PMID- 28958795
OWN - NLM
STAT- MEDLINE
DCOM- 20180327
LR  - 20180327
IS  - 1875-0834 (Electronic)
IS  - 1760-2734 (Linking)
VI  - 19
IP  - 5
DP  - 2017 Oct
TI  - Heart rate turbulence after ventricular premature beats in healthy Doberman 
      pinschers and those with dilated cardiomyopathy.
PG  - 421-432
LID - S1760-2734(16)30086-8 [pii]
LID - 10.1016/j.jvc.2017.08.005 [doi]
AB  - OBJECTIVES: To describe the measurement of heart rate turbulence (HRT) after 
      ventricular premature beats and compare HRT in healthy Doberman pinschers and 
      those with dilated cardiomyopathy (DCM), with and without congestive heart 
      failure (CHF). ANIMALS: Sixty-five client-owned Dobermans: 20 healthy (NORMAL), 
      31 with preclinical DCM and 14 with DCM and CHF (DCM + CHF). METHODS: A 
      retrospective study of data retrieved from clinical records and ambulatory ECG 
      (Holter) archives, including data collected previously for a large-scale 
      prospective study of Dobermans with preclinical DCM. Holter data were reanalysed 
      quantitatively, including conventional time-domain heart rate variability and the 
      HRT parameters turbulence onset and turbulence slope. RESULTS: Heart rate 
      turbulence could be measured in 58/65 dogs. Six Holter recordings had inadequate 
      ventricular premature contractions (VPCs) and one exhibited VPCs too similar to 
      sinus morphology. Heart rate turbulence parameter, turbulence onset, was 
      significantly reduced in DCM dogs, whereas conventional heart rate variability 
      measures were not. Heart rate variability and HRT markers were reduced in 
      DCM + CHF dogs as expected. CONCLUSIONS: Heart rate turbulence can be measured 
      from the majority of good quality standard canine 24-hour Holter recordings with 
      >5 VPCs. Turbulence onset is significantly reduced in Dobermans with preclinical 
      DCM which indicates vagal withdrawal early in the course of disease. Heart rate 
      turbulence is a powerful prognostic indicator in human cardiac disease which can 
      be measured from standard 24-hour ambulatory ECG (Holter) recordings using 
      appropriate computer software. Further studies are warranted to assess whether 
      HRT may be of prognostic value in dogs with preclinical DCM and in other canine 
      cardiac disease.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Harris, J D
AU  - Harris JD
AD  - HeartVets, The Animal Hospital, Stinchcombe, Dursley, Gloucestershire, GL11 6AJ, 
      UK. Electronic address: jo@heartvets.co.uk.
FAU - Little, C J L
AU  - Little CJL
AD  - Barton Veterinary Hospital, 34 New Dover Road, Canterbury, Kent, CT1 3BH, UK.
FAU - Dennis, J M
AU  - Dennis JM
AD  - Health Statistics Group, Institute of Health Research, University of Exeter 
      Medical School, Exeter, EX1 2LU, UK.
FAU - Patteson, M W
AU  - Patteson MW
AD  - HeartVets, The Animal Hospital, Stinchcombe, Dursley, Gloucestershire, GL11 6AJ, 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20170925
PL  - Netherlands
TA  - J Vet Cardiol
JT  - Journal of veterinary cardiology : the official journal of the European Society 
      of Veterinary Cardiology
JID - 101163270
SB  - IM
MH  - Animals
MH  - Cardiomyopathy, Dilated/diagnosis/physiopathology/*veterinary
MH  - Case-Control Studies
MH  - Dog Diseases/diagnosis/*physiopathology
MH  - Dogs
MH  - Electrocardiography, Ambulatory/veterinary
MH  - Female
MH  - Heart Rate
MH  - Male
MH  - Pedigree
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Ventricular Premature Complexes/diagnosis/physiopathology/*veterinary
OTO - NOTNLM
OT  - Autonomic nervous system
OT  - Canine
OT  - Congestive heart failure
OT  - Heart rate variability
OT  - Holter monitoring
EDAT- 2017/09/30 06:00
MHDA- 2018/03/28 06:00
CRDT- 2017/09/30 06:00
PHST- 2016/10/04 00:00 [received]
PHST- 2017/07/31 00:00 [revised]
PHST- 2017/08/08 00:00 [accepted]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2018/03/28 06:00 [medline]
PHST- 2017/09/30 06:00 [entrez]
AID - S1760-2734(16)30086-8 [pii]
AID - 10.1016/j.jvc.2017.08.005 [doi]
PST - ppublish
SO  - J Vet Cardiol. 2017 Oct;19(5):421-432. doi: 10.1016/j.jvc.2017.08.005. Epub 2017 
      Sep 25.