PMID- 28951620
OWN - NLM
STAT- MEDLINE
DCOM- 20190716
LR  - 20221207
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 7
IP  - 1
DP  - 2017 Sep 26
TI  - Lipoprotein-associated Phospholipase A2 Is Associated with Risk of Mild Cognitive 
      Impairment in Chinese Patients with Type 2 Diabetes.
PG  - 12311
LID - 10.1038/s41598-017-12515-z [doi]
LID - 12311
AB  - Type 2 diabetes mellitus (T2DM) is a low-grade chronic inflammatory diseases, 
      which have been implicated in the pathogenesis of cognitive decline. We aim to 
      evaluate associations between inflammatory markers and the risk of mild cognitive 
      impairment (MCI) in T2DM. This study of 140 diabetic patients involved 71 with 
      MCI and 69 controls. Clinical parameters, neuropsychological tests, high 
      sensitivity C reactive protein (hsCRP), interleukin-6 (IL-6), 
      lipoprotein-associated Phospholipase A2 (Lp-PLA2) mass and activity were 
      measured. The results showed significantly higher plasma hsCRP, IL-6, Lp-PLA2 
      mass and activity in MCI group compared to controls. In T2DM with MCI, the 
      Montreal Cognitive Assessment (MoCA) score was positively correlated with 
      education level and high-density lipoprotein cholesterol (HDL-c), but inversely 
      correlated with age, glycosylated hemoglobin, intima-media thickness (IMT), 
      hsCRP, IL-6, and Lp-PLA2 mass and activity. Correlation analysis showed that both 
      plasma Lp-PLA2 mass and activity were positively correlated with total 
      cholesterol, low-density lipoprotein cholesterol, and IMT but negatively 
      associated with MoCA score. Multivariable logistic regression analysis indicated 
      higher hsCRP, Lp-PLA2 mass, Lp-PLA2 activity, and lower HDL-c to be independent 
      risk factors increasing the possibility of MCI in T2DM. In conclusion, plasma 
      Lp-PLA2 and hsCRP were found to be associated with the risk of MCI among T2DM 
      patients.
FAU - Cai, Rongrong
AU  - Cai R
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
AD  - Medical school of Southeast University, Nanjing, China.
FAU - Huang, Rong
AU  - Huang R
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Han, Jing
AU  - Han J
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Sun, Haixia
AU  - Sun H
AD  - Department of Endocrinology, Yixing People's Hospital, Yixing, China.
FAU - Sun, Jie
AU  - Sun J
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Xia, Wenqing
AU  - Xia W
AD  - Department of Endocrinology, Nanjing First Hospital, Nanjing Medical University, 
      Nanjing, China.
FAU - Tian, Sai
AU  - Tian S
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Dong, Xue
AU  - Dong X
AD  - Department of Endocrinology, Wuxi No.2 People's Hospital, Wuxi, China.
FAU - Shen, Yanjue
AU  - Shen Y
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China.
FAU - Wang, Shaohua
AU  - Wang S
AD  - Department of Endocrinology, The Affiliated ZhongDa Hospital of Southeast 
      University, Nanjing, China. gyjwsh@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170926
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - EC 3.1.1.47 (1-Alkyl-2-acetylglycerophosphocholine Esterase)
RN  - EC 3.1.1.47 (PLA2G7 protein, human)
SB  - IM
MH  - 1-Alkyl-2-acetylglycerophosphocholine Esterase/*blood/metabolism
MH  - Adult
MH  - Aged
MH  - Asian People
MH  - Biomarkers/blood
MH  - C-Reactive Protein/analysis/metabolism
MH  - Case-Control Studies
MH  - Cognitive Dysfunction/*blood/etiology
MH  - Diabetes Mellitus, Type 2/blood/*complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
PMC - PMC5615059
COIS- The authors declare that they have no competing interests.
EDAT- 2017/09/28 06:00
MHDA- 2019/07/17 06:00
PMCR- 2017/09/26
CRDT- 2017/09/28 06:00
PHST- 2016/09/05 00:00 [received]
PHST- 2017/09/12 00:00 [accepted]
PHST- 2017/09/28 06:00 [entrez]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2019/07/17 06:00 [medline]
PHST- 2017/09/26 00:00 [pmc-release]
AID - 10.1038/s41598-017-12515-z [pii]
AID - 12515 [pii]
AID - 10.1038/s41598-017-12515-z [doi]
PST - epublish
SO  - Sci Rep. 2017 Sep 26;7(1):12311. doi: 10.1038/s41598-017-12515-z.