PMID- 2896150
OWN - NLM
STAT- MEDLINE
DCOM- 19880608
LR  - 20031114
IS  - 0367-6102 (Print)
IS  - 0367-6102 (Linking)
VI  - 63
IP  - 1
DP  - 1988 Jan
TI  - Effects of SGB-1534, a new synthesized phenylpiperazine derivative, on blood 
      pressure and heart rate in stroke-prone spontaneously hypertensive rats.
PG  - 36-43
AB  - The present study was undertaken to elucidate the effects of a new synthesized 
      phenylpiperazine derivative SGB-1534 on mean arterial blood pressure and heart 
      rate in stroke-prone spontaneously hypertensive rats(SHRSP). SGB-1534 (0.05 and 
      0.5 mg/kg, i.v.) produced a significantly greater decrease in mean arterial blood 
      pressure in SHRSP than in normotensive Wistar Kyoto rats(WKY). Heart rate also 
      tended to decrease in parallel with the decrease in mean arterial blood pressure 
      in SHRSP. In this study, it was revealed that SGB-1534 has an antihypertensive 
      effect in SHRSP. An attempt was made to elucidate the hypotensive mechanism of 
      SGB-1534 using WKY. SGB-1534 (0.5 mg/kg, i.v.) significantly inhibited pressor 
      responses to norepinephrine (5 micrograms/kg, i.v.) and methoxamine (50 
      micrograms/kg, i.v.). SGB-1534 (0.5 mg/kg, i.v.) did not affect the preganglionic 
      sympathetic adrenal nerve activity. The present findings suggest that the action 
      site of SGB-1534 is not in the central nervous system, but in the peripheral 
      alpha 1-adrenoceptors in rats.
FAU - Matsumoto, M
AU  - Matsumoto M
AD  - First Department of Pharmacology, Hokkaido University School of Medicine, 
      Sapporo, Japan.
FAU - Yoshioka, M
AU  - Yoshioka M
FAU - Togashi, H
AU  - Togashi H
FAU - Minami, M
AU  - Minami M
FAU - Nagao, A
AU  - Nagao A
FAU - Saito, H
AU  - Saito H
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Hokkaido Igaku Zasshi
JT  - [Hokkaido igaku zasshi] The Hokkaido journal of medical science
JID - 17410290R
RN  - 0 (Adrenergic alpha-Antagonists)
RN  - 0 (Catecholamines)
RN  - 0 (Quinazolines)
RN  - 88068-72-8 (SGB 1534)
SB  - IM
MH  - Adrenergic Fibers/drug effects/physiology
MH  - Adrenergic alpha-Antagonists/*pharmacology
MH  - Animals
MH  - Blood Pressure/*drug effects
MH  - Catecholamines/blood
MH  - Heart Rate/*drug effects
MH  - Male
MH  - Quinazolines/*pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
EDAT- 1988/01/01 00:00
MHDA- 1988/01/01 00:01
CRDT- 1988/01/01 00:00
PHST- 1988/01/01 00:00 [pubmed]
PHST- 1988/01/01 00:01 [medline]
PHST- 1988/01/01 00:00 [entrez]
PST - ppublish
SO  - Hokkaido Igaku Zasshi. 1988 Jan;63(1):36-43.