PMID- 28951522
OWN - NLM
STAT- MEDLINE
DCOM- 20180611
LR  - 20221207
IS  - 1573-4935 (Electronic)
IS  - 0144-8463 (Print)
IS  - 0144-8463 (Linking)
VI  - 37
IP  - 5
DP  - 2017 Oct 31
TI  - IL-10 -1082 A>G (rs1800896) polymorphism confers susceptibility to pulmonary 
      tuberculosis in Caucasians but not in Asians and Africans: a meta-analysis.
LID - BSR20170240 [pii]
LID - 10.1042/BSR20170240 [doi]
AB  - BACKGROUND: Earlier studies have shown that interlukin-10 (IL-10) -1082 A>G gene 
      polymorphism is implicated in susceptibility to pulmonary tuberculosis (PTB), but 
      their results are inconsistent and inconclusive. In the present study, a 
      meta-analysis was performed to analyze the potential association between IL-10 
      -1082 A>G gene polymorphism and PTB susceptibility. METHODS: A quantitative 
      synthesis was done using PubMed (Medline), EMBASE, and Google Scholar web 
      databases search and meta-analysis was performed by calculating pooled odds 
      ratios (ORs) and 95% confidence intervals (95% CIs) for all the genetic models. 
      RESULTS: A total of 22 eligible studies comprising 4956 PTB cases and 6428 
      healthy controls were included in the analysis. We did not observe any increased 
      or decreased risk of PTB in allelic contrast (G vs. A: P=0.985; OR = 1.001, 95% 
      CI = 0.863-1.162), homozygous (GG vs. AA: P=0.889; OR = 1.029, 95% CI = 
      0.692-1.529), heterozygous (GA vs. AA: P=0.244; OR = 0.906, 95% CI = 
      0.767-1.070), dominant (GG + AG vs. AA: P=0.357; OR = 1.196, 95% CI = 
      0.817-1.752), and recessive (GG vs. AA + AG: P=0.364; OR = 0.921, 95% CI = 
      0.771-1.100) genetic models. Likewise, no association of IL-10 -1082 A>G 
      polymorphism with PTB risk was observed in Asian and African population for all 
      the genetic models. Interestingly, the dominant model (GG + AG vs. AA: P=0.004; 
      OR = 1.694, 95% CI = 1.183-2.425) demonstrated increased risk of PTB in Caucasian 
      population. CONCLUSIONS: This meta-analysis concludes that IL-10 -1082 A>G gene 
      polymorphism is not significantly associated with overall, Asian and African 
      population. However, this polymorphism is associated with Caucasian population.
CI  - (c) 2017 The Author(s).
FAU - Areeshi, Mohammed Y
AU  - Areeshi MY
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan 45142, Saudi Arabia.
FAU - Mandal, Raju K
AU  - Mandal RK
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan 45142, Saudi Arabia.
FAU - Dar, Sajad A
AU  - Dar SA
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan 45142, Saudi Arabia.
AD  - The University College of Medical Sciences and GTB Hospital, University of Delhi, 
      Delhi 110095, India.
FAU - Jawed, Arshad
AU  - Jawed A
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan 45142, Saudi Arabia.
FAU - Wahid, Mohd
AU  - Wahid M
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan 45142, Saudi Arabia.
FAU - Lohani, Mohtashim
AU  - Lohani M
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan 45142, Saudi Arabia.
FAU - Panda, Aditya K
AU  - Panda AK
AD  - Centre for Life Sciences, Central University of Jharkhand, Ranchi 835205, 
      Jharkhand, India.
FAU - Mishra, Bhartendu N
AU  - Mishra BN
AD  - Department of Biotechnology, Institute of Engineering and Technology, Lucknow 
      226021, Uttar Pradesh, India.
FAU - Akhter, Naseem
AU  - Akhter N
AD  - Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha 
      University, Albaha 65431, Saudi Arabia.
FAU - Haque, Shafiul
AU  - Haque S
AD  - Research and Scientific Studies Unit, College of Nursing and Allied Health 
      Sciences, Jazan University, Jazan 45142, Saudi Arabia shafiul.haque@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20171027
PL  - England
TA  - Biosci Rep
JT  - Bioscience reports
JID - 8102797
RN  - 0 (IL10 protein, human)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Asian People
MH  - Black People/genetics
MH  - Female
MH  - *Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Interleukin-10/*genetics
MH  - Male
MH  - Polymorphism, Single Nucleotide/genetics
MH  - Risk Factors
MH  - Tuberculosis, Pulmonary/epidemiology/*genetics/pathology
MH  - White People/genetics
PMC - PMC5658633
OTO - NOTNLM
OT  - IL-10
OT  - Meta-analysis
OT  - genetic models
OT  - polymorphism
OT  - pulmonary tuberculosis
COIS- The authors declare that there are no competing interests associated with the 
      manuscript.
EDAT- 2017/09/28 06:00
MHDA- 2018/06/12 06:00
PMCR- 2017/10/27
CRDT- 2017/09/28 06:00
PHST- 2017/03/11 00:00 [received]
PHST- 2017/09/14 00:00 [revised]
PHST- 2017/09/20 00:00 [accepted]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2018/06/12 06:00 [medline]
PHST- 2017/09/28 06:00 [entrez]
PHST- 2017/10/27 00:00 [pmc-release]
AID - BSR20170240 [pii]
AID - 10.1042/BSR20170240 [doi]
PST - epublish
SO  - Biosci Rep. 2017 Oct 27;37(5):BSR20170240. doi: 10.1042/BSR20170240. Print 2017 
      Oct 31.