PMID- 28965341
OWN - NLM
STAT- MEDLINE
DCOM- 20180320
LR  - 20180320
IS  - 1439-3964 (Electronic)
IS  - 0172-4622 (Linking)
VI  - 38
IP  - 13
DP  - 2017 Nov
TI  - Dynamic Expression and the Role of BDNF in Exercise-induced Skeletal Muscle 
      Regeneration.
PG  - 959-966
LID - 10.1055/s-0043-118343 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) is a myokine. However, its role in 
      skeletal muscle has not been well elucidated. In this study, we aimed to 
      investigate its expression profile in skeletal muscle following downhill running 
      and to explore its functions. Male Sprague Dawley rats were assigned to sedentary 
      and downhill running groups. Tail vein blood, total mRNA and protein from soleus 
      muscle was obtained from rats at different time points post-exercise (1d, 3d, 5d, 
      7d and 14d). We found a significant elevation of BDNF mRNA level 5d and 7d 
      post-exercise (p<0.05), increased BDNF protein level 1d, 3d, 7d and 14d 
      post-exercise (p<0.05), and continuously elevated serum BDNF level (p<0.05). In 
      addition, serum creatine kinase activity was increased 5d following exercise 
      (p<0.05); expression of MyoD was elevated (p<0.05); disruption of myofibers and 
      centralized nuclei in damaged myofibers were clearly observed 1d and 5d 
      post-exercise, respectively. Moreover, AMPK phosphorylation was present 1d 
      post-exercise (p<0.05), while AKT was phosphorylated for 5d post-exercise 
      (p<0.05). In conclusion, downhill running induces a time-dependent up-regulation 
      of BDNF in skeletal muscle, which is involved in exercise-induced skeletal muscle 
      regeneration.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Yu, Tao
AU  - Yu T
AD  - China Institute of Sport Science (CISS), Sport Health and Rehabilitation Center, 
      Beijing, China.
FAU - Chang, Yun
AU  - Chang Y
AD  - China Institute of Sport Science (CISS), Sport Health and Rehabilitation Center, 
      Beijing, China.
FAU - Gao, Xiao Lin
AU  - Gao XL
AD  - China Institute of Sport Science (CISS), Sport Health and Rehabilitation Center, 
      Beijing, China.
FAU - Li, Han
AU  - Li H
AD  - China Institute of Sport Science (CISS), Sport Health and Rehabilitation Center, 
      Beijing, China.
FAU - Zhao, Peng
AU  - Zhao P
AD  - China Institute of Sport Science (CISS), Sport Health and Rehabilitation Center, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20171001
PL  - Germany
TA  - Int J Sports Med
JT  - International journal of sports medicine
JID - 8008349
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - EC 2.7.3.2 (Creatine Kinase)
SB  - IM
MH  - AMP-Activated Protein Kinases/metabolism
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Creatine Kinase/blood
MH  - Male
MH  - Muscle, Skeletal/injuries/metabolism/*physiology
MH  - Phosphorylation
MH  - *Physical Conditioning, Animal
MH  - Proto-Oncogene Proteins c-akt/metabolism
MH  - RNA, Messenger/metabolism
MH  - Rats, Sprague-Dawley
MH  - *Regeneration
MH  - Running/*physiology
MH  - Time Factors
MH  - Up-Regulation
COIS- Conflict of interest: We declare that there are no conflicts of interests, 
      whether financial or otherwise.
EDAT- 2017/10/02 06:00
MHDA- 2018/03/21 06:00
CRDT- 2017/10/02 06:00
PHST- 2017/10/02 06:00 [pubmed]
PHST- 2018/03/21 06:00 [medline]
PHST- 2017/10/02 06:00 [entrez]
AID - 10.1055/s-0043-118343 [doi]
PST - ppublish
SO  - Int J Sports Med. 2017 Nov;38(13):959-966. doi: 10.1055/s-0043-118343. Epub 2017 
      Oct 1.