PMID- 28952018
OWN - NLM
STAT- MEDLINE
DCOM- 20180213
LR  - 20181113
IS  - 1826-6983 (Electronic)
IS  - 0033-8362 (Linking)
VI  - 123
IP  - 2
DP  - 2018 Feb
TI  - Effects of serial macrocyclic-based contrast materials gadoterate meglumine and 
      gadobutrol administrations on gadolinium-related dentate nuclei signal increases 
      in unenhanced T1-weighted brain: a retrospective study in 158 multiple sclerosis 
      (MS) patients.
PG  - 125-134
LID - 10.1007/s11547-017-0816-9 [doi]
AB  - PURPOSE: To perform T1 signal intensity (SI) measurements in the dentate nuclei 
      of adult patients with confirmed multiple sclerosis (MS) after serial 
      administrations of the macrocyclic gadolinium-based contrast agents (GBCAs), 
      gadoterate meglumine and gadobutrol. MATERIALS AND METHODS: This retrospective 
      study was approved by the institutional review board and informed consent was 
      waived. A review of our PACS database for the period from March 1, 2007 to July 
      31, 2016 revealed 158 confirmed MS patients who received exclusively either 
      gadoterate meglumine (n = 81) or gadobutrol (n = 77) for diagnosis and follow-up. 
      SI measurements on unenhanced T1-weighted images were performed on all scans of 
      all patients and at regions of interest (ROIs) positioned on the dentate nucleus 
      (DN) and pons. The dentate nucleus-to-pons (DNP) T1-SI ratio was subsequently 
      calculated. Unpaired T test and regression analysis were used to evaluate 
      statistical differences. RESULTS: An increase in DNP was noted between the first 
      and last MR examinations for both gadoterate meglumine (0.0032 +/- 0.0216) and 
      gadobutrol (0.0019 +/- 0.0346). Although the differences were not statistically 
      significant based across the entire patient population, visible T1 hyperintensity 
      in the DN was noted in approximately one-third of all patients in each group that 
      received at least five administrations of either GBCA. CONCLUSIONS: SI increases 
      on unenhanced T1-weighted images possibly indicative of gadolinium retention 
      occur after serial administrations of the macrocyclic GBCAs, gadoterate meglumine 
      and gadobutrol.
FAU - Splendiani, Alessandra
AU  - Splendiani A
AUID- ORCID: 0000-0002-2188-3506
AD  - Radiology, Department of Biotechnological and Applied Clinical Sciences, 
      University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy. 
      alessandra.splendiani@cc.univaq.it.
FAU - Perri, Marco
AU  - Perri M
AD  - Radiology, Department of Biotechnological and Applied Clinical Sciences, 
      University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
FAU - Marsecano, Claudia
AU  - Marsecano C
AD  - Radiology, Department of Biotechnological and Applied Clinical Sciences, 
      University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
FAU - Vellucci, Valentina
AU  - Vellucci V
AD  - Radiology, Department of Biotechnological and Applied Clinical Sciences, 
      University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
FAU - Michelini, Giulia
AU  - Michelini G
AD  - Radiology, Department of Biotechnological and Applied Clinical Sciences, 
      University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
FAU - Barile, Antonio
AU  - Barile A
AD  - Radiology, Department of Biotechnological and Applied Clinical Sciences, 
      University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
FAU - Di Cesare, Ernesto
AU  - Di Cesare E
AD  - Radiology, Department of Biotechnological and Applied Clinical Sciences, 
      University of L'Aquila, Via Vetoio, 67100, L'Aquila, Italy.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170927
PL  - Italy
TA  - Radiol Med
JT  - La Radiologia medica
JID - 0177625
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
RN  - 6HG8UB2MUY (Meglumine)
RN  - AU0V1LM3JT (Gadolinium)
RN  - L0ND3981AG (gadoterate meglumine)
SB  - IM
CIN - Radiol Med. 2018 Jun;123(6):432-433. PMID: 29476438
MH  - Adult
MH  - Brain/diagnostic imaging
MH  - Cerebellar Nuclei/*diagnostic imaging
MH  - Contrast Media/*pharmacology
MH  - Female
MH  - Gadolinium/pharmacology
MH  - Humans
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Meglumine/*pharmacology
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnostic imaging
MH  - Organometallic Compounds/*pharmacology
MH  - Predictive Value of Tests
MH  - Retrospective Studies
MH  - Sensitivity and Specificity
OTO - NOTNLM
OT  - Gadolinium
OT  - Gadolinium-related dentate nuclei signal
OT  - MRI
OT  - Multiple sclerosis
EDAT- 2017/09/28 06:00
MHDA- 2018/02/14 06:00
CRDT- 2017/09/28 06:00
PHST- 2017/01/10 00:00 [received]
PHST- 2017/09/13 00:00 [accepted]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2018/02/14 06:00 [medline]
PHST- 2017/09/28 06:00 [entrez]
AID - 10.1007/s11547-017-0816-9 [pii]
AID - 10.1007/s11547-017-0816-9 [doi]
PST - ppublish
SO  - Radiol Med. 2018 Feb;123(2):125-134. doi: 10.1007/s11547-017-0816-9. Epub 2017 
      Sep 27.