PMID- 28964610
OWN - NLM
STAT- MEDLINE
DCOM- 20171211
LR  - 20171211
IS  - 1532-2157 (Electronic)
IS  - 0748-7983 (Linking)
VI  - 43
IP  - 12
DP  - 2017 Dec
TI  - Correlation of clinicopathologic features and lung squamous cell carcinoma 
      subtypes according to the 2015 WHO classification.
PG  - 2308-2314
LID - S0748-7983(17)30701-1 [pii]
LID - 10.1016/j.ejso.2017.09.011 [doi]
AB  - AIMS: This study aimed to determine the relationship between clinicopathologic 
      features and lung squamous cell carcinoma (LSCC) subtypes according to the 2015 
      WHO classification. METHODS: We identified 824 operable LSCC patients undergoing 
      a complete surgical resection at Shanghai Chest Hospital between April 2015 and 
      January 2017. Immunohistochemistry was used to investigate the clinicopathologic 
      features. RESULTS: Among them, the percentages of LSCC subtypes were 66.1% 
      (545/824), 28.6% (236/824), and 5.2% (43/824) for keratinizing squamous cell 
      carcinoma (KSCC), nonkeratinizing squamous cell carcinoma (NKSCC), and basaloid 
      squamous cell carcinoma (BSCC), respectively. There were more males, more 
      smokers, and more pneumonectomy surgeries in KSCC patients (p = 0.008, p = 0.000, 
      p = 0.043). There were more N2 lymph node involvement and pathological stage III 
      in NKSCC patients (p = 0.01, p = 0.03). BSCC did not demonstrate specificity to 
      anything, but expressed adenocarcinoma markers more frequently. No significant 
      difference existed between pathological subtypes and other clinicopathologic 
      features, such as age, location type, visceral pleural involvement and 
      lymphovascular invasion. The frequencies of EGFR sensitive mutations and ALK 
      rearrangements were not significantly different among three subtypes. CONCLUSION: 
      Significant relationships exist between some clinicopathologic features and LSCC 
      subtypes.
CI  - Copyright (c) 2017 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the 
      European Society of Surgical Oncology. All rights reserved.
FAU - Chen, Rongrong
AU  - Chen R
AD  - Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai 200030, China.
FAU - Ding, Zhengping
AU  - Ding Z
AD  - Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai 200030, China.
FAU - Zhu, Lei
AU  - Zhu L
AD  - Department of Pathology, Shanghai Chest Hospital, Shanghai Jiao Tong University, 
      Shanghai 200030, China.
FAU - Lu, Shun
AU  - Lu S
AD  - Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai 200030, China. Electronic address: lushun1964@126.com.
FAU - Yu, Yongfeng
AU  - Yu Y
AD  - Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong 
      University, Shanghai 200030, China. Electronic address: yuyongfeng212@126.com.
LA  - eng
PT  - Journal Article
DEP - 20170919
PL  - England
TA  - Eur J Surg Oncol
JT  - European journal of surgical oncology : the journal of the European Society of 
      Surgical Oncology and the British Association of Surgical Oncology
JID - 8504356
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Biomarkers, Tumor/analysis
MH  - Carcinoma, Squamous Cell/*pathology/surgery
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Kaplan-Meier Estimate
MH  - Lung Neoplasms/*pathology/surgery
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Invasiveness
MH  - Neoplasm Staging
MH  - Pneumonectomy
MH  - Prognosis
MH  - Risk Factors
MH  - World Health Organization
OTO - NOTNLM
OT  - Clinicopathologic feature
OT  - Lung squamous cell carcinoma
OT  - Pathological subtype
EDAT- 2017/10/02 06:00
MHDA- 2017/12/12 06:00
CRDT- 2017/10/02 06:00
PHST- 2017/05/08 00:00 [received]
PHST- 2017/08/12 00:00 [revised]
PHST- 2017/09/06 00:00 [accepted]
PHST- 2017/10/02 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
PHST- 2017/10/02 06:00 [entrez]
AID - S0748-7983(17)30701-1 [pii]
AID - 10.1016/j.ejso.2017.09.011 [doi]
PST - ppublish
SO  - Eur J Surg Oncol. 2017 Dec;43(12):2308-2314. doi: 10.1016/j.ejso.2017.09.011. 
      Epub 2017 Sep 19.