PMID- 2896386
OWN - NLM
STAT- MEDLINE
DCOM- 19880608
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 240
IP  - 4852
DP  - 1988 Apr 29
TI  - Seroprevalence and epidemiological correlates of HTLV-I infection in U.S. blood 
      donors.
PG  - 643-6
AB  - Screening for human T-lymphotropic virus type I (HTLV-I) antibodies was performed 
      on sera from 39,898 blood donors at eight blood centers in geographically 
      distinct areas of the United States. Ten donors (0.025 percent) showed evidence 
      of HTLV-I seropositivity by enzyme immunoassays; this was confirmed by protein 
      immunoblot and radioimmunoprecipitation. Seroprevalence rates ranged from 0 to 
      0.10 percent at the locations sampled, with HTLV-I antibodies found predominantly 
      in donors from the southeastern and southwestern United States. Matched 
      case-control interviews and laboratory studies were performed on five 
      seropositive women and two seropositive men who participated in an 
      identity-linked collection of sera from a subset of 33,893 donors at six of the 
      eight blood centers. Four of the women and both men are black; one woman is 
      Caucasian. Four of the seven seropositive individuals admitted to prior 
      intravenous drug abuse or sexual contact with an intravenous drug user. Sexual 
      contact with native inhabitants of an HTLV-I endemic area was the only identified 
      risk factor for one male. The distribution of HTLV-I antibodies in this U.S. 
      blood donor sample corroborates the previously reported epidemiology of this 
      agent and suggests that additional donor screening measures, including the 
      testing of donated blood for HTLV-I markers, may be necessary to prevent the 
      spread of HTLV-I to transfusion recipients.
FAU - Williams, A E
AU  - Williams AE
AD  - American Red Cross Jerome H. Holland Laboratory, Rockville, MD 20855.
FAU - Fang, C T
AU  - Fang CT
FAU - Slamon, D J
AU  - Slamon DJ
FAU - Poiesz, B J
AU  - Poiesz BJ
FAU - Sandler, S G
AU  - Sandler SG
FAU - Darr, W F 2nd
AU  - Darr WF 2nd
FAU - Shulman, G
AU  - Shulman G
FAU - McGowan, E I
AU  - McGowan EI
FAU - Douglas, D K
AU  - Douglas DK
FAU - Bowman, R J
AU  - Bowman RJ
AU  - et al.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Antibodies, Viral)
SB  - IM
EIN - Science 1989 May 19;244(4906):757
MH  - Adult
MH  - Antibodies, Viral/*analysis
MH  - *Blood Donors
MH  - Deltaretrovirus/*immunology/isolation & purification
MH  - Deltaretrovirus Infections/diagnosis/*epidemiology/transmission
MH  - Female
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Immunosorbent Techniques
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Risk Factors
MH  - Sexual Partners
MH  - Substance-Related Disorders
MH  - United States
EDAT- 1988/04/29 00:00
MHDA- 1988/04/29 00:01
CRDT- 1988/04/29 00:00
PHST- 1988/04/29 00:00 [pubmed]
PHST- 1988/04/29 00:01 [medline]
PHST- 1988/04/29 00:00 [entrez]
AID - 10.1126/science.2896386 [doi]
PST - ppublish
SO  - Science. 1988 Apr 29;240(4852):643-6. doi: 10.1126/science.2896386.