PMID- 28960774
OWN - NLM
STAT- MEDLINE
DCOM- 20181105
LR  - 20181105
IS  - 2047-6310 (Electronic)
IS  - 2047-6302 (Linking)
VI  - 13
IP  - 3
DP  - 2018 Mar
TI  - The BDNF Val66Met polymorphism is associated with lower BMI, lower postprandial 
      glucose levels and elevated carbohydrate intake in children and adolescents.
PG  - 159-167
LID - 10.1111/ijpo.12238 [doi]
AB  - BACKGROUND: The amino acid-changing exonic variant rs6265 (Val66Met polymorphism) 
      in the brain-derived neurotrophic factor (BDNF) has been linked to obesity in 
      several genotype-phenotype association studies. OBJECTIVE: To identify metabolic 
      factors by which this effect might be conveyed, we aimed to investigate its 
      correlation with (i) obesity, (ii) metabolic parameters, (iii) serum levels of 
      BDNF and (iv) measures of energy intake in children and adolescents. METHODS: We 
      genotyped the variant in 2131 subjects (age 6-18 years) and checked for an 
      association with obesity. Secondly, we correlated the genotype with parameters of 
      glucose and lipid metabolism (fasting/postprandial glucose and insulin levels, 
      HbA1c, homeostasis model assessment, Matsuda, high-density lipoprotein, 
      low-density lipoprotein, total cholesterol and triglycerides) in a smaller subset 
      of 845 subjects. We determined BDNF serum levels in 177 individuals by 
      enzyme-linked immunosorbent assay and assessed the association with genotype and 
      metabolic parameters. Finally, we investigated the association between genotype 
      and macronutrient intake from self-reported food diaries (n = 146). RESULTS: The 
      minor Met allele was associated with lower BMI standard deviation score 
      (p = 0.002). Post-pubertal Met allele carriers showed lower postprandial glucose 
      levels and a lower HbA1c (beta = 0.15, p = 0.046 and beta = 0.27, p = 0.012, 
      respectively). Neither the genotype nor any of the metabolic parameters 
      correlated with BDNF serum levels. We observed an increased total calorie intake 
      (beta = -0.21, p = 0.007) with increased carbohydrate and protein intake (beta = -0.22, 
      p = 0.005 and beta = -0.14, p = 0.028, respectively) in Met allele carriers. 
      CONCLUSIONS: We confirmed the association of the minor Met allele with lower BMI 
      in children and provide new data that it is associated with lower postprandial 
      glucose in post-pubertal subjects. Moreover, Met allele carriers reported to 
      consume more carbohydrates and proteins.
CI  - (c) 2017 World Obesity Federation.
FAU - Kalenda, A
AU  - Kalenda A
AD  - Center for Pediatric Research Leipzig (CPL), University Hospital for Children and 
      Adolescents, University Hospital Leipzig, Leipzig, Germany.
AD  - Integrated Research and Treatment Centre (IFB) AdiposityDiseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Landgraf, K
AU  - Landgraf K
AD  - Center for Pediatric Research Leipzig (CPL), University Hospital for Children and 
      Adolescents, University Hospital Leipzig, Leipzig, Germany.
AD  - Integrated Research and Treatment Centre (IFB) AdiposityDiseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Loffler, D
AU  - Loffler D
AD  - Center for Pediatric Research Leipzig (CPL), University Hospital for Children and 
      Adolescents, University Hospital Leipzig, Leipzig, Germany.
AD  - Integrated Research and Treatment Centre (IFB) AdiposityDiseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Kovacs, P
AU  - Kovacs P
AD  - Integrated Research and Treatment Centre (IFB) AdiposityDiseases, University of 
      Leipzig, Leipzig, Germany.
FAU - Kiess, W
AU  - Kiess W
AD  - Center for Pediatric Research Leipzig (CPL), University Hospital for Children and 
      Adolescents, University Hospital Leipzig, Leipzig, Germany.
FAU - Korner, A
AU  - Korner A
AD  - Center for Pediatric Research Leipzig (CPL), University Hospital for Children and 
      Adolescents, University Hospital Leipzig, Leipzig, Germany.
AD  - Integrated Research and Treatment Centre (IFB) AdiposityDiseases, University of 
      Leipzig, Leipzig, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170927
PL  - England
TA  - Pediatr Obes
JT  - Pediatric obesity
JID - 101572033
RN  - 0 (Blood Glucose)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Lipids)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Alleles
MH  - Blood Glucose/*genetics
MH  - Body Mass Index
MH  - Brain-Derived Neurotrophic Factor/blood/*genetics
MH  - Carbohydrate Metabolism/genetics
MH  - Child
MH  - Energy Intake/*genetics
MH  - Feeding Behavior
MH  - Female
MH  - Genotype
MH  - Humans
MH  - Lipid Metabolism/genetics
MH  - Lipids/blood
MH  - Male
MH  - Pediatric Obesity/*genetics
MH  - Polymorphism, Single Nucleotide
MH  - Postprandial Period
OTO - NOTNLM
OT  - BDNF
OT  - Val66Met polymorphism
OT  - glucose metabolism - children
OT  - obesity
EDAT- 2017/09/30 06:00
MHDA- 2018/11/06 06:00
CRDT- 2017/09/30 06:00
PHST- 2017/04/09 00:00 [received]
PHST- 2017/08/05 00:00 [accepted]
PHST- 2017/09/30 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2017/09/30 06:00 [entrez]
AID - 10.1111/ijpo.12238 [doi]
PST - ppublish
SO  - Pediatr Obes. 2018 Mar;13(3):159-167. doi: 10.1111/ijpo.12238. Epub 2017 Sep 27.