PMID- 28963930
OWN - NLM
STAT- MEDLINE
DCOM- 20171026
LR  - 20171120
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 91
DP  - 2017 Nov
TI  - Oligomeric proanthocyanidins attenuate airway inflammation in asthma by 
      inhibiting dendritic cells maturation.
PG  - 209-217
LID - S0161-5890(17)30511-4 [pii]
LID - 10.1016/j.molimm.2017.09.012 [doi]
AB  - To date, although a promising anti-inflammatory activity of oligomeric 
      proanthocyanidins (OPCs) has been observed in asthma, the mechanism responsible 
      for these immunomodulatory properties remains obscure. Dendritic cells (DCs) that 
      reside in the airway have been widely perceived as an important contributor to 
      asthma. Our study was to demonstrate OPCs' effects on maturation and 
      immunoregulation of pulmonary CD11c(+) dendritic cells (DCs). BALB/c mice were 
      exposed to ovalbumin (OVA) to induce murine model of asthma. In addition, 
      pulmonary DCs and bone marrow-derived DCs (BMDCs) cultures were used to evaluate 
      impacts of OPCs on DCs function. The results obtained here indicated that OPCs 
      treatment dramatically reduced airway inflammation, such as the infiltration of 
      inflammatory cells and the levels of allergen-specific serum IgE and Th2 
      cytokines. The expression of co-stimulatory molecules especially CD86 distributed 
      on pulmonary DCs and bone marrow-derived DCs (BMDCs) also markedly declined. The 
      phosphorylation of cAMP responsive element-binding protein (CREB) was 
      significantly inhibited while no changes were observed in the expression of cAMP 
      responsive element modulator (CREM). By transferring BMDCs into the airways of 
      naive mice, we found that OPCs-treated DCs (DC+OVA+OPC) were much less potent in 
      promoting CD4(+) T cells proliferation than OVA-pulsed DCs (DC+OVA), followed by 
      the ameliorated eosinophilic inflammation in airway. Our findings tailor a novel 
      profile of OPCs in the regulation of DCs function, shedding new light on the 
      therapeutic potential of OPCs in asthma management.
CI  - Copyright (c) 2017 Elsevier Ltd. All rights reserved.
FAU - Li, Yeshan
AU  - Li Y
AD  - Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital 
      of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, 
      China.
FAU - Yu, Qijun
AU  - Yu Q
AD  - Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital 
      of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, 
      China.
FAU - Zhao, Wenxue
AU  - Zhao W
AD  - Lung Biology Center, Department of Medicine, University of California San 
      Francisco, San Francisco, California 94143, USA.
FAU - Zhang, Jiaxiang
AU  - Zhang J
AD  - Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital 
      of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, 
      China.
FAU - Liu, Wentao
AU  - Liu W
AD  - Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing 
      Medical University, 140 Guangzhou Road, Nanjing, Jiangsu 210017, China.
FAU - Huang, Mao
AU  - Huang M
AD  - Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital 
      of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, 
      China. Electronic address: huangmao6114@126.com.
FAU - Zeng, Xiaoning
AU  - Zeng X
AD  - Department of Respiratory & Critical Care Medicine, The First Affiliated Hospital 
      of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, 
      China. Electronic address: zeng_xiao_ning@hotmail.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170930
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (B7-2 Antigen)
RN  - 0 (CD11c Antigen)
RN  - 0 (Cd86 protein, mouse)
RN  - 0 (Cytokines)
RN  - 0 (Proanthocyanidins)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (Crebbp protein, mouse)
SB  - IM
MH  - Animals
MH  - Asthma/chemically induced/*immunology/pathology
MH  - B7-2 Antigen/immunology
MH  - CD11c Antigen/immunology
MH  - CREB-Binding Protein/immunology
MH  - Cell Proliferation/drug effects
MH  - Cytokines/immunology
MH  - Dendritic Cells/*immunology/pathology
MH  - Female
MH  - Immunoglobulin E/immunology
MH  - Inflammation/chemically induced/immunology/pathology
MH  - Lung/*immunology/pathology
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Phosphorylation/drug effects/immunology
MH  - Proanthocyanidins/*pharmacology
MH  - Th2 Cells/immunology/pathology
OTO - NOTNLM
OT  - Asthma
OT  - CD86
OT  - CREB
OT  - Dendritic cells
OT  - Oligomeric proanthocyanidins
EDAT- 2017/10/01 06:00
MHDA- 2017/10/27 06:00
CRDT- 2017/10/01 06:00
PHST- 2017/06/12 00:00 [received]
PHST- 2017/09/18 00:00 [revised]
PHST- 2017/09/22 00:00 [accepted]
PHST- 2017/10/01 06:00 [pubmed]
PHST- 2017/10/27 06:00 [medline]
PHST- 2017/10/01 06:00 [entrez]
AID - S0161-5890(17)30511-4 [pii]
AID - 10.1016/j.molimm.2017.09.012 [doi]
PST - ppublish
SO  - Mol Immunol. 2017 Nov;91:209-217. doi: 10.1016/j.molimm.2017.09.012. Epub 2017 
      Sep 30.