PMID- 28959103
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 1011-6842 (Print)
IS  - 1011-6842 (Linking)
VI  - 33
IP  - 5
DP  - 2017 Sep
TI  - Long-Term Survival of Patients with Pulmonary Arterial Hypertension at a Single 
      Center in Taiwan.
PG  - 498-509
AB  - BACKGROUND: Clinical studies have suggested predictive parameters in mortality 
      risk assessment for pulmonary arterial hypertension (PAH) patients. However, 
      these studies predominantly include Caucasian population; information in Asian 
      population is relatively deficient. In this study, we investigated the long-term 
      survival of PAH patients and the predictors of mortality in our population. 
      METHODS: We prospectively collected 70 patients with PAH at the Chang Gung 
      Memorial Hospital between March 2002 and February 2015. Baseline data including 
      functional class (FC), 6-minute walk distance (6MWD), hematological and 
      biochemical data, echocardiography and cardiac catheterization were obtained 
      before commencing PAH- targeted treatment. The follow-up period for analyses of 
      survivors ended in October 2015. RESULTS: The mean age at diagnosis was 40.7 +/- 
      15.2 years. Mean follow-up period was 4.6 +/- 3.4 years, with 1-, 2-, 3-, and 
      5-year survival rates of 93%, 88%, 84%, and 77%, respectively. The baseline FC 
      was worse in non-survivors than in survivors. More frequent presence of 
      pericardial effusion, higher serum glucose levels, higher estimated systolic 
      pulmonary artery pressure (SPAP) by echocardiography, and higher right atrial 
      pressure (RAP) were found in non-survivors. Higher FC, lower 6MWD, and presence 
      of pericardial effusion were associated with risk of mortality. Patients with 
      worsening FC and increased serum uric acid had an increased risk of mortality 
      during follow-up. CONCLUSIONS: The overall survival remained unsatisfactory in 
      PAH patients. Baseline FC, 6MWD, pericardial effusion, RAP, and a worsening FC 
      and an increased serum uric acid levels during follow-up were significant 
      prognostic parameters.
FAU - Wang, Le-Yung
AU  - Wang LY
AD  - College of Medicine, Chang Gung University, Chang Gung Memorial Hospital.
FAU - Lee, Kuang-Tso
AU  - Lee KT
AD  - Department of Cardiology, Chang Gung Memorial Hospital, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
FAU - Lin, Chia-Pin
AU  - Lin CP
AD  - Department of Cardiology, Chang Gung Memorial Hospital, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
FAU - Hsu, Lung-An
AU  - Hsu LA
AD  - Department of Cardiology, Chang Gung Memorial Hospital, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
FAU - Wang, Chun-Li
AU  - Wang CL
AD  - Department of Cardiology, Chang Gung Memorial Hospital, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
FAU - Hsu, Tsu-Shiu
AU  - Hsu TS
AD  - Department of Cardiology, Chang Gung Memorial Hospital, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
FAU - Ho, Wan-Jing
AU  - Ho WJ
AD  - Department of Cardiology, Chang Gung Memorial Hospital, College of Medicine, 
      Chang Gung University, Taoyuan, Taiwan.
LA  - eng
PT  - Journal Article
PL  - China (Republic : 1949- )
TA  - Acta Cardiol Sin
JT  - Acta Cardiologica Sinica
JID - 101687085
PMC - PMC5611347
OTO - NOTNLM
OT  - Functional class
OT  - Pericardial effusion
OT  - Pulmonary arterial hypertension
OT  - Serum glucose
OT  - Uric acid
EDAT- 2017/09/30 06:00
MHDA- 2017/09/30 06:01
PMCR- 2017/09/01
CRDT- 2017/09/30 06:00
PHST- 2017/09/30 06:00 [entrez]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2017/09/30 06:01 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - 10.6515/acs20170612a [doi]
PST - ppublish
SO  - Acta Cardiol Sin. 2017 Sep;33(5):498-509. doi: 10.6515/acs20170612a.