PMID- 28949372 OWN - NLM STAT- MEDLINE DCOM- 20180530 LR - 20180530 IS - 1791-244X (Electronic) IS - 1107-3756 (Linking) VI - 40 IP - 5 DP - 2017 Nov TI - Physalis peruviana L. inhibits airway inflammation induced by cigarette smoke and lipopolysaccharide through inhibition of extracellular signal-regulated kinase and induction of heme oxygenase-1. PG - 1557-1565 LID - 10.3892/ijmm.2017.3139 [doi] AB - Physalis peruviana L. (PP) is a medicinal herb that has been confirmed to have several biological activities, including anticancer, antioxidant and anti-inflammatory properties. The aim of the present study was to evaluate the protective effect of PP on cigarette smoke (CS)- and lipopolysaccharide (LPS)-induced pulmonary inflammation. Treatment with PP significantly reduced the influx of inflammatory cells in the bronchoalveolar lavage fluid (BALF) and lung of mice with CS- and LPS-induced pulmonary inflammation. PP also decreased the levels of reactive oxygen species (ROS) and pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) in the BALF. PP effectively attenuated the expression of monocyte chemoattractant protein-1 (MCP-1) and the activation of extracellular signal-regulated kinase (ERK) in the lung. In addition, nuclear factor erythroid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression were increased by PP treatment. In an in vitro experiment, PP reduced the mRNA expression of TNF-alpha and MCP-1, and the activation of ERK in CS extract-stimulated A549 epithelial cells. Furthermore, PP increased the activation of Nrf2 and the expression of HO-1 in A549 cells. These findings suggest that PP has a therapeutic potential for the treatment of pulmonary inflammatory diseases, such as chronic obstructive pulmonary disease. FAU - Park, Hyun Ah AU - Park HA AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Lee, Jae-Won AU - Lee JW AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Kwon, Ok-Kyoung AU - Kwon OK AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Lee, Gilhye AU - Lee G AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Lim, Yourim AU - Lim Y AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Kim, Jung Hee AU - Kim JH AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Paik, Jin-Hyub AU - Paik JH AD - International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea. FAU - Choi, Sangho AU - Choi S AD - International Biological Material Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea. FAU - Paryanto, Imam AU - Paryanto I AD - Center for Pharmaceutical and Medical Technology, The Agency for the Assessment and Application of Technology (BPPT), Tangerang, Banten 15314, Indonesia. FAU - Yuniato, Prasetyawan AU - Yuniato P AD - Center for Pharmaceutical and Medical Technology, The Agency for the Assessment and Application of Technology (BPPT), Tangerang, Banten 15314, Indonesia. FAU - Kim, Doo-Young AU - Kim DY AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Ryu, Hyung Won AU - Ryu HW AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Oh, Sei-Ryang AU - Oh SR AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. FAU - Lee, Seung Jin AU - Lee SJ AD - College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea. FAU - Ahn, Kyung-Seop AU - Ahn KS AD - Natural Medicine Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Chungbuk 28116, Republic of Korea. LA - eng PT - Journal Article DEP - 20170915 PL - Greece TA - Int J Mol Med JT - International journal of molecular medicine JID - 9810955 RN - 0 (Biomarkers) RN - 0 (Chemokine CCL2) RN - 0 (Cytokines) RN - 0 (Inflammation Mediators) RN - 0 (Lipopolysaccharides) RN - 0 (Plant Extracts) RN - 0 (Reactive Oxygen Species) RN - EC 1.14.14.18 (Heme Oxygenase-1) RN - EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) SB - IM MH - Animals MH - Biomarkers MH - Bronchoalveolar Lavage Fluid/cytology MH - Cell Line, Tumor MH - Chemokine CCL2/metabolism MH - Cytokines/metabolism MH - Disease Models, Animal MH - Extracellular Signal-Regulated MAP Kinases/*metabolism MH - Gene Expression Regulation MH - Heme Oxygenase-1/genetics/*metabolism MH - Humans MH - Inflammation/*etiology/*metabolism/pathology MH - Inflammation Mediators MH - Leukocytes/metabolism/pathology MH - Lipopolysaccharides/*adverse effects MH - Male MH - Mice MH - Neutrophil Infiltration MH - Neutrophils/metabolism/pathology MH - Physalis/*chemistry MH - Plant Extracts/chemistry/*pharmacology MH - Reactive Oxygen Species MH - Respiratory Mucosa/metabolism MH - Respiratory Tract Diseases/etiology/metabolism/pathology MH - Smoking/*adverse effects EDAT- 2017/09/28 06:00 MHDA- 2018/05/31 06:00 CRDT- 2017/09/27 06:00 PHST- 2017/04/04 00:00 [received] PHST- 2017/09/08 00:00 [accepted] PHST- 2017/09/28 06:00 [pubmed] PHST- 2018/05/31 06:00 [medline] PHST- 2017/09/27 06:00 [entrez] AID - 10.3892/ijmm.2017.3139 [doi] PST - ppublish SO - Int J Mol Med. 2017 Nov;40(5):1557-1565. doi: 10.3892/ijmm.2017.3139. Epub 2017 Sep 15.