PMID- 28960421
OWN - NLM
STAT- MEDLINE
DCOM- 20190415
LR  - 20231112
IS  - 1943-278X (Electronic)
IS  - 0363-0234 (Print)
IS  - 0363-0234 (Linking)
VI  - 49
IP  - 1
DP  - 2019 Feb
TI  - Circulating Levels of Brain-Derived Neurotrophic Factor and History of Suicide 
      Attempts in Women.
PG  - 54-63
LID - 10.1111/sltb.12403 [doi]
AB  - A growing body of research examining biological factors associated with suicidal 
      behaviors highlights the role of brain-derived neurotropic factor (BDNF), 
      involved in neurogenesis and synaptic plasticity. There is evidence suggesting 
      that suicide attempters have lower BDNF levels than those with no history of 
      suicide attempts. The key question addressed in the current investigation is 
      whether differences in circulating BDNF levels persist beyond the current 
      suicidal episode and would be observed in those with a past history of suicide 
      attempts (SA). Plasma levels of BDNF were assessed in 73 women from the 
      community. We found that women with a history of SA exhibited lower levels of 
      BDNF than women with no SA history and this difference was maintained after 
      statistically controlling for the influence of other potential psychiatric or 
      demographic factors. These findings support and extend existing research by 
      suggesting that circulating BDNF levels are decreased among individuals with a 
      history of SA compared to individuals with no history of SA. This relation 
      appeared to be specific to women's history of SA and was not explained by other 
      potential psychiatric or demographic factors, which further highlights the role 
      of BDNF as a promising biomarker for suicidal behavior.
CI  - (c) 2017 The American Association of Suicidology.
FAU - Kudinova, Anastacia Y
AU  - Kudinova AY
AUID- ORCID: 0000-0002-3799-5924
AD  - Center for Affective Science, Binghamton University (SUNY), Binghamton, NY, USA.
FAU - Deak, Terrence
AU  - Deak T
AD  - Center for Affective Science, Binghamton University (SUNY), Binghamton, NY, USA.
FAU - Deak, Molly M
AU  - Deak MM
AD  - Center for Affective Science, Binghamton University (SUNY), Binghamton, NY, USA.
FAU - Gibb, Brandon E
AU  - Gibb BE
AD  - Center for Affective Science, Binghamton University (SUNY), Binghamton, NY, USA.
LA  - eng
GR  - R01 MH098060/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20170928
PL  - England
TA  - Suicide Life Threat Behav
JT  - Suicide & life-threatening behavior
JID - 7608054
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Adult
MH  - *Behavioral Symptoms/blood/prevention & control/psychology
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Correlation of Data
MH  - Female
MH  - Humans
MH  - *Suicidal Ideation
MH  - *Suicide, Attempted/prevention & control/psychology
PMC - PMC5874157
MID - NIHMS897471
COIS- Conflict of Interest The authors declare no conflict of interest.
EDAT- 2017/09/30 06:00
MHDA- 2019/04/16 06:00
PMCR- 2020/02/01
CRDT- 2017/09/30 06:00
PHST- 2017/06/22 00:00 [received]
PHST- 2017/07/07 00:00 [accepted]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2019/04/16 06:00 [medline]
PHST- 2017/09/30 06:00 [entrez]
PHST- 2020/02/01 00:00 [pmc-release]
AID - 10.1111/sltb.12403 [doi]
PST - ppublish
SO  - Suicide Life Threat Behav. 2019 Feb;49(1):54-63. doi: 10.1111/sltb.12403. Epub 
      2017 Sep 28.