PMID- 28965568
OWN - NLM
STAT- MEDLINE
DCOM- 20180528
LR  - 20221207
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 44
DP  - 2017 Dec
TI  - Association of reduced zinc status with poor glycemic control in individuals with 
      type 2 diabetes mellitus.
PG  - 132-136
LID - S0946-672X(17)30636-3 [pii]
LID - 10.1016/j.jtemb.2017.07.004 [doi]
AB  - This study evaluated the relationship between the zinc-related nutritional status 
      and glycemic and insulinemic markers in individuals with type 2 diabetes mellitus 
      (T2DM). A total of 82 individuals with T2DM aged between 29 and 59 years were 
      evaluated. The concentration of zinc in the plasma, erythrocytes, and urine was 
      determined by the flame atomic absorption spectrometry method. Dietary intake was 
      assessed using a 3-day 24-h recall. In addition, concentrations of serum glucose, 
      glycated hemoglobin percentage, total cholesterol and fractions, triglycerides, 
      and serum insulin were determined. The insulin resistance index (HOMA-IR) and 
      beta-cell function (HOMA- beta) were calculated. The markers of zinc status (plasma: 
      83.3+/-11.9mug/dL, erythrocytes: 30.1+/-4.6mug/g Hb, urine: 899.1+/-622.4mug Zn/24h, and 
      dietary: 9.9+/-0.8mg/day) were classified in tertiles and compared to insulinemic 
      and glycemic markers. The results showed that lower zinc concentrations in plasma 
      and erythrocytes, as well as its high urinary excretion, were associated with 
      higher percentages of glycated hemoglobin, reflecting a worse glycemic control in 
      individuals with T2DM (p<0.05). Furthermore, there was a significant inverse 
      correlation between plasma zinc levels and glycated hemoglobin percentage 
      (r=-0.325, p=0.003), and a positive correlation between urinary zinc excretion 
      and glycemia (r=0.269, p=0.016), glycated hemoglobin percentage (r=0.318, 
      p=0.004) and HOMA-IR (r=0.289, p=0.009). According to our study results, conclude 
      that T2DM individuals with reduced zinc status exhibited poor glycemic control.
CI  - Copyright (c) 2017 Elsevier GmbH. All rights reserved.
FAU - Bandeira, Veronica da Silva
AU  - Bandeira VDS
AD  - Nutrition-Minerals Laboratory, Department of Food and Experimental Nutrition, 
      Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu 
      Prestes, 580-Bloco 14, Butanta, 05508900, SP, Brazil.
FAU - Pires, Liliane Viana
AU  - Pires LV
AD  - Department of Nutrition, Federal University of Sergipe, Avenida Marechal Rondon, 
      S/n - Jardim Rosa Elze, 49100000, Sao Cristovao, Sergipe, Brazil. Electronic 
      address: lvpires@usp.br.
FAU - Hashimoto, Leila Leiko
AU  - Hashimoto LL
AD  - Nutrition-Minerals Laboratory, Department of Food and Experimental Nutrition, 
      Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu 
      Prestes, 580-Bloco 14, Butanta, 05508900, SP, Brazil.
FAU - Alencar, Luciane Luca de
AU  - Alencar LL
AD  - Nutrition-Minerals Laboratory, Department of Food and Experimental Nutrition, 
      Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu 
      Prestes, 580-Bloco 14, Butanta, 05508900, SP, Brazil.
FAU - Almondes, Kaluce Goncalves Sousa
AU  - Almondes KGS
AD  - Nutrition-Minerals Laboratory, Department of Food and Experimental Nutrition, 
      Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu 
      Prestes, 580-Bloco 14, Butanta, 05508900, SP, Brazil.
FAU - Lottenberg, Simao Augusto
AU  - Lottenberg SA
AD  - Clinics Hospital of the Faculty of Medicine of the University of Sao Paulo, 
      Endocrinology and Metabolism Service, Av. Dr. Eneas Carvalho de Aguiar, 255, 
      05403900, Sao Paulo, Brazil.
FAU - Cozzolino, Silvia Maria Franciscato
AU  - Cozzolino SMF
AD  - Nutrition-Minerals Laboratory, Department of Food and Experimental Nutrition, 
      Faculty of Pharmaceutical Sciences, University of Sao Paulo, Av. Prof. Lineu 
      Prestes, 580-Bloco 14, Butanta, 05508900, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20170712
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 0 (Biomarkers)
RN  - 0 (Glycated Hemoglobin A)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Diet
MH  - Erythrocytes/metabolism
MH  - Female
MH  - Glycated Hemoglobin/metabolism
MH  - Humans
MH  - Hyperglycemia/*blood
MH  - Male
MH  - Middle Aged
MH  - Zinc/*blood
OTO - NOTNLM
OT  - Glycated hemoglobin
OT  - Glycemia
OT  - Insulin
OT  - Type 2 diabetes mellitus
OT  - Zinc
EDAT- 2017/10/03 06:00
MHDA- 2018/05/29 06:00
CRDT- 2017/10/03 06:00
PHST- 2017/06/10 00:00 [received]
PHST- 2017/07/01 00:00 [revised]
PHST- 2017/07/10 00:00 [accepted]
PHST- 2017/10/03 06:00 [entrez]
PHST- 2017/10/03 06:00 [pubmed]
PHST- 2018/05/29 06:00 [medline]
AID - S0946-672X(17)30636-3 [pii]
AID - 10.1016/j.jtemb.2017.07.004 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2017 Dec;44:132-136. doi: 10.1016/j.jtemb.2017.07.004. 
      Epub 2017 Jul 12.