PMID- 28962922
OWN - NLM
STAT- MEDLINE
DCOM- 20180606
LR  - 20180606
IS  - 1872-9754 (Electronic)
IS  - 0197-0186 (Linking)
VI  - 110
DP  - 2017 Nov
TI  - Treadmill exercise alleviated prenatal buprenorphine exposure-induced depression 
      in rats.
PG  - 91-100
LID - S0197-0186(17)30286-3 [pii]
LID - 10.1016/j.neuint.2017.09.012 [doi]
AB  - Mounting evidence suggests that physical exercise shows health benefits in a 
      range of diseases, including psychiatric disorders. Perinatal opioid exposure 
      produces neurobehavioral abnormality, which includes depression symptoms, in 
      patients and their offspring following chronic use of buprenorphine, a mixed 
      agonist/antagonist with a high affinity to opioid receptors, for pain control. 
      Previously, we demonstrated that prenatal buprenorphine exposure in pregnant 
      Sprague-Dawley rats starting from gestation day 7 and lasting for 14 days caused 
      the development of depression-like phenotypes in pups at postnatal day 21. Using 
      the same prenatal buprenorphine exposure model, we further demonstrated that a 
      4-week course of moderate treadmill exercise conducted on pups starting from 
      postnatal day 22 improved depression-like neurobehaviors. Prenatal buprenorphine 
      exposure-induced neurobehavioral changes were accompanied by reductions of 
      neuronal survival, neural stem cell-associated genes, plasma level of 
      brain-derived neurotrophic factor (BDNF) and serotonin, phosphorylated 
      tropomyosin-related kinase receptor type B (TrkB), phosphorylated extracellular 
      signal-regulated kinase (ERK), PKA activity, phosphorylated cAMP response 
      element-binding protein (CREB), and CREB DNA binding activity, as well as 
      elevation of repressor element-1 silencing transcription factor (REST), oxidative 
      stress, and inflammatory responses. Those changes in parameters of plasma and 
      brain were improved by treadmill exercise. In conclusion, the findings of the 
      current study suggest that a non-pharmacological option, i.e., moderate treadmill 
      exercise, alleviated the development of depression-like neurobehaviors by 
      resolving the oxidative and inflammatory burden as well as by enhancing 
      neurochemical and neuroendocrine signaling.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Wu, Chih-Cheng
AU  - Wu CC
AD  - Department of Anesthesiology, Taichung Veterans General Hospital, Taichung City 
      407, Taiwan; Department of Financial and Computational Mathematics, Providence 
      University, Taichung City 433, Taiwan.
FAU - Hung, Chih-Jen
AU  - Hung CJ
AD  - Department of Anesthesiology, Taichung Veterans General Hospital, Taichung City 
      407, Taiwan.
FAU - Lin, Shih-Yi
AU  - Lin SY
AD  - Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, 
      Taichung City 407, Taiwan.
FAU - Wang, Ya-Yu
AU  - Wang YY
AD  - Division of Family Medicine, Taichung Veterans General Hospital, Taichung City 
      407, Taiwan.
FAU - Chang, Cheng-Yi
AU  - Chang CY
AD  - Department of Surgery, Feng Yuan Hospital, Taichung City 420, Taiwan.
FAU - Chen, Wen-Ying
AU  - Chen WY
AD  - Department of Veterinary Medicine, National Chung Hsing University, Taichung City 
      402, Taiwan.
FAU - Liao, Su-Lan
AU  - Liao SL
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung City 
      407, Taiwan.
FAU - Raung, Shue-Ling
AU  - Raung SL
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung City 
      407, Taiwan.
FAU - Yang, Ching-Ping
AU  - Yang CP
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung City 
      407, Taiwan.
FAU - Chen, Chun-Jung
AU  - Chen CJ
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung City 
      407, Taiwan; Department of Medical Laboratory Science and Biotechnology, China 
      Medical University, Taichung City 404, Taiwan. Electronic address: 
      cjchen@vghtc.gov.tw.
LA  - eng
PT  - Journal Article
DEP - 20170927
PL  - England
TA  - Neurochem Int
JT  - Neurochemistry international
JID - 8006959
RN  - 0 (Analgesics, Opioid)
RN  - 40D3SCR4GZ (Buprenorphine)
SB  - IM
MH  - Analgesics, Opioid/toxicity
MH  - Animals
MH  - Buprenorphine/*toxicity
MH  - Depression/*chemically induced/psychology/*therapy
MH  - Exercise Test/*methods/psychology
MH  - Female
MH  - Physical Conditioning, Animal/methods/psychology
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced/psychology/*therapy
MH  - Rats
MH  - Rats, Sprague-Dawley
OTO - NOTNLM
OT  - Depression
OT  - Neuroendocrine
OT  - Neurotrophin
OT  - Opioid
OT  - Treadmill exercise
EDAT- 2017/10/01 06:00
MHDA- 2018/06/07 06:00
CRDT- 2017/10/01 06:00
PHST- 2017/05/11 00:00 [received]
PHST- 2017/09/05 00:00 [revised]
PHST- 2017/09/24 00:00 [accepted]
PHST- 2017/10/01 06:00 [pubmed]
PHST- 2018/06/07 06:00 [medline]
PHST- 2017/10/01 06:00 [entrez]
AID - S0197-0186(17)30286-3 [pii]
AID - 10.1016/j.neuint.2017.09.012 [doi]
PST - ppublish
SO  - Neurochem Int. 2017 Nov;110:91-100. doi: 10.1016/j.neuint.2017.09.012. Epub 2017 
      Sep 27.