PMID- 28959190
OWN - NLM
STAT- MEDLINE
DCOM- 20180523
LR  - 20181113
IS  - 1662-5110 (Electronic)
IS  - 1662-5110 (Linking)
VI  - 11
DP  - 2017
TI  - Cellular and Molecular Mechanisms of REM Sleep Homeostatic Drive: A Plausible 
      Component for Behavioral Plasticity.
PG  - 63
LID - 10.3389/fncir.2017.00063 [doi]
LID - 63
AB  - Homeostatic regulation of REM sleep drive, as measured by an increase in the 
      number of REM sleep transitions, plays a key role in neuronal and behavioral 
      plasticity (i.e., learning and memory). Deficits in REM sleep homeostatic drive 
      (RSHD) are implicated in the development of many neuropsychiatric disorders. Yet, 
      the cellular and molecular mechanisms underlying this RSHD remain to be 
      incomplete. To further our understanding of this mechanism, the current study was 
      performed on freely moving rats to test a hypothesis that a positive interaction 
      between extracellular-signal-regulated kinase 1 and 2 (ERK1/2) activity and 
      brain-derived neurotrophic factor (BDNF) signaling in the pedunculopontine 
      tegmentum (PPT) is a causal factor for the development of RSHD. Behavioral 
      results of this study demonstrated that a short period (<90 min) of selective REM 
      sleep restriction (RSR) exhibited a strong RSHD. Molecular analyses revealed that 
      this increased RSHD increased phosphorylation and activation of ERK1/2 and BDNF 
      expression in the PPT. Additionally, pharmacological results demonstrated that 
      the application of the ERK1/2 activation inhibitor U0126 into the PPT prevented 
      RSHD and suppressed BDNF expression in the PPT. These results, for the first 
      time, suggest that the positive interaction between ERK1/2 and BDNF in the PPT is 
      a casual factor for the development of RSHD. These findings provide a novel 
      direction in understanding how RSHD-associated specific molecular changes can 
      facilitate neuronal plasticity and memory processing.
FAU - Datta, Subimal
AU  - Datta S
AD  - Laboratory of Sleep and Cognitive Neuroscience, Graduate School of Medicine, 
      Department of Anesthesiology, The University of TennesseeKnoxville, TN, United 
      States.
AD  - Department of Psychology, College of Arts and Sciences, The University of 
      TennesseeKnoxville, TN, United States.
FAU - Oliver, Michael D
AU  - Oliver MD
AD  - Laboratory of Sleep and Cognitive Neuroscience, Graduate School of Medicine, 
      Department of Anesthesiology, The University of TennesseeKnoxville, TN, United 
      States.
AD  - Department of Psychology, College of Arts and Sciences, The University of 
      TennesseeKnoxville, TN, United States.
LA  - eng
GR  - R01 MH059839/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170914
PL  - Switzerland
TA  - Front Neural Circuits
JT  - Frontiers in neural circuits
JID - 101477940
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Butadienes)
RN  - 0 (Enzyme Inhibitors)
RN  - 0 (Myelin Basic Protein)
RN  - 0 (Nitriles)
RN  - 0 (U 0126)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Butadienes/pharmacology
MH  - Dose-Response Relationship, Drug
MH  - Electroencephalography
MH  - Electromyography
MH  - Enzyme Inhibitors/pharmacology
MH  - Gene Expression Regulation/drug effects
MH  - Homeostasis/drug effects/*physiology
MH  - MAP Kinase Signaling System/drug effects/physiology
MH  - Male
MH  - Microinjections
MH  - Mitogen-Activated Protein Kinase 3/metabolism
MH  - Myelin Basic Protein/metabolism
MH  - Nitriles/pharmacology
MH  - Phosphorylation/drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Sleep, REM/drug effects/*physiology
MH  - Tegmentum Mesencephali/drug effects/*physiology
MH  - Wakefulness
PMC - PMC5603703
OTO - NOTNLM
OT  - U0126
OT  - brainstem
OT  - intracellular signaling
OT  - rat
OT  - selective REM sleep restriction
EDAT- 2017/09/30 06:00
MHDA- 2018/05/24 06:00
PMCR- 2017/01/01
CRDT- 2017/09/30 06:00
PHST- 2017/03/09 00:00 [received]
PHST- 2017/08/29 00:00 [accepted]
PHST- 2017/09/30 06:00 [entrez]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2018/05/24 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fncir.2017.00063 [doi]
PST - epublish
SO  - Front Neural Circuits. 2017 Sep 14;11:63. doi: 10.3389/fncir.2017.00063. 
      eCollection 2017.