PMID- 28965188
OWN - NLM
STAT- MEDLINE
DCOM- 20190207
LR  - 20220408
IS  - 1432-0827 (Electronic)
IS  - 0171-967X (Linking)
VI  - 102
IP  - 1
DP  - 2018 Jan
TI  - Association of Bone Mineral Density, Bone Turnover Markers, and Vertebral 
      Fractures with All-Cause Mortality in Type 2 Diabetes Mellitus.
PG  - 1-13
LID - 10.1007/s00223-017-0324-x [doi]
AB  - Patients with type 2 diabetes mellitus (T2DM) have an increased risk of fragility 
      fracture. However, the association between diabetes-related osteoporosis and 
      mortality in T2DM remains unknown. This historical cohort study assessed the 
      endpoint of all-cause mortality in patients with T2DM. According to our hospital 
      record, bone parameters were examined in 797 patients from 1997 to 2009. We 
      excluded 78 because of diseases affecting bone metabolism and could not follow-up 
      308 patients. Finally, in 411 patients, the associations of bone turnover 
      markers, bone mineral density (BMD), and the prevalence of vertebral fractures 
      with mortality were investigated by Cox regression analyses adjusted for 
      confounding factors. Of 411 patients, 56 died during the follow-up period of 
      almost 7 years. Cox regression analyses showed that reduced BMD at the lumbar 
      spine (LS) and femoral neck (FN) (T-score </= -2.5) and severe vertebral fractures 
      were associated with higher mortality (hazard ratio [HR] 3.25, 95% confidence 
      interval [CI] 1.48-7.16, p = 0.003 for LS-T score </= -2.5; HR 5.19, 95% CI 
      1.83-14.75, p = 0.002 for FN-T score </= -2.5; HR 2.93, 95% CI 1.42-6.02, p = 0.004 
      for multiple vertebral fractures; HR 7.64, 95% CI 2.13-27.42, p = 0.002 for grade 
      3 vertebral fracture). Separate analysis in men and women showed that decreased 
      serum osteocalcin was associated with mortality in women (HR 3.82, 95% CI 
      1.01-14.46 per SD decrease, p = 0.048). The present study is the first to show 
      the association of reduced BMD and severe vertebral fractures with increased 
      all-cause mortality in patients with T2DM. Moreover, higher serum osteocalcin was 
      significantly associated with decreased mortality in women with T2DM.
FAU - Miyake, Hitomi
AU  - Miyake H
AD  - Department of Internal Medicine 1, Faculty of Medicine, Shimane University, 89-1 
      Enya-cho, Izumo, 693-8501, Japan.
FAU - Kanazawa, Ippei
AU  - Kanazawa I
AUID- ORCID: 0000-0001-9001-5609
AD  - Department of Internal Medicine 1, Faculty of Medicine, Shimane University, 89-1 
      Enya-cho, Izumo, 693-8501, Japan. ippei.k@med.shimane-u.ac.jp.
FAU - Sugimoto, Toshitsugu
AU  - Sugimoto T
AD  - Department of Internal Medicine 1, Faculty of Medicine, Shimane University, 89-1 
      Enya-cho, Izumo, 693-8501, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170930
PL  - United States
TA  - Calcif Tissue Int
JT  - Calcified tissue international
JID - 7905481
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Aged
MH  - Bone Density/*physiology
MH  - Diabetes Mellitus, Type 2/complications/*mortality
MH  - Female
MH  - Femur Neck/metabolism
MH  - Humans
MH  - Lumbar Vertebrae/metabolism
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/metabolism
MH  - Osteoporosis/*complications
MH  - Regression Analysis
MH  - Spinal Fractures/complications/*mortality
OTO - NOTNLM
OT  - Bone mineral density
OT  - Mortality
OT  - Osteocalcin
OT  - Osteoporosis
OT  - Type 2 diabetes mellitus
OT  - Vertebral fracture
EDAT- 2017/10/02 06:00
MHDA- 2019/02/08 06:00
CRDT- 2017/10/02 06:00
PHST- 2017/06/29 00:00 [received]
PHST- 2017/09/05 00:00 [accepted]
PHST- 2017/10/02 06:00 [pubmed]
PHST- 2019/02/08 06:00 [medline]
PHST- 2017/10/02 06:00 [entrez]
AID - 10.1007/s00223-017-0324-x [pii]
AID - 10.1007/s00223-017-0324-x [doi]
PST - ppublish
SO  - Calcif Tissue Int. 2018 Jan;102(1):1-13. doi: 10.1007/s00223-017-0324-x. Epub 
      2017 Sep 30.