PMID- 2894882
OWN - NLM
STAT- MEDLINE
DCOM- 19880427
LR  - 20190705
IS  - 0007-1323 (Print)
IS  - 0007-1323 (Linking)
VI  - 75
IP  - 2
DP  - 1988 Feb
TI  - Total pancreatectomy in the MEN-1 syndrome.
PG  - 154-7
AB  - A family with the multiple endocrine neoplasia Type 1 (MEN-1) syndrome, followed 
      over three generations, is presented. In the first generation, one family member 
      died after a history indicating Zollinger-Ellison syndrome. In the second 
      generation endocrine pancreatic tumours were diagnosed or suspected in three out 
      of five members. In the third generation, five out of seven members were 
      investigated and four of these had positive tests at hormonal screening. Of 
      particular diagnostic value in this family was the determination of peripheral 
      serum levels of proinsulin and C-peptide, which were used as tumour markers both 
      for diagnosis and in the postoperative follow-up. Two members in the third 
      generation have been successfully managed by total pancreatectomy. A MEN-1 
      patient with malignant pancreatic tumours should be considered for total 
      pancreatectomy if the pancreatic disease has caused high morbidity and mortality 
      within the family. This is especially pertinent if the patient has multiple 
      malignant tumours.
FAU - Tisell, L E
AU  - Tisell LE
AD  - Department of Surgery I, University of Goteborg, Sweden.
FAU - Ahlman, H
AU  - Ahlman H
FAU - Jansson, S
AU  - Jansson S
FAU - Grimelius, L
AU  - Grimelius L
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia/*genetics/surgery
MH  - *Pancreatectomy
MH  - Pancreatic Neoplasms/*genetics/surgery
MH  - Pedigree
EDAT- 1988/02/01 00:00
MHDA- 1988/02/01 00:01
CRDT- 1988/02/01 00:00
PHST- 1988/02/01 00:00 [pubmed]
PHST- 1988/02/01 00:01 [medline]
PHST- 1988/02/01 00:00 [entrez]
AID - 10.1002/bjs.1800750222 [doi]
PST - ppublish
SO  - Br J Surg. 1988 Feb;75(2):154-7. doi: 10.1002/bjs.1800750222.