PMID- 28956368
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20191120
IS  - 2093-596X (Print)
IS  - 2093-5978 (Electronic)
IS  - 2093-596X (Linking)
VI  - 32
IP  - 3
DP  - 2017 Sep
TI  - A Novel Index Using Soluble CD36 Is Associated with the Prevalence of Type 2 
      Diabetes Mellitus: Comparison Study with Triglyceride-Glucose Index.
PG  - 375-382
LID - 10.3803/EnM.2017.32.3.375 [doi]
AB  - BACKGROUND: Plasma soluble cluster determinant 36 (sCD36) level is closely 
      related with insulin resistance and atherosclerosis, but little is known whether 
      it could be a surrogate for estimating risk of developing diabetes or not. To 
      address this, we evaluated association between sCD36 index, the product of sCD36 
      and fasting plasma glucose (FPG), and the prevalence of type 2 diabetes mellitus 
      (T2DM), and then compared with triglyceride-glucose (TyG) index which has been 
      suggested simple index for insulin resistance. METHODS: This was cross-sectional 
      study, and participants were classified as normal glucose tolerance (NGT), 
      prediabetes, and T2DM according to glucose tolerance. The formula of TyG index 
      was 'ln [FPG (mg/dL)xtriglyceride (mg/dL)/2],' and the sCD36 index was 'ln [sCD36 
      (pg/mL)xFPG (mg/dL)/2].' RESULTS: One hundred and fifty-five subjects (mean age, 
      55.2 years) were enrolled, and patients with T2DM were 75. Both indexes were 
      significantly increased in prediabetes and T2DM rather than NGT, and sCD36 index 
      was positively correlated with both glycosylated hemoglobin and homeostasis model 
      assessment of insulin resistance (r=0.767 and r=0.453, respectively; P<0.05) and 
      negatively with homeostasis model assessment estimate of beta-cell function 
      (r=-0.317). The odds ratio (OR) of sCD36 index for T2DM was 4.39 (95% 
      confidential interval, 1.51 to 12.77) after adjusting age, gender, blood 
      pressure, smoking, alcohol, non-high density lipoprotein cholesterol and 
      high-sensitivity C-reactive protein. However, OR of TyG index did not remained 
      significance after adjustment. CONCLUSION: sCD36 index has an independent 
      association with the risk of T2DM, and showed better correlation than TyG index. 
      These results suggest sCD36 index might be useful surrogate marker for the risk 
      of diabetes.
CI  - Copyright (c) 2017 Korean Endocrine Society
FAU - Kim, Ho Jin
AU  - Kim HJ
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Moon, Jun Sung
AU  - Moon JS
AUID- ORCID: 0000-0003-1569-3068
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Park, Il Rae
AU  - Park IR
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Kim, Joong Hee
AU  - Kim JH
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Yoon, Ji Sung
AU  - Yoon JS
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Won, Kyu Chang
AU  - Won KC
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea.
FAU - Lee, Hyoung Woo
AU  - Lee HW
AD  - Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, 
      Korea. helee@ynu.ac.kr.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Endocrinol Metab (Seoul)
JT  - Endocrinology and metabolism (Seoul, Korea)
JID - 101554139
PMC - PMC5620035
OTO - NOTNLM
OT  - CD36
OT  - CD36 index
OT  - Diabetes mellitus, type 2
OT  - Insulin resistance
OT  - TyG index
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2017/09/29 06:00
MHDA- 2017/09/29 06:01
PMCR- 2017/09/01
CRDT- 2017/09/29 06:00
PHST- 2017/04/25 00:00 [received]
PHST- 2017/07/05 00:00 [revised]
PHST- 2017/07/06 00:00 [accepted]
PHST- 2017/09/29 06:00 [entrez]
PHST- 2017/09/29 06:00 [pubmed]
PHST- 2017/09/29 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 32.375 [pii]
AID - 10.3803/EnM.2017.32.3.375 [doi]
PST - ppublish
SO  - Endocrinol Metab (Seoul). 2017 Sep;32(3):375-382. doi: 10.3803/EnM.2017.32.3.375.