PMID- 28960673
OWN - NLM
STAT- MEDLINE
DCOM- 20181016
LR  - 20220318
IS  - 1879-0844 (Electronic)
IS  - 1388-9842 (Linking)
VI  - 20
IP  - 1
DP  - 2018 Jan
TI  - Screening for heart transplantation and left ventricular assist system: results 
      from the ScrEEning for advanced Heart Failure treatment (SEE-HF) study.
PG  - 152-160
LID - 10.1002/ejhf.975 [doi]
AB  - BACKGROUND: Heart transplantation (HTx) and implantable left ventricular assist 
      systems (LVAS) improve outcomes in advanced heart failure but may be 
      underutilized. We hypothesized that screening can identify appropriate 
      candidates. METHODS AND RESULTS: The ScrEEning for advanced Heart Failure 
      treatment (SEE-HF) study was a multicentre prospective study screening patients 
      with existing cardiac resynchronization therapy (CRT) and/or implantable 
      cardioverter-defibrillator (ICD) for ejection fraction </=40% and New York Heart 
      Association (NYHA) class III-IV, and subsequently for guideline-based HTx and 
      LVAS indication. Of 1722 (mean age 64 +/- 14 years, 26% women) patients screened at 
      eight centres in seven European countries, 121 (7.0%) were eligible and 99 (5.7%; 
      mean age 61 +/- 10 years, 19% women) patients were enrolled for detailed 
      assessment. Twenty-six of the 99 enrolled patients (26%) were eligible for either 
      HTx or LVAD (18 eligible for HTx; 7 eligible for LVAD; and 1 eligible for both). 
      Eleven patients were listed for HTx and three received an LVAS. Eligible patients 
      were 61 +/- 8 years and 19% women, whereas those actually receiving intervention 
      were 56 +/- 8 years and 8% women. CONCLUSIONS: Among patients with CRT and/or ICD, 
      a minority have NYHA class III-IV heart failure and ejection fraction </=40%. Among 
      these, however, more than one-quarter have an unrecognized need for HTx or LVAS. 
      When patients are offered intervention based on screening, many decline. 
      Discrepancies exist between clinical and patient equipoise. Clinical Trial 
      Registration ClinicalTrials.gov Unique Identifier: NCT00894387.
CI  - (c) 2017 The Authors. European Journal of Heart Failure (c) 2017 European Society of 
      Cardiology.
FAU - Lund, Lars H
AU  - Lund LH
AD  - Department of Medicine, Karolinska Institutet, Stockholm, Sweden.
AD  - Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
FAU - Trochu, Jean-Noel
AU  - Trochu JN
AD  - Institut du Thorax, Inserm UMR 1087-CIC1413, Centre Hospitalier Universaire de 
      Nantes, Nantes, France.
FAU - Meyns, Bart
AU  - Meyns B
AD  - UZ Leuven, Leuven, Belgium.
FAU - Caliskan, Kadir
AU  - Caliskan K
AD  - Erasmus MC University Medical Center, Rotterdam, The Netherlands.
FAU - Shaw, Steven
AU  - Shaw S
AD  - University Hospital of S. Manchester NHS Trust, Manchester, UK.
FAU - Schmitto, Jan D
AU  - Schmitto JD
AD  - Department of Cardiac, Thoracic, Transplantation and Vascular Surgery, Hannover 
      Medical School, Hannover, Germany.
FAU - Schibilsky, David
AU  - Schibilsky D
AD  - German Heart Competance Center, University Clinical Center Tuebingen, Tuebingen, 
      Germany.
FAU - Damme, Laura
AU  - Damme L
AD  - St Jude Medical, Minneapolis, MN, USA.
FAU - Heatley, Jerry
AU  - Heatley J
AD  - St Jude Medical, Minneapolis, MN, USA.
FAU - Gustafsson, Finn
AU  - Gustafsson F
AD  - Department of Cardiology, Copenhagen University Hospital Rigshospitalet, 
      Copenhagen, Denmark.
LA  - eng
SI  - ClinicalTrials.gov/NCT00894387
PT  - Clinical Trial, Phase IV
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20170927
PL  - England
TA  - Eur J Heart Fail
JT  - European journal of heart failure
JID - 100887595
SB  - IM
CIN - Eur J Heart Fail. 2018 Jan;20(1):161-163. PMID: 29148255
MH  - Cardiac Resynchronization Therapy/methods
MH  - Europe/epidemiology
MH  - Female
MH  - Heart Failure/mortality/physiopathology/*surgery
MH  - Heart Transplantation/*statistics & numerical data
MH  - Heart Ventricles/*physiopathology
MH  - Heart-Assist Devices/*statistics & numerical data
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk Factors
MH  - Survival Rate/trends
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Heart failure
OT  - Heart transplantation
OT  - Left ventricular assist system
OT  - Mechanical circulatory support
OT  - Screening
EDAT- 2017/09/30 06:00
MHDA- 2018/10/17 06:00
CRDT- 2017/09/30 06:00
PHST- 2017/04/12 00:00 [received]
PHST- 2017/07/22 00:00 [revised]
PHST- 2017/07/25 00:00 [accepted]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2018/10/17 06:00 [medline]
PHST- 2017/09/30 06:00 [entrez]
AID - 10.1002/ejhf.975 [doi]
PST - ppublish
SO  - Eur J Heart Fail. 2018 Jan;20(1):152-160. doi: 10.1002/ejhf.975. Epub 2017 Sep 
      27.