PMID- 28962894
OWN - NLM
STAT- MEDLINE
DCOM- 20190212
LR  - 20190215
IS  - 1872-8057 (Electronic)
IS  - 0303-7207 (Linking)
VI  - 462
IP  - Pt B
DP  - 2018 Feb 15
TI  - Sympathetic innervation is essential for metabolic homeostasis and pancreatic 
      beta cell function in adult rats.
PG  - 119-126
LID - S0303-7207(17)30516-6 [pii]
LID - 10.1016/j.mce.2017.09.031 [doi]
AB  - Obesity is associated with an imbalance in the activity of the autonomic nervous 
      system (ANS), specifically in the organs involved in energy metabolism. The 
      pancreatic islets are richly innervated by the ANS, which tunes the insulin 
      release due to changes in energy demand. Therefore, changes in the sympathetic 
      input that reach the pancreas can lead to metabolic dysfunctions. To evaluate the 
      role of the sympathetic ends that innervate the pancreas, 60-day-old male Wistar 
      rats were subjected to sympathectomy (SYM) or were sham-operated (SO). At 120 
      day-old SYM rats exhibited an increase in body weight, fat pads and metabolic 
      dysfunctions. Decreases in the HOMA-IR and reductions in insulin release were 
      observed both in vivo and in vitro. Furthermore, the SYM rats exhibited altered 
      pancreatic islet function in both muscarinic and adrenergic assays and exhibited 
      high protein expression of the alpha-2 adrenergic receptor (alpha2AR). Because alpha2AR 
      has been linked to type 2 diabetes, these findings demonstrate the clinical 
      implications of this study.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Prates, Kelly V
AU  - Prates KV
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil. Electronic 
      address: kvp.86@hotmail.com.
FAU - de Oliveira, Julio C
AU  - de Oliveira JC
AD  - Institute of Health Sciences, Federal University of Mato Grosso, Sinop, MT, 
      Brazil.
FAU - Malta, Ananda
AU  - Malta A
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Matiusso, Camila C I
AU  - Matiusso CCI
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Miranda, Rosiane A
AU  - Miranda RA
AD  - Carlos Chagas Filho Biophysics Institute, Federal University of Rio de Janeiro, 
      Rio de Janeiro, RJ, Brazil.
FAU - Ribeiro, Tatiane A
AU  - Ribeiro TA
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Francisco, Flavio A
AU  - Francisco FA
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Franco, Claudineia C S
AU  - Franco CCS
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Moreira, Veridiana M
AU  - Moreira VM
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Alves, Vander S
AU  - Alves VS
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Torrezan, Rosana
AU  - Torrezan R
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Mathias, Paulo C F
AU  - Mathias PCF
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
FAU - Barella, Luiz F
AU  - Barella LF
AD  - Laboratory of Secretion Cell Biology, Department of Biotechnology, Genetics and 
      Cell Biology, State University of Maringa, Maringa, Parana, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170928
PL  - Ireland
TA  - Mol Cell Endocrinol
JT  - Molecular and cellular endocrinology
JID - 7500844
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Receptors, Adrenergic, alpha-2)
SB  - IM
MH  - Aging
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - Cells, Cultured
MH  - Diabetes Mellitus, Type 2/*physiopathology
MH  - *Homeostasis
MH  - Insulin/*metabolism
MH  - Insulin Resistance
MH  - Islets of Langerhans/cytology/*physiology
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Receptors, Adrenergic, alpha-2/metabolism
MH  - Sympathetic Nervous System/*metabolism
OTO - NOTNLM
OT  - Alpha-2 adrenergic receptor
OT  - Autonomic nervous system
OT  - Endocrine pancreas
OT  - Insulin release
OT  - Metabolism
OT  - Sympathectomy
EDAT- 2017/10/01 06:00
MHDA- 2019/02/13 06:00
CRDT- 2017/10/01 06:00
PHST- 2017/06/28 00:00 [received]
PHST- 2017/09/24 00:00 [revised]
PHST- 2017/09/26 00:00 [accepted]
PHST- 2017/10/01 06:00 [pubmed]
PHST- 2019/02/13 06:00 [medline]
PHST- 2017/10/01 06:00 [entrez]
AID - S0303-7207(17)30516-6 [pii]
AID - 10.1016/j.mce.2017.09.031 [doi]
PST - ppublish
SO  - Mol Cell Endocrinol. 2018 Feb 15;462(Pt B):119-126. doi: 
      10.1016/j.mce.2017.09.031. Epub 2017 Sep 28.