PMID- 28958804
OWN - NLM
STAT- MEDLINE
DCOM- 20171218
LR  - 20180207
IS  - 1873-2933 (Electronic)
IS  - 0009-9120 (Linking)
VI  - 50
IP  - 18
DP  - 2017 Dec
TI  - Effect of a low glycemic index diet versus a high-cereal fibre diet on markers of 
      subclinical cardiac injury in healthy individuals with type 2 diabetes mellitus: 
      An exploratory analysis of a randomized dietary trial.
PG  - 1104-1109
LID - S0009-9120(17)30639-2 [pii]
LID - 10.1016/j.clinbiochem.2017.09.021 [doi]
AB  - BACKGROUND: Markers of subclinical cardiac injury are elevated in individuals 
      with type 2 diabetes mellitus (T2DM) compared to healthy individuals. Low 
      glycemic index (LGI) diets may improve both diabetes and cardiovascular risk but 
      their effects on cardiac injury and fibrosis have not been previously studied. To 
      test the effect of a LGI diet on markers of subclinical cardiac injury and 
      fibrosis, we assessed the effect of a LGI compared with a high-cereal fibre diet 
      on high-sensitivity cardiac troponin I (hs-cTnI) and galectin-3 in otherwise 
      healthy individuals with T2DM in an exploratory analysis of a completed 
      randomized trial. METHODS: A total of 201 participants completed the trial and 
      had measurements of hs-cTnI and galectin-3 at baseline and at trial completion. 
      Participants were randomized to follow a LGI or a high-cereal fibre diet over a 
      6-month period. Treatment differences were tested using Analysis of Covariance 
      (ANCOVA) with sex, baseline values, and diet x sex interaction included as 
      covariates. RESULTS: In a completer's analysis, no significant differences were 
      observed for change in hs-cTnI (-0.16ng/L vs. -0.22ng/L, p=0.713) and galectin-3 
      levels (0.64mug/L vs. 0.14mug/L, p=0.166) when a LGI diet was compared to a 
      high-cereal fibre diet. CONCLUSIONS: The effect of a LGI diet was similar to a 
      high-cereal fibre diet on hs-cTnI and galectin-3 levels in otherwise healthy 
      individuals with T2DM over a 6-month period. Nevertheless, in the absence of any 
      adverse effects, LGI diets remain an option for diabetes and cardiovascular 
      disease risk management. ClinicalTrials.gov identifier: NCT00438698.
CI  - Copyright (c) 2017 The Canadian Society of Clinical Chemists. Published by Elsevier 
      Inc. All rights reserved.
FAU - Ha, Vanessa
AU  - Ha V
AD  - Department of Health Research Methods, Evidence, and Impact, McMaster University, 
      Hamilton, Ontario, Canada; Clinical Nutrition and Risk Factor Modification 
      Centre, St. Michael's Hospital, Toronto, Ontario, Canada.
FAU - Viguiliouk, Effie
AU  - Viguiliouk E
AD  - Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, 
      Toronto, Ontario, Canada.
FAU - Kendall, Cyril W C
AU  - Kendall CWC
AD  - Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, 
      Toronto, Ontario, Canada; Department of Nutritional Sciences, Faculty of 
      Medicine, University of Toronto, Toronto, Ontario, Canada; College of Pharmacy 
      and Nutrition, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
FAU - Balachandran, Bashyam
AU  - Balachandran B
AD  - Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, 
      Toronto, Ontario, Canada; Department of Nutritional Sciences, Faculty of 
      Medicine, University of Toronto, Toronto, Ontario, Canada.
FAU - Jenkins, David J A
AU  - Jenkins DJA
AD  - Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, 
      Toronto, Ontario, Canada; Department of Nutritional Sciences, Faculty of 
      Medicine, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge 
      Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Division of 
      Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada.
FAU - Kavsak, Peter A
AU  - Kavsak PA
AD  - Department of Pathology and Molecular Medicine, McMaster University, Hamilton, 
      Ontario, Canada.
FAU - Sievenpiper, John L
AU  - Sievenpiper JL
AD  - Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital, 
      Toronto, Ontario, Canada; Department of Nutritional Sciences, Faculty of 
      Medicine, University of Toronto, Toronto, Ontario, Canada; Li Ka Shing Knowledge 
      Institute, St. Michael's Hospital, Toronto, Ontario, Canada; Division of 
      Endocrinology and Metabolism, St. Michael's Hospital, Toronto, Ontario, Canada. 
      Electronic address: john.sievenpiper@utoronto.ca.
LA  - eng
SI  - ClinicalTrials.gov/NCT00438698
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170925
PL  - United States
TA  - Clin Biochem
JT  - Clinical biochemistry
JID - 0133660
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fiber)
RN  - 0 (Galectin 3)
RN  - 0 (Troponin I)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Diseases/blood/*diet therapy
MH  - Diabetes Mellitus, Type 2/complications/*diet therapy
MH  - Diet
MH  - Dietary Fiber/*administration & dosage
MH  - Feeding Behavior
MH  - Female
MH  - Galectin 3/blood/metabolism
MH  - Glycemic Index
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Troponin I/blood/metabolism
OTO - NOTNLM
OT  - Cardiac injury
OT  - Cardiovascular disease
OT  - Diabetes
OT  - Galectin-3
OT  - High-cereal fibre
OT  - Low glycemic index
OT  - Troponins
EDAT- 2017/09/30 06:00
MHDA- 2017/12/19 06:00
CRDT- 2017/09/30 06:00
PHST- 2017/06/28 00:00 [received]
PHST- 2017/09/22 00:00 [revised]
PHST- 2017/09/22 00:00 [accepted]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2017/12/19 06:00 [medline]
PHST- 2017/09/30 06:00 [entrez]
AID - S0009-9120(17)30639-2 [pii]
AID - 10.1016/j.clinbiochem.2017.09.021 [doi]
PST - ppublish
SO  - Clin Biochem. 2017 Dec;50(18):1104-1109. doi: 10.1016/j.clinbiochem.2017.09.021. 
      Epub 2017 Sep 25.