PMID- 2895617
OWN - NLM
STAT- MEDLINE
DCOM- 19880429
LR  - 20131121
IS  - 0003-9926 (Print)
IS  - 0003-9926 (Linking)
VI  - 148
IP  - 4
DP  - 1988 Apr
TI  - Clinical evaluation of calcium metabolism in adult T-cell leukemia/lymphoma.
PG  - 921-5
AB  - To clarify the mechanism of development of hypercalcemia in adult T-cell 
      leukemia/lymphoma (ATLL), ten patients with a serum creatinine level less than 
      177 mumol/L (2 mg/dL) were examined. Although hypercalcemia was seen in only four 
      (40%) of these patients, four of six normocalcemic patients showed hypercalciuria 
      (greater than 5 mmol/d [greater than 200 mg/24 h]). All hypercalcemic patients 
      exhibited high nephrogenous cyclic adenosine monophosphate (NcAMP) levels in the 
      face of low-normal immunoreactive parathyroid hormone and reduced serum 
      1,25-dihydroxyvitamin D [1,25(OH)2D] concentration. Half of the hypercalciuric 
      patients with normocalcemia also showed high NcAMP and reduced serum 1,25(OH)2D 
      levels. Furthermore, the changes in NcAMP and serum 1,25(OH)2D concentration 
      closely paralleled the development of hypercalcemia and hypercalciuria in two 
      patients. These results are reminiscent of the syndrome of humoral hypercalcemia 
      of malignancy and suggest that derangements in calcium metabolism develop by a 
      similar mechanism in patients with ATLL. The present data also indicate the 
      importance of the measurement of urinary calcium excretion for early detection 
      and prevention of fatal hypercalcemia in patients with ATLL.
FAU - Fukumoto, S
AU  - Fukumoto S
AD  - Fourth Department of Internal Medicine, University of Tokyo School of Medicine, 
      Japan.
FAU - Matsumoto, T
AU  - Matsumoto T
FAU - Ikeda, K
AU  - Ikeda K
FAU - Yamashita, T
AU  - Yamashita T
FAU - Watanabe, T
AU  - Watanabe T
FAU - Yamaguchi, K
AU  - Yamaguchi K
FAU - Kiyokawa, T
AU  - Kiyokawa T
FAU - Takatsuki, K
AU  - Takatsuki K
FAU - Shibuya, N
AU  - Shibuya N
FAU - Ogata, E
AU  - Ogata E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arch Intern Med
JT  - Archives of internal medicine
JID - 0372440
RN  - 0 (Parathyroid Hormone)
RN  - 1406-16-2 (Vitamin D)
RN  - E0399OZS9N (Cyclic AMP)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium/*blood/urine
MH  - Cyclic AMP/blood
MH  - Deltaretrovirus Infections/*blood/urine
MH  - Female
MH  - Humans
MH  - Hypercalcemia/*blood/urine
MH  - Male
MH  - Middle Aged
MH  - Parathyroid Hormone/blood
MH  - Vitamin D/blood
EDAT- 1988/04/01 00:00
MHDA- 1988/04/01 00:01
CRDT- 1988/04/01 00:00
PHST- 1988/04/01 00:00 [pubmed]
PHST- 1988/04/01 00:01 [medline]
PHST- 1988/04/01 00:00 [entrez]
PST - ppublish
SO  - Arch Intern Med. 1988 Apr;148(4):921-5.