PMID- 28960353
OWN - NLM
STAT- MEDLINE
DCOM- 20180710
LR  - 20221207
IS  - 1096-9071 (Electronic)
IS  - 0146-6615 (Linking)
VI  - 90
IP  - 2
DP  - 2018 Feb
TI  - Significant improvement of glycemic control in diabetic patients with HCV 
      infection responding to direct-acting antiviral agents.
PG  - 320-327
LID - 10.1002/jmv.24954 [doi]
AB  - Many studies showed insulin resistance amelioration in HCV-patients achieving 
      Sustained Virologic Response (SVR) but results on glycemic control in diabetic 
      patients are unclear. This study aimed to assess fasting glucose (FG) and 
      glycated hemoglobin (HbA1c) values before and after therapy with direct-acting 
      antivirals (DAAs) in HCV-patients with type 2 diabetes mellitus (T2DM). Of the 
      122 consecutively recruited patients with chronic hepatitis C and T2DM, 110 
      patients were treated with DAAs and 12 remained untreated. Clinical, biochemical, 
      virological, and metabolic features were collected both at baseline and at 12 
      weeks after the end of therapy (EOT) or after a comparable period of time in 
      untreated patients. A total of 101 patients obtained a SVR (Group 1), while nine 
      were relapsers. Group 2 (21 patients) was composed by the nine relapsers and the 
      12 untreated patients. A significant reduction of mean FG (134.3 +/- 41.32 mg/dL vs 
      152.4 +/- 56.40 mg/dL, P = 0.002) and HbA1c values (46.51 +/- 16.15 mmoL/moL vs 
      52.15 +/- 15.43 mmoL/moL, P <  0.001) was found in Group 1 but not in Group 2 
      (140.6 +/- 47.87 mg/dL vs. 145.31 +/- 30.18 mg/dL, P = 0.707, and 
      55.31 +/- 20.58 mmoL/moL vs. 53.38 +/- 9.49 mmoL/moL, P = 0.780). In Group 1, 20.7% 
      of patients could reduce or suspend their antidiabetic therapy compared to none 
      in Group 2 (P = 0.03), despite the significant weight increase observed in Group 
      1. SVR induced a significant amelioration of glycemic control in diabetic 
      HCV-patients, despite a significant weight increase; larger prospective studies 
      are needed to verify whether these results are maintained over the long-term.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Ciancio, Alessia
AU  - Ciancio A
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
FAU - Bosio, Roberta
AU  - Bosio R
AD  - Gastroenterology Unit, San Luigi Hospital, University of Turin, Torino, Italy.
FAU - Bo, Simona
AU  - Bo S
AD  - Department of Medical Sciences, AOU Citta della Salute e della Scienza di Torino, 
      University of Turin, Torino, Italy.
FAU - Pellegrini, Marianna
AU  - Pellegrini M
AD  - Department of Medical Sciences, AOU Citta della Salute e della Scienza di Torino, 
      University of Turin, Torino, Italy.
FAU - Sacco, Marco
AU  - Sacco M
AUID- ORCID: 0000-0003-0975-5584
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
FAU - Vogliotti, Edoardo
AU  - Vogliotti E
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
FAU - Fassio, Giulia
AU  - Fassio G
AD  - Gastroenterology Unit, San Luigi Hospital, University of Turin, Torino, Italy.
FAU - Bianco Mauthe Degerfeld, Andrea G F
AU  - Bianco Mauthe Degerfeld AGF
AD  - Gastroenterology Unit, San Luigi Hospital, University of Turin, Torino, Italy.
FAU - Gallo, Monica
AU  - Gallo M
AD  - Gastroenterology Unit, San Luigi Hospital, University of Turin, Torino, Italy.
FAU - Giordanino, Chiara
AU  - Giordanino C
AD  - Gastroenterology Unit, San Luigi Hospital, University of Turin, Torino, Italy.
FAU - Terzi di Bergamo, Lodovico
AU  - Terzi di Bergamo L
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
FAU - Ribaldone, Davide
AU  - Ribaldone D
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
FAU - Bugianesi, Elisabetta
AU  - Bugianesi E
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
FAU - Smedile, Antonina
AU  - Smedile A
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
FAU - Rizzetto, Mario
AU  - Rizzetto M
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
FAU - Saracco, Giorgio Maria
AU  - Saracco GM
AD  - Gastroenterology Unit, Department of Medical Sciences, AOU Citta della Salute e 
      della Scienza di Torino, University of Turin, Torino, Italy.
LA  - eng
PT  - Journal Article
DEP - 20171114
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Antiviral Agents)
RN  - 0 (Blood Glucose)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (hemoglobin A1c protein, human)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antiviral Agents/*therapeutic use
MH  - Blood Glucose/*analysis
MH  - Diabetes Mellitus, Type 2/*pathology
MH  - Female
MH  - Glycated Hemoglobin/*analysis
MH  - Hepatitis C, Chronic/*complications/*drug therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Treatment Outcome
MH  - Young Adult
OTO - NOTNLM
OT  - anti-hepatitis C virus DAA
OT  - hepatitis C virus
OT  - hepatitis virus
EDAT- 2017/09/30 06:00
MHDA- 2018/07/11 06:00
CRDT- 2017/09/30 06:00
PHST- 2017/08/14 00:00 [received]
PHST- 2017/09/19 00:00 [accepted]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2018/07/11 06:00 [medline]
PHST- 2017/09/30 06:00 [entrez]
AID - 10.1002/jmv.24954 [doi]
PST - ppublish
SO  - J Med Virol. 2018 Feb;90(2):320-327. doi: 10.1002/jmv.24954. Epub 2017 Nov 14.