PMID- 28949009 OWN - NLM STAT- MEDLINE DCOM- 20190517 LR - 20190517 IS - 1479-828X (Electronic) IS - 0004-8666 (Linking) VI - 58 IP - 3 DP - 2018 Jun TI - Nausea and vomiting of pregnancy: Effects on quality of life and day-to-day function. PG - 278-290 LID - 10.1111/ajo.12714 [doi] AB - AIMS: To investigate the effect of nausea and vomiting of pregnancy (NVP) on quality of life (QoL) and activities of daily living/socioeconomic function in a contemporary Australian setting. MATERIALS AND METHODS: Observational, single centre prospective cohort study using validated survey instruments in pregnant women at 9-16 weeks gestation at a tertiary metropolitan women's hospital in Sydney, Australia. QoL measured by the Short-Form Health Survey (SF-12) was compared between those with and without NVP. NVP severity scores were correlated with QoL scores, work patterns and medication use. RESULTS: Of 116 participants, 72% had NVP, with no baseline (including mental health) differences between women with or without NVP. As classified by modified Pregnancy-Unique-Quantified-Emesis (PUQE) survey, 42% had mild symptoms, 55% moderate and 1% severe. SF-12 Physical Component Summary (PCS) scores were significantly lower for those with NVP (P < 0.001), but not Mental Component Summary (MCS) scores (P = 0.11). Decreasing QoL was associated with increasing NVP severity (P < 0.001), most markedly in the physical domain (P < 0.001). Only 39% of women used any NVP treatment and 15% pharmacotherapy. Most used treatments were vitamin B(6) , ginger, metoclopramide and natural remedies. Significantly more women with NVP required time off work (45% vs 16%, P = 0.003). CONCLUSIONS: NVP is a physically morbid disease, affecting most pregnancies. NVP has a significant detrimental impact on QoL, especially physical QoL and work function. Despite this, we found low treatment utilisation, even in those with moderate/severe symptoms. Women should be encouraged to seek assistance for NVP and further education is required to improve practitioner awareness and management. CI - (c) 2017 The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. FAU - Tan, Amelia AU - Tan A AUID- ORCID: 0000-0002-1317-2800 AD - School of Women's and Children's Health, UNSW Medicine, Sydney, NSW, Australia. FAU - Lowe, Sandra AU - Lowe S AD - School of Women's and Children's Health, UNSW Medicine, Sydney, NSW, Australia. AD - Department of Obstetrics, Royal Hospital for Women, Randwick, NSW, Australia. FAU - Henry, Amanda AU - Henry A AUID- ORCID: 0000-0002-7351-8922 AD - School of Women's and Children's Health, UNSW Medicine, Sydney, NSW, Australia. AD - Department of Maternal-Fetal Medicine, Royal Hospital for Women, Randwick, NSW, Australia. AD - Women's and Children's Health, St George Hospital, Kogarah, NSW, Australia. LA - eng PT - Journal Article PT - Observational Study DEP - 20170926 PL - Australia TA - Aust N Z J Obstet Gynaecol JT - The Australian & New Zealand journal of obstetrics & gynaecology JID - 0001027 RN - 0 (Antiemetics) RN - L4YEB44I46 (Metoclopramide) SB - IM MH - Activities of Daily Living MH - Antiemetics/therapeutic use MH - Cohort Studies MH - Female MH - Humans MH - Hyperemesis Gravidarum/drug therapy/*psychology MH - Metoclopramide/therapeutic use MH - New South Wales MH - Pregnancy MH - Pregnancy Complications/drug therapy/*psychology MH - *Prenatal Care MH - Prospective Studies MH - *Quality of Life MH - Surveys and Questionnaires OTO - NOTNLM OT - antiemetics OT - hyperemesis gravidarum OT - pregnancy OT - quality of life OT - vomiting EDAT- 2017/09/28 06:00 MHDA- 2019/05/18 06:00 CRDT- 2017/09/27 06:00 PHST- 2017/03/08 00:00 [received] PHST- 2017/08/11 00:00 [accepted] PHST- 2017/09/28 06:00 [pubmed] PHST- 2019/05/18 06:00 [medline] PHST- 2017/09/27 06:00 [entrez] AID - 10.1111/ajo.12714 [doi] PST - ppublish SO - Aust N Z J Obstet Gynaecol. 2018 Jun;58(3):278-290. doi: 10.1111/ajo.12714. Epub 2017 Sep 26.