PMID- 28951335
OWN - NLM
STAT- MEDLINE
DCOM- 20190108
LR  - 20190108
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 146
DP  - 2018 Dec
TI  - The risk of type 2 diabetes mellitus according to 2-h plasma glucose level: The 
      Korean Genome and Epidemiology Study (KoGES).
PG  - 130-137
LID - S0168-8227(17)30547-8 [pii]
LID - 10.1016/j.diabres.2017.08.002 [doi]
AB  - BACKGROUND: Although impaired glucose tolerance (IGT) is a definite risk factor 
      for type 2 diabetes mellitus (T2DM), there is limited information about the risk 
      stratification for incident T2DM within IGT group. Thus, we aimed to evaluate the 
      incidental risk for T2DM according to 2-h plasma glucose (2-h PG) level of oral 
      glucose tolerance test (OGTT) and phenotype of IGT. METHODS: 7654 Korean 
      participated in the Korean Genome and Epidemiology Study (KoGES) were stratified 
      by 2-h PG levels of OGTT, and followed up for 63,665 person-years. Cox 
      proportional hazards model was used to calculate the hazard ratios (HRs) and 95% 
      confidential interval (CI) for T2DM according to 2-h PG levels of OGTT with 
      adjustment for multiple covariates. Subgroup analysis was performed by gender and 
      the presence of impaired fasting glucose (IFG) or not. RESULTS: Within IGT, the 
      adjusted HRs for T2DM significantly increased proportionally to 2-h PG level 
      [<140mg/dL: reference, 140-159mg/dL: 3.07 (2.67-3.54), 160-179mg/dL: 5.44 (CI 
      4.66-6.34), 180-199mg/dL: 7.91 (CI 6.53-9.59)]. IGT combined with IFG had the 
      profoundly increased HRs than isolated IFG. Even within normal glucose tolerance 
      (NGT), 2-h PG level>/=120mg/dL had the higher risk for T2DM than other NGT groups. 
      These associations were more dominant in male than female. CONCLUSION: The 
      highest level of 2h-PG (180-199mg/dL) in IGT and IGT with IFG were strong 
      predictor for T2DM. 2-h PG of 120-139mg/dL was more significantly associated with 
      T2DM within NGT, and male was more susceptible for T2DM than female.
CI  - Copyright (c) 2017. Published by Elsevier B.V.
FAU - Park, Sung Keun
AU  - Park SK
AD  - Center for Cohort Studies, Total Healthcare Center, Kangbuk Samsung Hospital, 
      Sungkyunkwan University, School of Medicine, Seoul, Republic of Korea.
FAU - Ryoo, Jae-Hong
AU  - Ryoo JH
AD  - Departments of Preventive Medicine, School of Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Oh, Chang-Mo
AU  - Oh CM
AD  - Departments of Preventive Medicine, School of Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Choi, Joong-Myung
AU  - Choi JM
AD  - Departments of Preventive Medicine, School of Medicine, Kyung Hee University, 
      Seoul, Republic of Korea.
FAU - Choi, Young-Jun
AU  - Choi YJ
AD  - Department of Dermatology, Sungkyunkwan University, School of Medicine, Kangbuk 
      Samsung Hospital, Seoul, Republic of Korea.
FAU - Lee, Keum Ok
AU  - Lee KO
AD  - Department of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of 
      Korea.
FAU - Jung, Ju Young
AU  - Jung JY
AD  - Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University, 
      School of Medicine, Seoul, Republic of Korea. Electronic address: 
      jjy0501@naver.com.
LA  - eng
PT  - Journal Article
DEP - 20170809
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Blood Glucose/analysis/*metabolism
MH  - Diabetes Mellitus, Type 2/*blood/epidemiology
MH  - Female
MH  - Genomics/*methods
MH  - Glucose Intolerance/*blood
MH  - Glucose Tolerance Test/*methods
MH  - Humans
MH  - Korea
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - Impaired fasting glucose
OT  - Impaired glucose tolerance
OT  - Oral glucose tolerance test
EDAT- 2017/09/28 06:00
MHDA- 2019/01/09 06:00
CRDT- 2017/09/28 06:00
PHST- 2017/04/05 00:00 [received]
PHST- 2017/07/26 00:00 [revised]
PHST- 2017/08/03 00:00 [accepted]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2019/01/09 06:00 [medline]
PHST- 2017/09/28 06:00 [entrez]
AID - S0168-8227(17)30547-8 [pii]
AID - 10.1016/j.diabres.2017.08.002 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Dec;146:130-137. doi: 
      10.1016/j.diabres.2017.08.002. Epub 2017 Aug 9.