PMID- 28953631
OWN - NLM
STAT- MEDLINE
DCOM- 20171005
LR  - 20220330
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 96
IP  - 39
DP  - 2017 Sep
TI  - Thoracic paravertebral regional anesthesia for pain relief in patients with 
      breast cancer surgery.
PG  - e8107
LID - 10.1097/MD.0000000000008107 [doi]
LID - e8107
AB  - BACKGROUND: The present study aimed to assess the efficacy and safety of thoracic 
      paravertebral regional anesthesia (TPVBRA) in patients with breast cancer 
      surgery. METHODS: In total, 72 patients undergoing breast cancer surgery were 
      randomly divided into an intervention group and a control group; each group 
      contained 36 subjects. Both groups received TPVBRA with 20 mL 0.25% bupivacaine. 
      In addition, subjects in the intervention group also received an additional 
      1 mug/kg dexmedetomidine. Heart rate (HR), systolic blood pressure (SBP), 
      diastolic blood pressure (DBP), pain intensity (measured by visual analogue 
      scale, VAS), and analgesic consumption were assessed; adverse events were also 
      recorded. RESULTS: Significant differences were observed in HR (P < .05), SBP 
      (P < .05), and DBP (P < .05) at the 30-minute point during surgery between the 2 
      groups. In addition, the time of the first administration of analgesia (P = .043) 
      and the mean consumption of analgesic agents (P = .035) in the intervention group 
      were much better than those in the control group. However, no significant 
      differences in HR or VAS were found at any time point after surgery (P > .05). 
      Furthermore, similar adverse events were detected in both groups (P > .05). 
      CONCLUSION: The results of this study showed that TPVBRA combined with 
      bupivacaine and dexmedetomidine can enhance the duration and quality of analgesia 
      without serious adverse events.
FAU - Jin, Lian-Jin
AU  - Jin LJ
AD  - Department of Anesthesia Department of Orthopaedics, The Affiliated Hongqi 
      Hospital of Mudanjiang Medical University Department of Anatomy, Mudanjiang 
      Medical University, Mudanjiang, China.
FAU - Wen, Li-Yong
AU  - Wen LY
FAU - Zhang, Yan-Li
AU  - Zhang YL
FAU - Li, Gang
AU  - Li G
FAU - Sun, Ping
AU  - Sun P
FAU - Zhou, Xuan
AU  - Zhou X
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - 0 (Analgesics, Non-Narcotic)
RN  - 0 (Anesthetics, Local)
RN  - 67VB76HONO (Dexmedetomidine)
RN  - Y8335394RO (Bupivacaine)
SB  - IM
MH  - Aged
MH  - Analgesics, Non-Narcotic/*administration & dosage
MH  - Anesthesia, Epidural/*methods
MH  - Anesthetics, Local/*administration & dosage
MH  - Breast Neoplasms/*surgery
MH  - Bupivacaine/administration & dosage
MH  - Dexmedetomidine/administration & dosage
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Pain Measurement
MH  - Pain, Postoperative/drug therapy/*prevention & control
MH  - Thoracic Vertebrae
MH  - Treatment Outcome
PMC - PMC5626274
COIS- The authors report no conflicts of interest.
EDAT- 2017/09/28 06:00
MHDA- 2017/10/06 06:00
PMCR- 2017/09/29
CRDT- 2017/09/28 06:00
PHST- 2017/09/28 06:00 [entrez]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2017/10/06 06:00 [medline]
PHST- 2017/09/29 00:00 [pmc-release]
AID - 00005792-201709290-00024 [pii]
AID - MD-D-17-04449 [pii]
AID - 10.1097/MD.0000000000008107 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2017 Sep;96(39):e8107. doi: 10.1097/MD.0000000000008107.