PMID- 28956015
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220331
IS  - 2405-5808 (Print)
IS  - 2405-5808 (Electronic)
IS  - 2405-5808 (Linking)
VI  - 9
DP  - 2017 Mar
TI  - Human umbilical cord blood-derived mesenchymal stem cells ameliorate 
      psoriasis-like skin inflammation in mice.
PG  - 281-288
LID - 10.1016/j.bbrep.2016.10.002 [doi]
AB  - Mesenchymal stem cells (MSCs) inhibit the proliferation or activation of 
      lymphocytes, and their inhibitory effects do not require human leukocyte antigen 
      (HLA)-matching because MSCs express low levels of HLA molecules. Therefore, MSCs 
      may be able to regulate immune responses. In this study, we determined whether 
      MSCs could inhibit psoriasis-like skin inflammation in mice. After induction of 
      psoriasis-like skin inflammation using intradermal injection of IL-23 or topical 
      application of imiquimod with or without treatment with MSC, mouse skins were 
      collected, and H&E staining and real-time PCR were performed. IL-23-induced skin 
      inflammation was inhibited when MSCs were injected on day -1 and day 7. The 
      expression of proinflammatory cytokines such as IL-6, IL-17, and TNF-alpha was 
      inhibited by MSC injection, and the expression of chemokines such as CCL17, 
      CCL20, and CCL27 was also decreased in mouse skin. We also determined whether 
      MSCs could not only prevent but also treat psoriasis-like skin inflammation in 
      mice. Furthermore, in vitro experiments also showed anti-inflammatory effects of 
      MSCs. Dendritic cells which are co-cultured with MSCs suppressed CD4+ T cell 
      activation and differentiation, which are important for the pathogenesis of 
      psoriasis. These results suggest that MSCs could be useful for treating 
      psoriasis.
FAU - Lee, Yun Sang
AU  - Lee YS
AD  - Department of Dermatology, College of Medicine, The Catholic University of Korea, 
      505 Banpo-dong, Seocho-gu, Seoul 137-040, South Korea.
FAU - Sah, Shyam Kishor
AU  - Sah SK
AD  - Department of Dermatology, College of Medicine, The Catholic University of Korea, 
      505 Banpo-dong, Seocho-gu, Seoul 137-040, South Korea.
FAU - Lee, Ji Hyun
AU  - Lee JH
AD  - Department of Dermatology, College of Medicine, The Catholic University of Korea, 
      505 Banpo-dong, Seocho-gu, Seoul 137-040, South Korea.
FAU - Seo, Kwang-Won
AU  - Seo KW
AD  - Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National 
      University, Seoul 151-742, South Korea.
AD  - Institute for Stem Cell and Regenerative Medicine in Kangstem Biotech, 
      Biotechnology Incubating center, Seoul National University, Seoul 151-742, South 
      Korea.
FAU - Kang, Kyung-Sun
AU  - Kang KS
AD  - Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National 
      University, Seoul 151-742, South Korea.
AD  - Researh Institute for Veterinary Medicine, College of Veterinary Medicine, Seoul 
      National University, Seoul 151-742, South Korea.
FAU - Kim, Tae-Yoon
AU  - Kim TY
AD  - Department of Dermatology, College of Medicine, The Catholic University of Korea, 
      505 Banpo-dong, Seocho-gu, Seoul 137-040, South Korea.
LA  - eng
PT  - Journal Article
DEP - 20161008
PL  - Netherlands
TA  - Biochem Biophys Rep
JT  - Biochemistry and biophysics reports
JID - 101660999
PMC - PMC5614481
OTO - NOTNLM
OT  - Anti-inflammatory effects
OT  - BMDC, bone marrow-derived dendritic cell
OT  - IDO, indoleamine 2,3-dioxygenase
OT  - IL, interleukin
OT  - Mesenchymal stem cells
OT  - Psoriasis
OT  - Skin inflammation
OT  - hUCB-MSC, human umbilical cord blood-derived mesenchymal stem cell
EDAT- 2017/09/29 06:00
MHDA- 2017/09/29 06:01
PMCR- 2016/10/08
CRDT- 2017/09/29 06:00
PHST- 2016/06/13 00:00 [received]
PHST- 2016/09/16 00:00 [revised]
PHST- 2016/10/04 00:00 [accepted]
PHST- 2017/09/29 06:00 [entrez]
PHST- 2017/09/29 06:00 [pubmed]
PHST- 2017/09/29 06:01 [medline]
PHST- 2016/10/08 00:00 [pmc-release]
AID - S2405-5808(16)30213-8 [pii]
AID - 10.1016/j.bbrep.2016.10.002 [doi]
PST - epublish
SO  - Biochem Biophys Rep. 2016 Oct 8;9:281-288. doi: 10.1016/j.bbrep.2016.10.002. 
      eCollection 2017 Mar.