PMID- 28954271
OWN - NLM
STAT- MEDLINE
DCOM- 20180202
LR  - 20180202
IS  - 1423-0267 (Electronic)
IS  - 0030-3755 (Linking)
VI  - 239
IP  - 1
DP  - 2018
TI  - Impact of Preinjection Spectral Domain Optical Coherence Tomography Findings in 
      the Use of Intravitreal Ocriplasmin in a Clinical Setting.
PG  - 11-18
LID - 10.1159/000480406 [doi]
AB  - PURPOSE: To investigate the impact of spectral domain optical coherence 
      tomography (SD-OCT) morphological predictive markers on visual acuity and outcome 
      using ocriplasmin for macular hole and vitreomacular traction syndrome. METHODS: 
      A series of 40 patients in a retrospective study received intravitreal 
      ocriplasmin. The primary endpoint was defined as morphological resolution of 
      vitreomacular traction or closure of a macular hole. We analyzed the impact of 
      pre- and postinjection SD-OCT findings on the outcome and visual acuity. RESULTS: 
      Thirteen of the 40 patients benefited from treatment. Statistical correlation 
      between baseline characteristics and outcome revealed that higher foveal 
      thickness (p = 0.018) and nontractional epiretinal membranes (p = 0.05) resulted 
      in a worse outcome. In treatment success best corrected visual acuity gained was 
      9 (SD 12) letters and in failure 1 (SD 9) letter. We could not observe an 
      influence of preinjection SD-OCT findings and other factors on visual outcome. 
      CONCLUSION: We could confirm the therapeutic effect of ocriplasmin injections. 
      SD-OCT morphological factors that influence treatment success and visual acuity 
      were determined.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Wertheimer, Christian
AU  - Wertheimer C
AD  - Department of Ophthalmology, Ludwig-Maximilians-University Munich, Munich, 
      Germany.
FAU - Haritoglou, Christos
AU  - Haritoglou C
FAU - Laubichler, Peter
AU  - Laubichler P
FAU - Wolf, Armin
AU  - Wolf A
FAU - Kaessmann, Kathrin
AU  - Kaessmann K
FAU - Schumann, Ricarda G
AU  - Schumann RG
FAU - Priglinger, Siegfried
AU  - Priglinger S
FAU - Mayer, Wolfgang J
AU  - Mayer WJ
LA  - eng
PT  - Journal Article
DEP - 20170928
PL  - Switzerland
TA  - Ophthalmologica
JT  - Ophthalmologica. Journal international d'ophtalmologie. International journal of 
      ophthalmology. Zeitschrift fur Augenheilkunde
JID - 0054655
RN  - 0 (Peptide Fragments)
RN  - 7V6HE3DM5A (microplasmin)
RN  - EC 3.4.21.7 (Fibrinolysin)
SB  - IM
MH  - Aged
MH  - Female
MH  - Fibrinolysin/*administration & dosage
MH  - Follow-Up Studies
MH  - Humans
MH  - Intravitreal Injections
MH  - Longitudinal Studies
MH  - Macula Lutea/drug effects/*pathology
MH  - Male
MH  - Peptide Fragments/*administration & dosage
MH  - Retinal Perforations/diagnosis/*drug therapy
MH  - Retrospective Studies
MH  - Tomography, Optical Coherence/*methods
MH  - Treatment Outcome
MH  - Visual Acuity
MH  - Vitreous Body/drug effects/*pathology
MH  - Vitreous Detachment/diagnosis/*drug therapy
OTO - NOTNLM
OT  - Macular hole
OT  - Medical retina
OT  - Optical coherence tomography
OT  - Pharmacology
OT  - Vitreomacular diseases
EDAT- 2017/09/28 06:00
MHDA- 2018/02/03 06:00
CRDT- 2017/09/28 06:00
PHST- 2017/01/12 00:00 [received]
PHST- 2017/08/14 00:00 [accepted]
PHST- 2017/09/28 06:00 [pubmed]
PHST- 2018/02/03 06:00 [medline]
PHST- 2017/09/28 06:00 [entrez]
AID - 000480406 [pii]
AID - 10.1159/000480406 [doi]
PST - ppublish
SO  - Ophthalmologica. 2018;239(1):11-18. doi: 10.1159/000480406. Epub 2017 Sep 28.