PMID- 28959191
OWN - NLM
STAT- MEDLINE
DCOM- 20180523
LR  - 20181113
IS  - 1662-5110 (Electronic)
IS  - 1662-5110 (Linking)
VI  - 11
DP  - 2017
TI  - Distinct Temporal Coordination of Spontaneous Population Activity between Basal 
      Forebrain and Auditory Cortex.
PG  - 64
LID - 10.3389/fncir.2017.00064 [doi]
LID - 64
AB  - The basal forebrain (BF) has long been implicated in attention, learning and 
      memory, and recent studies have established a causal relationship between 
      artificial BF activation and arousal. However, neural ensemble dynamics in the BF 
      still remains unclear. Here, recording neural population activity in the BF and 
      comparing it with simultaneously recorded cortical population under both 
      anesthetized and unanesthetized conditions, we investigate the difference in the 
      structure of spontaneous population activity between the BF and the auditory 
      cortex (AC) in mice. The AC neuronal population show a skewed spike rate 
      distribution, a higher proportion of short (</=80 ms) inter-spike intervals (ISIs) 
      and a rich repertoire of rhythmic firing across frequencies. Although the 
      distribution of spontaneous firing rate in the BF is also skewed, a proportion of 
      short ISIs can be explained by a Poisson model at short time scales (</=20 ms) and 
      spike count correlations are lower compared to AC cells, with optogenetically 
      identified cholinergic cell pairs showing exceptionally higher correlations. 
      Furthermore, a smaller fraction of BF neurons shows spike-field entrainment 
      across frequencies: a subset of BF neurons fire rhythmically at slow (</=6 Hz) 
      frequencies, with varied phase preferences to ongoing field potentials, in 
      contrast to a consistent phase preference of AC populations. Firing of these slow 
      rhythmic BF cells is correlated to a greater degree than other rhythmic BF cell 
      pairs. Overall, the fundamental difference in the structure of population 
      activity between the AC and BF is their temporal coordination, in particular 
      their operational timescales. These results suggest that BF neurons slowly 
      modulate downstream populations whereas cortical circuits transmit signals on 
      multiple timescales. Thus, the characterization of the neural ensemble dynamics 
      in the BF provides further insight into the neural mechanisms, by which brain 
      states are regulated.
FAU - Yague, Josue G
AU  - Yague JG
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of 
      StrathclydeGlasgow, United Kingdom.
FAU - Tsunematsu, Tomomi
AU  - Tsunematsu T
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of 
      StrathclydeGlasgow, United Kingdom.
FAU - Sakata, Shuzo
AU  - Sakata S
AD  - Strathclyde Institute of Pharmacy and Biomedical Sciences, University of 
      StrathclydeGlasgow, United Kingdom.
LA  - eng
GR  - BB/K016830/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
GR  - BB/M00905X/1/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170914
PL  - Switzerland
TA  - Front Neural Circuits
JT  - Frontiers in neural circuits
JID - 101477940
RN  - 0 (Channelrhodopsins)
RN  - 0 (Parvalbumins)
RN  - EC 2.3.1.6 (Choline O-Acetyltransferase)
SB  - IM
MH  - Action Potentials/*physiology
MH  - Animals
MH  - Auditory Cortex/cytology/*physiology
MH  - Basal Forebrain/cytology/*physiology
MH  - Channelrhodopsins/genetics/metabolism
MH  - Choline O-Acetyltransferase/genetics/metabolism
MH  - Electroencephalography
MH  - Female
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Nerve Net/*physiology
MH  - Neurons/*physiology
MH  - Optogenetics
MH  - Parvalbumins/genetics/metabolism
PMC - PMC5603709
OTO - NOTNLM
OT  - acetylcholine
OT  - brain state
OT  - neural coding
OT  - neural ensemble
OT  - neural oscillations
OT  - optogenetics
EDAT- 2017/09/30 06:00
MHDA- 2018/05/24 06:00
PMCR- 2017/01/01
CRDT- 2017/09/30 06:00
PHST- 2017/05/01 00:00 [received]
PHST- 2017/08/31 00:00 [accepted]
PHST- 2017/09/30 06:00 [entrez]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2018/05/24 06:00 [medline]
PHST- 2017/01/01 00:00 [pmc-release]
AID - 10.3389/fncir.2017.00064 [doi]
PST - epublish
SO  - Front Neural Circuits. 2017 Sep 14;11:64. doi: 10.3389/fncir.2017.00064. 
      eCollection 2017.