PMID- 28951710 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20200930 IS - 1642-395X (Print) IS - 2299-0046 (Electronic) IS - 1642-395X (Linking) VI - 34 IP - 4 DP - 2017 Aug TI - Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism. PG - 346-349 LID - 10.5114/ada.2017.69315 [doi] AB - INTRODUCTION: Symptomatic dermographism (SD) is the most common form of physical urticaria. However, the role of neuroimmune mechanisms in SD is unclear. AIM: To investigate circulating levels of brain-derived neurotrophic factor (BDNF) in symptomatic dermographism. MATERIAL AND METHODS: Thirty-two patients suffering from SD and 33 healthy subjects were included in the study. Serum BDNF levels were determined by a human enzyme-linked immunoassay (ELISA) kit. The serum C-reactive protein concentration and eosinophil counts in peripheral blood were evaluated. RESULTS: The BDNF serum levels were detectable in both SD patients and healthy controls. The BDNF serum levels were significantly higher in patients with SD compared with healthy controls (p = 0.004). There was a positive but weak correlation between serum BDNF and CRP levels; it was not statistically significant (r = 0.211, p = 0.255). There was also a positive but weak correlation between serum BDNF and eosinophil counts; it was not statistically significant (r = 0.271, p = 0.141). CONCLUSIONS: The present study shows that BDNF is increased in the serum levels of patients with SD, suggesting a role for BDNF in the pathophysiology of this disorder. FAU - Erpolat, Seval AU - Erpolat S AD - Department of Dermatology, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey. FAU - Celik, Huseyin Tugrul AU - Celik HT AD - Department of Biochemistry, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey. FAU - Bozkurt, Bulent AU - Bozkurt B AD - Division of Allergy, Department of Chest Medicine, Faculty of Medicine, Turgut Ozal University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20170802 PL - Poland TA - Postepy Dermatol Alergol JT - Postepy dermatologii i alergologii JID - 101168357 PMC - PMC5560183 OTO - NOTNLM OT - brain-derived neurotrophic factor OT - neurotrophin OT - symptomatic dermographism EDAT- 2017/09/28 06:00 MHDA- 2017/09/28 06:01 PMCR- 2017/08/01 CRDT- 2017/09/28 06:00 PHST- 2016/03/11 00:00 [received] PHST- 2016/06/01 00:00 [accepted] PHST- 2017/09/28 06:00 [entrez] PHST- 2017/09/28 06:00 [pubmed] PHST- 2017/09/28 06:01 [medline] PHST- 2017/08/01 00:00 [pmc-release] AID - 30420 [pii] AID - 10.5114/ada.2017.69315 [doi] PST - ppublish SO - Postepy Dermatol Alergol. 2017 Aug;34(4):346-349. doi: 10.5114/ada.2017.69315. Epub 2017 Aug 2.