PMID- 28958142
OWN - NLM
STAT- MEDLINE
DCOM- 20171214
LR  - 20180813
IS  - 0393-974X (Print)
IS  - 0393-974X (Linking)
VI  - 31
IP  - 3
DP  - 2017 Jul-Sep
TI  - Serum 25-hydroxy vitamin D concentration in acute coronary syndrome.
PG  - 823-827
LID - 40 [pii]
AB  - Vitamin D may have prognostic value in cardiovascular disease (CVD) patients and, 
      in addition to conventional biomarkers, could be a valuable tool for disease 
      management. The aim of this study was to assess the association of vitamin D 
      status in patients with acute coronary syndrome (ACS) and to evaluate its 
      prognostic utility. The levels of 25(OH) vitamin D were correlated with troponin 
      T hs. Forty-eight consecutive outpatients (40 Caucasian and 8 Asian) aged between 
      40 and 70 years (mean 61.5, range 43-77 years) were enrolled in the study. All 
      patients were admitted to the Emergency Department with chest pain and suspected 
      ACS. The main exclusion criteria were age <18 years, kidney failure, 
      onco-haematological disease, hypo-hyperparathyroidism, hypo/hyperthyroidism, 
      osteoporosis, treatment with bisphosphonate or 25(OH) vitamin D supplementation. 
      Of the 48 subjects included in the study, thoracic pain symptoms were described 
      in 12 patients with unstable angina (UA) and in 6 patients with ST elevation 
      myocardial infarction (STEMI) and in 30 patients with non-ST-elevation myocardial 
      infarction (NSTEMI). Low 25(OH) vitamin D levels correlated with the presence of 
      ACS (p< 0.02) and inversely correlated with Troponin T hs (TnT hs) levels (p< 
      0.03). The determination of 25(OH) vitamin D levels in combination with TnT hs 
      could improve the research for possible underlying conditions, and these should 
      be managed meticulously according to current guidelines.
FAU - Anastasi, E
AU  - Anastasi E
AD  - Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy
FAU - Suppa, M
AU  - Suppa M
AD  - Emergency Department, "Sapienza" University of Rome, Rome, Italy-Policlinico 
      Umberto I, Rome, Italy
FAU - Viggiani, V
AU  - Viggiani V
AD  - Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy
FAU - Tartaglione, S
AU  - Tartaglione S
AD  - Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy
FAU - Angeloni, A
AU  - Angeloni A
AD  - Department of Molecular Medicine, "Sapienza" University of Rome, Rome, Italy
FAU - Granato, T
AU  - Granato T
AD  - CNR-IBPM, National Research Council, Rome, Italy
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PL  - Italy
TA  - J Biol Regul Homeost Agents
JT  - Journal of biological regulators and homeostatic agents
JID - 8809253
RN  - 0 (Troponin T)
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Acute Coronary Syndrome/*blood
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/*blood
MH  - Troponin T/blood
MH  - Vitamin D/*analogs & derivatives/blood
EDAT- 2017/09/30 06:00
MHDA- 2017/12/15 06:00
CRDT- 2017/09/30 06:00
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2017/12/15 06:00 [medline]
PHST- 2017/09/30 06:00 [entrez]
AID - 40 [pii]
PST - ppublish
SO  - J Biol Regul Homeost Agents. 2017 Jul-Sep;31(3):823-827.