PMID- 28959670
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 2214-7500 (Print)
IS  - 2214-7500 (Electronic)
IS  - 2214-7500 (Linking)
VI  - 4
DP  - 2017
TI  - Is Andrographis paniculata extract and andrographolide anaphylactic?
PG  - 431-437
LID - 10.1016/j.toxrep.2017.07.004 [doi]
AB  - Andrographis paniculata, "King of bitters" is a popularly known medicinal plant 
      extensively used in many parts of the world for treatment of various diseases. 
      Since recent past, anaphylactic/allergic type adverse events were reported upon 
      A. paniculata usage, the study aimed to evaluate the anaphylactic and 
      anaphylactoid potential of A. paniculata extract and andrographolide (a major 
      phytoactive of A. paniculata). The anaphylactic potential was evaluated using 
      active systemic anaphylaxis (ASA) assay in guinea pigs. Further, the release of 
      allergic mediators was measured in immunoglobulin E (IgE) sensitized and non-IgE 
      sensitized Rat Basophilic Leukemia (RBL-2H3) cell lines in-vitro. A. paniculata 
      extract or andrographolide sensitized guinea pigs following the challenge antigen 
      administration orally and intravenously did not demonstrate any clinical signs of 
      anaphylaxis. IgE sensitized and non- IgE sensitized RBL-2H3 cells treated with A. 
      paniculata extract did not induce release of allergic mediators. Whereas IgE 
      sensitized and non- IgE sensitized RBL-2H3 cells treated with andrographolide 
      demonstrated mild to moderate release of allergic mediators. A. paniculata 
      extract has no anaphylactic and anaphylactoid potential in in-vivo and in-vitro 
      studies. Whereas, andrographolide effects on allergic mediators in in-vitro 
      studies needs to be scrutinized if they are of biologically important.
FAU - Richard, Edwin Jothie
AU  - Richard EJ
AD  - Department of Biology, R&D Centre, Natural Remedies Private Limited, Bangalore, 
      560 100, Karnataka, India.
FAU - Murugan, Sasikumar
AU  - Murugan S
AD  - Department of Biology, R&D Centre, Natural Remedies Private Limited, Bangalore, 
      560 100, Karnataka, India.
FAU - Bethapudi, Bharathi
AU  - Bethapudi B
AD  - Department of Biology, R&D Centre, Natural Remedies Private Limited, Bangalore, 
      560 100, Karnataka, India.
FAU - Illuri, Ramanaiah
AU  - Illuri R
AD  - Department of Biology, R&D Centre, Natural Remedies Private Limited, Bangalore, 
      560 100, Karnataka, India.
FAU - Mundkinajeddu, Deepak
AU  - Mundkinajeddu D
AD  - Department of Biology, R&D Centre, Natural Remedies Private Limited, Bangalore, 
      560 100, Karnataka, India.
FAU - Chinampudur Velusami, Chandrasekaran
AU  - Chinampudur Velusami C
AD  - Department of Biology, R&D Centre, Natural Remedies Private Limited, Bangalore, 
      560 100, Karnataka, India.
LA  - eng
PT  - Journal Article
DEP - 20170729
PL  - Ireland
TA  - Toxicol Rep
JT  - Toxicology reports
JID - 101630272
PMC - PMC5615142
OTO - NOTNLM
OT  - &beta
OT  - &minus
OT  - Active systemic anaphylaxis
OT  - Anaphylactoid
OT  - Andrographis paniculata extract
OT  - Andrographolide
OT  - Hexosaminidase
OT  - Leukotriene C4
EDAT- 2017/09/30 06:00
MHDA- 2017/09/30 06:01
PMCR- 2017/07/29
CRDT- 2017/09/30 06:00
PHST- 2017/01/30 00:00 [received]
PHST- 2017/07/14 00:00 [revised]
PHST- 2017/07/14 00:00 [accepted]
PHST- 2017/09/30 06:00 [entrez]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2017/09/30 06:01 [medline]
PHST- 2017/07/29 00:00 [pmc-release]
AID - S2214-7500(17)30047-1 [pii]
AID - 10.1016/j.toxrep.2017.07.004 [doi]
PST - epublish
SO  - Toxicol Rep. 2017 Jul 29;4:431-437. doi: 10.1016/j.toxrep.2017.07.004. 
      eCollection 2017.