PMID- 28960280
OWN - NLM
STAT- MEDLINE
DCOM- 20181109
LR  - 20181109
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 48
IP  - 1
DP  - 2018 Jan
TI  - Functional specialization of intestinal dendritic cell subsets during Th2 
      helminth infection in mice.
PG  - 87-98
LID - 10.1002/eji.201747073 [doi]
AB  - Dendritic cells (DCs) are essential in dictating the nature and effectiveness of 
      immune responses. In the intestine DCs can be separated into discrete subsets, 
      defined by expression of CD11b and CD103, each with different developmental 
      requirements and distinct functional potential. Recent evidence has shown that 
      different intestinal DC subsets are involved in the induction of T helper (Th)17 
      and regulatory T cell responses, but the cells that initiate Th2 immune responses 
      are still incompletely understood. We show that in the Th2 response to an 
      intestinal helminth in mice, only CD11b(+) and not CD11b(-) DCs accumulate in the 
      local lymph node, upregulate PDL2 and express markers of alternative activation. 
      An enteric Th1 response instead activated both CD11b(+) and CD11b(-) DCs without 
      eliciting alternative activation in either population. Functionally, only 
      CD11b(+) DCs activated during helminth infection supported Th2 differentiation in 
      naive CD4(+) T cells. Together our data demonstrate that the ability to prime Th2 
      cells during intestinal helminth infection, is a selective and inducible 
      characteristic of CD11b(+) DCs.
CI  - (c) 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
FAU - Redpath, Stephen A
AU  - Redpath SA
AD  - Department of Microbiology and Immunology, University of British Columbia, 
      Vancouver, British Columbia, Canada.
FAU - Heieis, Graham A
AU  - Heieis GA
AD  - Department of Microbiology and Immunology, University of British Columbia, 
      Vancouver, British Columbia, Canada.
AD  - Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary 
      and Life Sciences, University of Glasgow, Glasgow, UK.
FAU - Reynolds, Lisa A
AU  - Reynolds LA
AUID- ORCID: 0000-0002-2969-2296
AD  - Michael Smith Laboratories, University of British Columbia, Vancouver, British 
      Columbia, Canada.
FAU - Fonseca, Nicolette M
AU  - Fonseca NM
AUID- ORCID: 0000-0001-8529-4703
AD  - Department of Microbiology and Immunology, University of British Columbia, 
      Vancouver, British Columbia, Canada.
FAU - Kim, Sandra S-Y
AU  - Kim SS
AUID- ORCID: 0000-0002-7028-2563
AD  - Department of Microbiology and Immunology, University of British Columbia, 
      Vancouver, British Columbia, Canada.
FAU - Perona-Wright, Georgia
AU  - Perona-Wright G
AUID- ORCID: 0000-0003-2761-4275
AD  - Department of Microbiology and Immunology, University of British Columbia, 
      Vancouver, British Columbia, Canada.
AD  - Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary 
      and Life Sciences, University of Glasgow, Glasgow, UK.
LA  - eng
GR  - MOP-126061/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20171102
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens, CD)
RN  - 0 (CD11b Antigen)
RN  - 0 (Il4ra protein, mouse)
RN  - 0 (Integrin alpha Chains)
RN  - 0 (Receptors, Cell Surface)
RN  - 0 (alpha E integrins)
SB  - IM
MH  - Animals
MH  - Antigens, CD/metabolism
MH  - CD11b Antigen/metabolism
MH  - Cell Differentiation/immunology
MH  - Cells, Cultured
MH  - Dendritic Cells/classification/*immunology
MH  - Integrin alpha Chains/metabolism
MH  - Intestinal Mucosa/cytology/immunology/parasitology
MH  - Intestine, Small/cytology/immunology/parasitology
MH  - Lymphocyte Activation/*immunology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Nematospiroides dubius/*immunology
MH  - Receptors, Cell Surface/immunology
MH  - Strongylida Infections/*immunology/parasitology
MH  - Th1 Cells/immunology
MH  - Th2 Cells/*immunology
OTO - NOTNLM
OT  - Alternative activation
OT  - CD11b+ dendritic cells
OT  - Helminth infection
OT  - Programmed Death-Ligand 2
OT  - Th2
EDAT- 2017/09/30 06:00
MHDA- 2018/11/10 06:00
CRDT- 2017/09/30 06:00
PHST- 2017/04/10 00:00 [received]
PHST- 2017/08/08 00:00 [revised]
PHST- 2017/09/20 00:00 [accepted]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2018/11/10 06:00 [medline]
PHST- 2017/09/30 06:00 [entrez]
AID - 10.1002/eji.201747073 [doi]
PST - ppublish
SO  - Eur J Immunol. 2018 Jan;48(1):87-98. doi: 10.1002/eji.201747073. Epub 2017 Nov 2.