alleles examined except HLA-B*73. However, given the 
      extremely low frequency of B*73 in both the control group (0.1%) and the study 
      group (2%), the biological significance of this finding is questionable. Further 
      subgroup analyses by ethnicity (Ashkenazi and non-Ashkenazi) and 
      clinicopathologic variant (follicular and non-follicular) yielded no significant 
      between-group differences. These results suggest that the associations with the 
      HLA system, reported previously in adult MF, do not hold true for pediatric MF. 
      Thus, pediatric MF differs from its adult counterpart not only in clinical 
      manifestations and course, but apparently also in the underlying 
      immuno-pathogenetic mechanism.
FAU - Reiter, Ofer
AU  - Reiter O
AD  - Department of Dermatology, Rabin Medical Center, Beilinson Hospital, 4941492, 
      Petach Tikva, Israel.
FAU - Ben Amitai, Dan
AU  - Ben Amitai D
AD  - Dermatology Unit, Schneider Children's Medical Center of Israel, Petach Tikva, 
      Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Amitay-Laish, Iris
AU  - Amitay-Laish I
AD  - Department of Dermatology, Rabin Medical Center, Beilinson Hospital, 4941492, 
      Petach Tikva, Israel.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
FAU - Israeli, Moshe
AU  - Israeli M
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
AD  - Tissue Typing Laboratory, Rabin Medical Center, Beilinson Hospital, Petach Tikva, 
      Israel.
FAU - Pavlovsky, Lev
AU  - Pavlovsky L
AD  - Department of Dermatology, Rabin Medical Center, Beilinson Hospital, 4941492, 
      Petach Tikva, Israel.
FAU - Hodak, Emmilia
AU  - Hodak E
AD  - Department of Dermatology, Rabin Medical Center, Beilinson Hospital, 4941492, 
      Petach Tikva, Israel. hodake@post.tau.ac.il.
AD  - Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. 
      hodake@post.tau.ac.il.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170925
PL  - Germany
TA  - Arch Dermatol Res
JT  - Archives of dermatological research
JID - 8000462
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age Factors
MH  - Alleles
MH  - Female
MH  - Fetal Blood
MH  - Gene Frequency
MH  - Genotyping Techniques
MH  - Healthy Volunteers
MH  - Histocompatibility Antigens Class I/*genetics
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - Israel
MH  - Jews/*genetics
MH  - Male
MH  - Mycosis Fungoides/*genetics
MH  - Skin Neoplasms/*genetics
OTO - NOTNLM
OT  - Cutaneous T cell lymphoma
OT  - Human histocompatibility complex
OT  - Juvenile mycosis fungoides
EDAT- 2017/09/28 06:00
MHDA- 2018/06/22 06:00
CRDT- 2017/09/27 06:00
PHST- 2017/05/25 00:00 [received]
PHST- 2017/09/14 00:00 [accepted]
PHST- 2017/09/06 00:00 [revised]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2018/06/22 06:00 [medline]
PHST- 2017/09/27 06:00 [entrez]
AID - 10.1007/s00403-017-1783-7 [pii]
AID - 10.1007/s00403-017-1783-7 [doi]
PST - ppublish
SO  - Arch Dermatol Res. 2017 Dec;309(10):851-856. doi: 10.1007/s00403-017-1783-7. Epub 
      2017 Sep 25.