PMID- 28953199
OWN - NLM
STAT- MEDLINE
DCOM- 20190313
LR  - 20190624
IS  - 1538-943X (Electronic)
IS  - 1058-2916 (Linking)
VI  - 64
IP  - 3
DP  - 2018 May/Jun
TI  - The Utility of a Wireless Implantable Hemodynamic Monitoring System in Patients 
      Requiring Mechanical Circulatory Support.
PG  - 301-308
LID - 10.1097/MAT.0000000000000670 [doi]
AB  - Proper timing of left ventricular assist device (LVAD) implantation in advanced 
      heart failure patients is not well established and is an area of intense 
      interest. In addition, optimizing LVAD performance after implantation remains 
      difficult and represents a significant clinical need. Implantable hemodynamic 
      monitoring systems may provide physicians with the physiologic information 
      necessary to improve the timing of LVAD implantation as well as LVAD performance 
      when compared with current methods. The CardioMEMS Heart sensor Allows for 
      Monitoirng of Pressures to Improve Outcomes in NYHA Class III heart failure 
      patients (CHAMPION) Trial enrolled 550 previously hospitalized patients with New 
      York Heart Association (NYHA) class III heart failure. All patients were 
      implanted with a pulmonary artery (PA) pressure monitoring system and randomized 
      to a treatment and control groups. In the treatment group, physicians used the 
      hemodynamic information to make heart failure management decisions. This 
      information was not available to physicians for the control group. During an 
      average of 18 month randomized follow-up, 27 patients required LVAD implantation. 
      At the time of PA pressure sensor implantation, patients ultimately requiring 
      advanced therapy had higher PA pressures, lower systemic pressure, and similar 
      cardiac output measurements. Treatment and control patients in the LVAD subgroup 
      had similar clinical profiles at the time of enrollment. There was a trend toward 
      a shorter length of time to LVAD implantation in the treatment group when 
      hemodynamic information was available. After LVAD implantation, most treatment 
      group patients continued to provide physicians with physiologic information from 
      the hemodynamic monitoring system. As expected PA pressures declined 
      significantly post LVAD implant in all patients, but the magnitude of decline was 
      higher in patients with PA pressure monitoring. Implantable hemodynamic 
      monitoring appeared to improve the timing of LVAD implantation as well as 
      optimize LVAD performance when compared with current methods. Further studies are 
      necessary to evaluate these findings in a prospective manner.
FAU - Feldman, David S
AU  - Feldman DS
AD  - From the Division of Cardiovascular Medicine, University of Cincinnati Medical 
      Center, Cincinnati, Ohio.
AD  - Division of Cardiology, University of Berne, Bern, Switzerland.
FAU - Moazami, Nader
AU  - Moazami N
AD  - Cardiothoracic Surgery, Cleveland Clinic Foundation, Cleveland, Ohio.
FAU - Adamson, Philip B
AU  - Adamson PB
AD  - Section for Advanced Medical Therapies, St Jude Medical.
FAU - Vierecke, Juliane
AU  - Vierecke J
AD  - Division of Cardiology, University of Berne, Bern, Switzerland.
FAU - Raval, Nirav
AU  - Raval N
AD  - Florida Hospital Transplant Institute, Orlando, Florida.
FAU - Shreenivas, Satya
AU  - Shreenivas S
AD  - From the Division of Cardiovascular Medicine, University of Cincinnati Medical 
      Center, Cincinnati, Ohio.
FAU - Cabuay, Barry M
AU  - Cabuay BM
AD  - Department of Cardiology, Minneapolis Heart Institute, Minneapolis, Minnesota.
FAU - Jimenez, Javier
AU  - Jimenez J
AD  - Division of Cardiology, South Miami Hospital, South Miami, Florida.
FAU - Abraham, William T
AU  - Abraham WT
AD  - Division of Cardiovascular Medicine, The Ohio State University Medical Center, 
      Columbus, Ohio.
FAU - O'Connell, John B
AU  - O'Connell JB
AD  - Section for Advanced Medical Therapies, St Jude Medical.
FAU - Naka, Yoshifumi
AU  - Naka Y
AD  - Division of Cardiothoracic Surgery, Columbia University Medical Center, New York 
      City, New York.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - ASAIO J
JT  - ASAIO journal (American Society for Artificial Internal Organs : 1992)
JID - 9204109
SB  - IM
EIN - ASAIO J. 2018 Nov/Dec;64(6):e195. PMID: 30394909
MH  - Female
MH  - Heart Failure/*physiopathology/*therapy
MH  - *Heart-Assist Devices/adverse effects
MH  - Hemodynamic Monitoring/*instrumentation
MH  - Hemodynamics/physiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Wireless Technology/*instrumentation
EDAT- 2017/09/28 06:00
MHDA- 2019/03/14 06:00
CRDT- 2017/09/28 06:00
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2019/03/14 06:00 [medline]
PHST- 2017/09/28 06:00 [entrez]
AID - 10.1097/MAT.0000000000000670 [doi]
PST - ppublish
SO  - ASAIO J. 2018 May/Jun;64(3):301-308. doi: 10.1097/MAT.0000000000000670.