PMID- 28957666
OWN - NLM
STAT- MEDLINE
DCOM- 20171010
LR  - 20220410
IS  - 1097-4199 (Electronic)
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 96
IP  - 1
DP  - 2017 Sep 27
TI  - The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in 
      Health and Disease.
PG  - 17-42
LID - S0896-6273(17)30652-9 [pii]
LID - 10.1016/j.neuron.2017.07.030 [doi]
AB  - The concept of the neurovascular unit (NVU), formalized at the 2001 Stroke 
      Progress Review Group meeting of the National Institute of Neurological Disorders 
      and Stroke, emphasizes the intimate relationship between the brain and its 
      vessels. Since then, the NVU has attracted the interest of the neuroscience 
      community, resulting in considerable advances in the field. Here the current 
      state of knowledge of the NVU will be assessed, focusing on one of its most vital 
      roles: the coupling between neural activity and blood flow. The evidence supports 
      a conceptual shift in the mechanisms of neurovascular coupling, from a 
      unidimensional process involving neuronal-astrocytic signaling to local blood 
      vessels to a multidimensional one in which mediators released from multiple cells 
      engage distinct signaling pathways and effector systems across the entire 
      cerebrovascular network in a highly orchestrated manner. The recently appreciated 
      NVU dysfunction in neurodegenerative diseases, although still poorly understood, 
      supports emerging concepts that maintaining neurovascular health promotes brain 
      health.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Iadecola, Costantino
AU  - Iadecola C
AD  - Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, 
      NY 10065, USA. Electronic address: coi2001@med.cornell.edu.
LA  - eng
GR  - R01 NS037853/NS/NINDS NIH HHS/United States
GR  - R01 NS100447/NS/NINDS NIH HHS/United States
GR  - R01 NS034179/NS/NINDS NIH HHS/United States
GR  - R01 NS095441/NS/NINDS NIH HHS/United States
GR  - R37 NS089323/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
SB  - IM
MH  - Astrocytes/physiology
MH  - Brain/*blood supply
MH  - *Health
MH  - Humans
MH  - Models, Neurological
MH  - Neurodegenerative Diseases/*physiopathology
MH  - Neurons/physiology
MH  - Neurovascular Coupling/*physiology
MH  - Signal Transduction/physiology
PMC - PMC5657612
MID - NIHMS895921
OTO - NOTNLM
OT  - astrocytes
OT  - cerebral blood flow
OT  - endothelium
OT  - functional hyperemia
OT  - neurodegeneration
OT  - neuroimaging
OT  - pericytes
OT  - smooth muscle cells
EDAT- 2017/09/29 06:00
MHDA- 2017/10/11 06:00
PMCR- 2018/09/27
CRDT- 2017/09/29 06:00
PHST- 2017/06/16 00:00 [received]
PHST- 2017/07/20 00:00 [revised]
PHST- 2017/07/25 00:00 [accepted]
PHST- 2017/09/29 06:00 [entrez]
PHST- 2017/09/29 06:00 [pubmed]
PHST- 2017/10/11 06:00 [medline]
PHST- 2018/09/27 00:00 [pmc-release]
AID - S0896-6273(17)30652-9 [pii]
AID - 10.1016/j.neuron.2017.07.030 [doi]
PST - ppublish
SO  - Neuron. 2017 Sep 27;96(1):17-42. doi: 10.1016/j.neuron.2017.07.030.