PMID- 28952291
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2008-823X (Electronic)
IS  - 1028-852X (Print)
IS  - 1028-852X (Linking)
VI  - 22
IP  - 2
DP  - 2018 Mar
TI  - High-Resolution HLA-A Typing in Normal Iranian Population.
PG  - 134-7
AB  - BACKGROUND: Human leukocyte antigen (HLA) gene is a highly polymorphic region. 
      HLA typing is required to match patients and donors for transplantation; 
      therefore, development of HLA registries is necessary for finding HLA match 
      donors. HLA system is highly informative, and numerous studies have been 
      conducted on HLA allele distribution in different populations. METHODS: In this 
      study, 100 unrelated Iranian individuals were typed for HLA-A locus using 
      sequence-based typing method. Samples were subjected to the PCR, followed by 
      Sanger sequencing and software analysis. RESULTS: A*02:01 (13%) and A*24:02 (12%) 
      were the two most frequent alleles, while A*01:14, A*02:05, A*02:11, A*02:34, 
      A*02:50, A*11:04, A*23:02, A*24:34, A*25:01, A*26:09, A*26:43, A*29:67, A*30:54, 
      A*31:02, A*31:66, A*32:03, A*32:04, A*33:03, and A*66:15 alleles had the least 
      frequencies (1%). CONCLUSION: This is the first report of HLA-A allele level 
      typing in a randomized population of Iran and can be useful for development of 
      national registries of HLA-typed volunteer marrow donors and local cord blood 
      banks.
FAU - Hadadianpour, Azadeh
AU  - Hadadianpour A
AD  - Department of Biotechnology, College of Science, University of Tehran, Tehran, 
      Iran.
AD  - Kawsar Human Genetics Research Center, Tehran, Iran.
FAU - Samiee Aref, Mohammad Hasan
AU  - Samiee Aref MH
AD  - Department of Biotechnology, College of Science, University of Tehran, Tehran, 
      Iran.
AD  - Kawsar Human Genetics Research Center, Tehran, Iran.
FAU - Zeinali, Sirous
AU  - Zeinali S
AD  - Kawsar Human Genetics Research Center, Tehran, Iran.
AD  - Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20170927
PL  - Iran
TA  - Iran Biomed J
JT  - Iranian biomedical journal
JID - 9814853
PMC - PMC5786660
OTO - NOTNLM
OT  - HLA
OT  - Unrelated donors
OT  - Iran
COIS- CONFLICT OF INTEREST. None declared.
EDAT- 2017/09/28 06:00
MHDA- 2017/09/28 06:01
PMCR- 2018/03/01
CRDT- 2017/09/28 06:00
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2017/09/28 06:01 [medline]
PHST- 2017/09/28 06:00 [entrez]
PHST- 2018/03/01 00:00 [pmc-release]
AID - IBJ-22-134 [pii]
AID - 10.22034/ibj.22.2.134 [doi]
PST - ppublish
SO  - Iran Biomed J. 2018 Mar;22(2):134-7. doi: 10.22034/ibj.22.2.134. Epub 2017 Sep 
      27.